hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11805.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LRRC8E | Volume-regulated anion channel subunit LRRC8E (Leucine-rich repeat-containing protein 8E) | 5 | UniProt NCBI |
| LRRC8A | Volume-regulated anion channel subunit LRRC8A (Leucine-rich repeat-containing protein 8A) (HsLRRC8A) (Swelling protein 1) | 5 | UniProt NCBI |
| NPEPPS | Puromycin-sensitive aminopeptidase (PSA) (EC 3.4.11.14) (Cytosol alanyl aminopeptidase) (AAP-S) | 5 | UniProt NCBI |
| LRRC8D | Volume-regulated anion channel subunit LRRC8D (Leucine-rich repeat-containing protein 5) (Leucine-rich repeat-containing protein 8D) (HsLRRC8D) | 5 | UniProt NCBI |
| LRRC8C | Volume-regulated anion channel subunit LRRC8C (Factor for adipocyte differentiation 158) (Leucine-rich repeat-containing protein 8C) | 5 | UniProt NCBI |
| LRRC8B | Volume-regulated anion channel subunit LRRC8B (Leucine-rich repeat-containing protein 8B) (T-cell activation leucine repeat-rich protein) (TA-LRRP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6567 | 1.3145096165e-16 | 0.833333333333 | LRRC8C LRRC8D LRRC8E LRRC8B LRRC8A | SWELL1-containing complex |
| REAC:R-HSA-5223345 | 3.07686692355e-12 | 0.833333333333 | LRRC8C LRRC8D LRRC8E LRRC8B LRRC8A | Miscellaneous transport and binding events |
| GO:0005225 | 6.80576638125e-12 | 0.833333333333 | LRRC8C LRRC8D LRRC8E LRRC8B LRRC8A | volume-sensitive anion channel activity |
| WP:WP5083 | 9.87432706391e-09 | 0.833333333333 | LRRC8C LRRC8D LRRC8E LRRC8B LRRC8A | Neuroinflammation and glutamatergic signaling |
| GO:0098656 | 6.58565753718e-08 | 0.833333333333 | LRRC8C LRRC8D LRRC8E LRRC8B LRRC8A | monoatomic anion transmembrane transport |
| GO:0005253 | 2.05770372523e-07 | 0.833333333333 | LRRC8C LRRC8D LRRC8E LRRC8B LRRC8A | monoatomic anion channel activity |
| GO:0006820 | 8.66872449153e-07 | 0.833333333333 | LRRC8C LRRC8D LRRC8E LRRC8B LRRC8A | monoatomic anion transport |
| GO:0008509 | 1.37824060181e-06 | 0.833333333333 | LRRC8C LRRC8D LRRC8E LRRC8B LRRC8A | monoatomic anion transmembrane transporter activity |
| GO:1903790 | 7.68841921772e-06 | 0.5 | LRRC8C LRRC8E LRRC8A | guanine nucleotide transmembrane transport |
| GO:0140361 | 7.68841921772e-06 | 0.5 | LRRC8C LRRC8E LRRC8A | cyclic-GMP-AMP transmembrane import across plasma membrane |
| CORUM:6582 | 1.70876175213e-05 | 0.333333333333 | LRRC8D LRRC8A | LRRC8A-LRRC8D complex |
| CORUM:6581 | 1.70876175213e-05 | 0.333333333333 | LRRC8A LRRC8C | LRRC8A-LRRC8C complex |
| CORUM:6583 | 1.70876175213e-05 | 0.333333333333 | LRRC8E LRRC8A | LRRC8A-LRRC8E complex |
| GO:0001408 | 1.92180881975e-05 | 0.5 | LRRC8C LRRC8E LRRC8A | guanine nucleotide transport |
| GO:0034702 | 5.45422005277e-05 | 0.833333333333 | LRRC8C LRRC8D LRRC8E LRRC8B LRRC8A | monoatomic ion channel complex |
| GO:0070729 | 6.72425931667e-05 | 0.5 | LRRC8C LRRC8E LRRC8A | cyclic nucleotide transport |
| REAC:R-HSA-382551 | 6.77703888853e-05 | 0.833333333333 | LRRC8C LRRC8D LRRC8E LRRC8B LRRC8A | Transport of small molecules |
| GO:0034214 | 0.000161332517231 | 0.5 | LRRC8D LRRC8A LRRC8C | protein hexamerization |
| GO:1902495 | 0.000368555564933 | 0.833333333333 | LRRC8C LRRC8D LRRC8E LRRC8B LRRC8A | transmembrane transporter complex |
| GO:0005216 | 0.000537225298565 | 0.833333333333 | LRRC8C LRRC8D LRRC8E LRRC8B LRRC8A | monoatomic ion channel activity |
| GO:1990351 | 0.000547564742709 | 0.833333333333 | LRRC8C LRRC8D LRRC8E LRRC8B LRRC8A | transporter complex |
| GO:0015267 | 0.000908281040922 | 0.833333333333 | LRRC8C LRRC8D LRRC8E LRRC8B LRRC8A | channel activity |
| GO:0022803 | 0.000923996225357 | 0.833333333333 | LRRC8C LRRC8D LRRC8E LRRC8B LRRC8A | passive transmembrane transporter activity |
| GO:1901679 | 0.00185822071527 | 0.5 | LRRC8C LRRC8E LRRC8A | nucleotide transmembrane transport |
| GO:0072530 | 0.00218580514948 | 0.5 | LRRC8C LRRC8E LRRC8A | purine-containing compound transmembrane transport |
| GO:0015868 | 0.00254971303757 | 0.5 | LRRC8C LRRC8E LRRC8A | purine ribonucleotide transport |
| GO:0051503 | 0.00339409783315 | 0.5 | LRRC8C LRRC8E LRRC8A | adenine nucleotide transport |
| GO:0015865 | 0.00387837112504 | 0.5 | LRRC8C LRRC8E LRRC8A | purine nucleotide transport |
| GO:0015075 | 0.00715811587239 | 0.833333333333 | LRRC8C LRRC8D LRRC8E LRRC8B LRRC8A | monoatomic ion transmembrane transporter activity |
| GO:0006862 | 0.00777254411354 | 0.5 | LRRC8C LRRC8E LRRC8A | nucleotide transport |
| GO:0034220 | 0.0102647533522 | 0.833333333333 | LRRC8C LRRC8D LRRC8E LRRC8B LRRC8A | monoatomic ion transmembrane transport |
| GO:0006970 | 0.0219369042126 | 0.5 | LRRC8D LRRC8E LRRC8A | response to osmotic stress |
| GO:1901264 | 0.0271028431288 | 0.5 | LRRC8C LRRC8E LRRC8A | carbohydrate derivative transport |
| GO:0015711 | 0.0327652199679 | 0.666666666667 | LRRC8C LRRC8D LRRC8E LRRC8A | organic anion transport |
| GO:0006811 | 0.0394764540724 | 0.833333333333 | LRRC8C LRRC8D LRRC8E LRRC8B LRRC8A | monoatomic ion transport |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NPEPPS | LRRC8E | 0.999 | 0.12 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| LRRC8A | LRRC8B | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LRRC8B | LRRC8E | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LRRC8C | LRRC8B | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LRRC8D | LRRC8B | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NPEPPS | LRRC8B | 0.983 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NPEPPS | LRRC8A | 0.98 | 0.06 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| LRRC8A | LRRC8E | 0.95 | 0.088 | bioplex_WMM bioplex3_WMM WMM_only |
| NPEPPS | LRRC8D | 0.946 | 0.116 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| NPEPPS | LRRC8C | 0.855 | 0.03 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| LRRC8C | LRRC8E | 0.848 | 0.06 | bioplex_WMM bioplex3_WMM WMM_only |
| LRRC8A | LRRC8C | 0.609 | 0.118 | bioplex_WMM bioplex3_WMM WMM_only |
| LRRC8D | LRRC8E | 0.408 | 0.138 | bioplex_WMM bioplex3_WMM WMM_only |
| LRRC8D | LRRC8C | 0.396 | 0.05 | bioplex_WMM bioplex3_WMM WMM_only |
| LRRC8D | LRRC8A | 0.353 | 0.082 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes