hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_11807.1

Complex Portal: CPX-16287

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
RAB5IF	GEL complex subunit OPTI (Obligate partner of TMCO1 insertase) (Rab5-interacting protein) (RIP5) (Respirasome Complex Assembly Factor 1)	5	UniProt NCBI
SLC25A28	Mitoferrin-2 (Mitochondrial RNA-splicing protein 3/4 homolog) (MRS3/4) (hMRS3/4) (Mitochondrial iron transporter 2) (Solute carrier family 25 member 28)	4	UniProt NCBI
ORMDL1	ORM1-like protein 1 (Adoplin-1)	5	UniProt NCBI
ORMDL3	ORM1-like protein 3	5	UniProt NCBI
HACD1	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 1) (HACD1) (Cementum-attachment protein) (CAP) (Protein-tyrosine phosphatase-like member A)	5	UniProt NCBI
HTR2C	5-hydroxytryptamine receptor 2C (5-HT-2C) (5-HT2C) (5-HTR2C) (5-hydroxytryptamine receptor 1C) (5-HT-1C) (5-HT1C) (Serotonin receptor 2C)	5	UniProt NCBI
SLC18A2	Synaptic vesicular amine transporter (Monoamine transporter) (Solute carrier family 18 member 2) (Vesicular amine transporter 2) (VAT2)	5	UniProt NCBI
PAQR5	Membrane progestin receptor gamma (mPR gamma) (Membrane progesterone P4 receptor gamma) (Membrane progesterone receptor gamma) (Progesterone and adipoQ receptor family member 5) (Progestin and adipoQ receptor family member 5) (Progestin and adipoQ receptor family member V)	4	UniProt NCBI
GPR50	Melatonin-related receptor (G protein-coupled receptor 50) (H9) [Cleaved into: C-terminal domain]	5	UniProt NCBI
ABCC3	ATP-binding cassette sub-family C member 3 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multispecific organic anion transporter 2) (Multi-specific organic anion transporter D) (MOAT-D) (Multidrug resistance-associated protein 3)	5	UniProt NCBI
PIGW	Phosphatidylinositol-glycan biosynthesis class W protein (PIG-W) (EC 2.3.-.-)	5	UniProt NCBI
SLC2A12	Solute carrier family 2, facilitated glucose transporter member 12 (Glucose transporter type 12) (GLUT-12)	4	UniProt NCBI
TMEM115	Transmembrane protein 115 (Placental protein 6) (Protein PL6)	5	UniProt NCBI
SLC49A4	Solute carrier family 49 member 4 (Disrupted in renal cancer protein 2) (Disrupted in renal carcinoma protein 2)	5	UniProt NCBI
CLDN7	Claudin-7 (CLDN-7)	5	UniProt NCBI
EIF2D	Eukaryotic translation initiation factor 2D (eIF2d) (Hepatocellular carcinoma-associated antigen 56) (Ligatin)	5	UniProt NCBI
SLC22A4	Solute carrier family 22 member 4 (Ergothioneine transporter) (ET transporter) (ETTh) (Organic cation/carnitine transporter 1) (OCTN1)	5	UniProt NCBI
SLC35G2	Solute carrier family 35 member G2 (Transmembrane protein 22)	5	UniProt NCBI
AQP3	Aquaporin-3 (AQP-3) (Aquaglyceroporin-3)	5	UniProt NCBI
SLC22A9	Organic anion transporter 7 (OAT7) (Organic anion/short-chain fatty acid exchanger) (Solute carrier family 22 member 9)	5	UniProt NCBI
TMEM242	Transmembrane protein 242	5	UniProt NCBI
SLC22A5	Organic cation/carnitine transporter 2 (High-affinity sodium-dependent carnitine cotransporter) (Solute carrier family 22 member 5)	5	UniProt NCBI
GPR12	G-protein coupled receptor 12	4	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0016020	0.01336781632	0.913043478261	GPR12 SLC2A12 RAB5IF SLC25A28 AQP3 ORMDL3 SLC22A9 TMEM115 SLC49A4 TMEM242 GPR50 SLC35G2 CLDN7 HACD1 PIGW ABCC3 SLC18A2 ORMDL1 SLC22A5 SLC22A4 HTR2C	membrane
REAC:R-HSA-549127	0.021275594584	0.0869565217391	SLC22A4 SLC22A5	Organic cation transport
REAC:R-HSA-425366	0.0244401547161	0.130434782609	SLC22A5 SLC18A2 SLC22A4	Transport of bile salts and organic acids, metal ions and amine compounds
REAC:R-HSA-425407	0.0335966479291	0.173913043478	SLC2A12 SLC22A5 SLC18A2 SLC22A4	SLC-mediated transmembrane transport
REAC:R-HSA-549132	0.0416714044752	0.0869565217391	SLC22A4 SLC22A5	Organic cation/anion/zwitterion transport
REAC:R-HSA-382551	0.043830343121	0.260869565217	SLC2A12 SLC22A4 ABCC3 SLC22A5 AQP3 SLC18A2	Transport of small molecules

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
SLC22A9	CLDN7	0.998
PAQR5	SLC22A9	0.997
SLC22A9	TMEM242	0.994
SLC22A9	TMEM115	0.992
SLC22A9	ORMDL1	0.989
SLC22A9	ORMDL3	0.988
HACD1	GPR12	0.987
SLC49A4	SLC22A4	0.987
HACD1	SLC22A4	0.987		structurally_consistent (dimer)
SLC22A4	ABCC3	0.985
TMEM242	GPR12	0.984
SLC2A12	TMEM242	0.984
SLC22A9	SLC22A5	0.983
AQP3	ORMDL3	0.982
SLC22A4	TMEM115	0.982
SLC25A28	SLC2A12	0.982
HTR2C	SLC35G2	0.98
SLC35G2	GPR12	0.98		structurally_consistent (dimer)
ORMDL3	SLC2A12	0.98
AQP3	TMEM242	0.98
AQP3	ORMDL1	0.978
SLC18A2	ORMDL1	0.969
SLC22A9	RAB5IF	0.962
SLC25A28	GPR12	0.961		structurally_consistent (dimer)
ORMDL1	RAB5IF	0.955	0.076
SLC22A4	SLC22A5	0.948		structurally_consistent (dimer)
SLC22A4	ORMDL1	0.942
PIGW	SLC2A12	0.942
SLC22A4	RAB5IF	0.939
SLC22A4	ORMDL3	0.938
GPR50	HTR2C	0.934
SLC22A4	TMEM242	0.934
SLC22A4	SLC35G2	0.923
SLC22A9	PIGW	0.916
SLC22A4	EIF2D	0.915
SLC2A12	GPR12	0.909
PAQR5	CLDN7	0.902
GPR50	GPR12	0.872		structurally_consistent (dimer)
SLC22A5	GPR12	0.869
SLC22A4	PIGW	0.818
ORMDL1	GPR12	0.817		structurally_consistent (dimer)
SLC22A4	GPR50	0.806
SLC18A2	ORMDL3	0.804
AQP3	PIGW	0.701
HACD1	SLC35G2	0.527	0.09
TMEM115	ORMDL1	0.497	0.1
ORMDL3	TMEM115	0.492	0.156
SLC22A5	TMEM242	0.428
ABCC3	EIF2D	0.415	0.03
SLC49A4	EIF2D	0.415	0.026
SLC49A4	ABCC3	0.415	0.056
GPR50	SLC35G2	0.396
PIGW	TMEM115	0.37
SLC22A5	RAB5IF	0.37
PIGW	TMEM242	0.342
ORMDL3	TMEM242	0.328	0.098
TMEM242	ORMDL1	0.304	0.126
ORMDL3	ORMDL1	0.301	0.214
SLC25A28	TMEM242	0.3	0.156
SLC25A28	ORMDL3	0.279	0.124
HACD1	EIF2D	0.278	0.054
TMEM115	EIF2D	0.274	0.03
TMEM242	TMEM115	0.262	0.146
SLC22A5	ORMDL1	0.262
SLC25A28	HACD1	0.262	0.096
SLC49A4	HACD1	0.25	0.148
HACD1	ABCC3	0.25	0.054
SLC35G2	ORMDL1	0.246	0.074	structurally_consistent (P47775)
SLC25A28	SLC35G2	0.218	0.062
TMEM115	RAB5IF	0.218	0.1
PIGW	SLC22A5	0.202
SLC25A28	RAB5IF	0.187	0.112
SLC25A28	PIGW	0.165
ORMDL3	RAB5IF	0.165	0.162
ORMDL3	SLC22A5	0.165
TMEM242	RAB5IF	0.165	0.1
PIGW	RAB5IF	0.159
PIGW	SLC35G2	0.159
PAQR5	TMEM115	0.146
GPR50	PIGW	0.128
HACD1	SLC2A12	0.113
SLC22A5	EIF2D	0.113
ABCC3	TMEM115	0.113	0.048
SLC22A5	TMEM115	0.113
PIGW	ORMDL3	0.108
GPR50	SLC2A12	0.105
GPR50	EIF2D	0.102
HACD1	PIGW	0.102
ABCC3	GPR50	0.097
SLC49A4	GPR50	0.097
SLC35G2	RAB5IF	0.097	0.052
TMEM242	EIF2D	0.095	0.144
HACD1	TMEM115	0.095	0.074
EIF2D	RAB5IF	0.095	0.05
SLC35G2	EIF2D	0.095	0.044
SLC25A28	ORMDL1	0.095	0.13	structurally_consistent (P47775)
HACD1	ORMDL3	0.089	0.07
GPR50	TMEM115	0.082
ORMDL3	SLC35G2	0.081	0.094
TMEM242	SLC35G2	0.081	0.07
HACD1	GPR50	0.081
SLC22A5	SLC35G2	0.081
HACD1	ORMDL1	0.079	0.184
SLC49A4	TMEM115	0.079	0.148
SLC49A4	ORMDL3	0.079	0.1
ABCC3	ORMDL1	0.079	0.034
HACD1	TMEM242	0.079	0.116
HACD1	SLC22A5	0.079
ABCC3	ORMDL3	0.079	0.058
ABCC3	PIGW	0.079
SLC49A4	TMEM242	0.078	0.098
ORMDL3	EIF2D	0.078	0.004
SLC49A4	SLC35G2	0.078	0.06
ORMDL1	EIF2D	0.078	0.016
SLC49A4	SLC22A5	0.078
ABCC3	SLC22A5	0.078
ABCC3	SLC35G2	0.078	0.048
ABCC3	TMEM242	0.078	0.046
PIGW	EIF2D	0.078
ABCC3	RAB5IF	0.078	0.038
SLC49A4	RAB5IF	0.078	0.094
SLC49A4	ORMDL1	0.076	0.086
SLC2A12	SLC35G2	0.076
SLC2A12	ORMDL1	0.076
SLC25A28	SLC22A5	0.076
HACD1	RAB5IF	0.076	0.064
SLC2A12	SLC22A5	0.076
SLC49A4	PIGW	0.076
SLC35G2	TMEM115	0.076	0.096
PIGW	ORMDL1	0.07
GPR50	ORMDL1	0.069		structurally_consistent (P47775)
PAQR5	SLC22A5	0.055
CLDN7	TMEM115	0.055
GPR50	SLC22A5	0.055
GPR50	TMEM242	0.055
SLC25A28	GPR50	0.049
PIGW	CLDN7	0.046
PAQR5	TMEM242	0.046
PAQR5	RAB5IF	0.046
GPR50	RAB5IF	0.044
PAQR5	PIGW	0.043
CLDN7	TMEM242	0.043
CLDN7	SLC22A5	0.043
PAQR5	ORMDL1	0.043
PAQR5	ORMDL3	0.043
CLDN7	RAB5IF	0.043
ORMDL3	CLDN7	0.042
CLDN7	ORMDL1	0.042
GPR50	ORMDL3	0.03

Related Complexes

Genename	Complexes
RAB5IF	huMAP3_11807.1 huMAP3_14030.1 huMAP3_14859.1
SLC25A28	huMAP3_00176.1 huMAP3_03108.1 huMAP3_05571.1 huMAP3_09967.1 huMAP3_10343.1 huMAP3_11807.1 huMAP3_13137.1 huMAP3_13219.1 huMAP3_13912.1 huMAP3_14789.1
ORMDL1	huMAP3_09133.1 huMAP3_11807.1 huMAP3_13429.1 huMAP3_14251.1 huMAP3_14431.1 huMAP3_14859.1
ORMDL3	huMAP3_02581.1 huMAP3_08192.1 huMAP3_08330.1 huMAP3_09129.1 huMAP3_09260.1 huMAP3_09967.1 huMAP3_10343.1 huMAP3_11807.1 huMAP3_12795.1 huMAP3_15312.1
HACD1	huMAP3_00508.1 huMAP3_00944.1 huMAP3_07802.1 huMAP3_10749.1 huMAP3_11807.1 huMAP3_13137.1 huMAP3_14789.1
HTR2C	huMAP3_04358.1 huMAP3_09388.1 huMAP3_11807.1 huMAP3_14613.1
SLC18A2	huMAP3_01003.1 huMAP3_06515.1 huMAP3_06575.1 huMAP3_06966.1 huMAP3_11807.1 huMAP3_11933.1 huMAP3_14859.1 huMAP3_15047.1
PAQR5	huMAP3_01077.1 huMAP3_07511.1 huMAP3_08190.1 huMAP3_10532.1 huMAP3_11348.1 huMAP3_11807.1 huMAP3_12833.1 huMAP3_12842.1 huMAP3_14143.1
GPR50	huMAP3_01430.1 huMAP3_02546.1 huMAP3_05214.1 huMAP3_06539.1 huMAP3_08260.1 huMAP3_09364.1 huMAP3_11136.1 huMAP3_11807.1 huMAP3_12321.1
ABCC3	huMAP3_00672.1 huMAP3_11807.1 huMAP3_14859.1
PIGW	huMAP3_01752.1 huMAP3_03783.1 huMAP3_04203.1 huMAP3_06205.1 huMAP3_06493.1 huMAP3_07406.1 huMAP3_08014.1 huMAP3_08118.1 huMAP3_08419.1 huMAP3_10274.1 huMAP3_11383.1 huMAP3_11807.1
SLC2A12	huMAP3_03108.1 huMAP3_08192.1 huMAP3_09129.1 huMAP3_09260.1 huMAP3_09967.1 huMAP3_10343.1 huMAP3_11807.1
TMEM115	huMAP3_06028.1 huMAP3_08190.1 huMAP3_11807.1 huMAP3_13988.1 huMAP3_14859.1
SLC49A4	huMAP3_00508.1 huMAP3_06893.1 huMAP3_11383.1 huMAP3_11807.1 huMAP3_12493.1 huMAP3_12885.1 huMAP3_14859.1
CLDN7	huMAP3_03122.1 huMAP3_08620.1 huMAP3_09171.1 huMAP3_11348.1 huMAP3_11807.1 huMAP3_12833.1 huMAP3_12842.1 huMAP3_14143.1
EIF2D	huMAP3_11383.1 huMAP3_11807.1 huMAP3_12493.1 huMAP3_12778.1 huMAP3_12885.1 huMAP3_14859.1
SLC22A4	huMAP3_00508.1 huMAP3_06893.1 huMAP3_11383.1 huMAP3_11807.1 huMAP3_12493.1 huMAP3_12885.1 huMAP3_14859.1
SLC35G2	huMAP3_04365.1 huMAP3_07802.1 huMAP3_11807.1
AQP3	huMAP3_00656.1 huMAP3_04573.1 huMAP3_11807.1 huMAP3_12049.1 huMAP3_12846.1 huMAP3_13925.1 huMAP3_15167.1
SLC22A9	huMAP3_01077.1 huMAP3_07511.1 huMAP3_08190.1 huMAP3_10532.1 huMAP3_11807.1 huMAP3_14859.1
TMEM242	huMAP3_04108.1 huMAP3_06631.1 huMAP3_11807.1 huMAP3_14629.1
SLC22A5	huMAP3_03783.1 huMAP3_06951.1 huMAP3_08419.1 huMAP3_10274.1 huMAP3_11383.1 huMAP3_11807.1 huMAP3_14859.1
GPR12	huMAP3_11807.1 huMAP3_13137.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_11807.1

Complex Portal: CPX-16287