hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11806.1
Complex Portal: CPX-16759
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CYP2B6 | Cytochrome P450 2B6 (EC 1.14.13.-) (1,4-cineole 2-exo-monooxygenase) (CYPIIB6) (Cytochrome P450 IIB1) | 5 | UniProt NCBI |
| PGRMC1 | Membrane-associated progesterone receptor component 1 (mPR) (Dap1) (IZA) | 5 | UniProt NCBI |
| CYP2U1 | Cytochrome P450 2U1 (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80) | 5 | UniProt NCBI |
| PTPRCAP | Protein tyrosine phosphatase receptor type C-associated protein (PTPRC-associated protein) (CD45-associated protein) (CD45-AP) (Lymphocyte phosphatase-associated phosphoprotein) | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP43 | 0.002190823719 | 0.5 | CYP2B6 CYP2U1 | Oxidation by cytochrome P450 |
| KEGG:00590 | 0.00281740883519 | 0.5 | CYP2B6 CYP2U1 | Arachidonic acid metabolism |
| REAC:R-HSA-211897 | 0.0101102645678 | 0.5 | CYP2B6 CYP2U1 | Cytochrome P450 - arranged by substrate type |
| GO:0020037 | 0.0218982649712 | 0.75 | CYP2U1 CYP2B6 PGRMC1 | heme binding |
| WP:WP702 | 0.0228199530946 | 0.5 | CYP2B6 CYP2U1 | Metapathway biotransformation Phase I and II |
| GO:0046906 | 0.0280178993418 | 0.75 | CYP2U1 CYP2B6 PGRMC1 | tetrapyrrole binding |
| REAC:R-HSA-211945 | 0.0297941212351 | 0.5 | CYP2B6 CYP2U1 | Phase I - Functionalization of compounds |
| WP:WP1600 | 0.0373138951921 | 0.25 | CYP2B6 | Nicotine metabolism in liver cells |
| WP:WP2491 | 0.049746753544 | 0.25 | CYP2B6 | Diclofenac metabolic pathway |
| CORUM:1990 | 0.049938562206 | 0.25 | PGRMC1 | PGRMC1-SCAP complex |
| REAC:R-HSA-5579011 | 0.0499436884912 | 0.25 | CYP2U1 | Defective CYP2U1 causes SPG56 |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CYP2B6 | PGRMC1 | 0.958 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| PGRMC1 | PTPRCAP | 0.939 | 0.034 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PGRMC1 | CYP2U1 | 0.892 | 0.16 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| CYP2B6 | huMAP3_02035.1 huMAP3_11806.1 huMAP3_12646.1 huMAP3_14673.1 |
| PGRMC1 | huMAP3_02035.1 huMAP3_11806.1 |
| CYP2U1 | huMAP3_11806.1 |
| PTPRCAP | huMAP3_04995.1 huMAP3_05434.1 huMAP3_06458.1 huMAP3_08929.1 huMAP3_10587.1 huMAP3_11072.1 huMAP3_11806.1 huMAP3_13564.1 huMAP3_14712.1 |