hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11825.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ERCC4 | DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein) | 5 | UniProt NCBI |
| ERCC1 | DNA excision repair protein ERCC-1 | 5 | UniProt NCBI |
| XPA | DNA repair protein complementing XP-A cells (Xeroderma pigmentosum group A-complementing protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:531 | 2.33868713081e-10 | 1.0 | XPA ERCC4 ERCC1 | XPA-ERCC1-ERCC4 complex |
| GO:0000110 | 9.61200410764e-08 | 1.0 | XPA ERCC4 ERCC1 | nucleotide-excision repair factor 1 complex |
| WP:WP4753 | 9.56626957197e-07 | 1.0 | XPA ERCC4 ERCC1 | Nucleotide excision repair |
| KEGG:03420 | 1.61189129753e-06 | 1.0 | XPA ERCC4 ERCC1 | Nucleotide excision repair |
| CORUM:2220 | 3.41752350426e-06 | 0.666666666667 | ERCC4 ERCC1 | RAD52-ERCC4-ERCC1 complex |
| WP:WP5114 | 4.82119522161e-06 | 1.0 | XPA ERCC4 ERCC1 | Nucleotide excision repair in xeroderma pigmentosum |
| REAC:R-HSA-5696400 | 4.97397882464e-06 | 1.0 | XPA ERCC4 ERCC1 | Dual Incision in GG-NER |
| REAC:R-HSA-5696395 | 5.35659258038e-06 | 1.0 | XPA ERCC4 ERCC1 | Formation of Incision Complex in GG-NER |
| CORUM:7295 | 1.02521027753e-05 | 0.666666666667 | ERCC1 XPA | ERCC1-RPA1-XPA complex |
| CORUM:368 | 1.02521027753e-05 | 0.666666666667 | ERCC4 ERCC1 | ERCC1-ERCC4-MSH2 complex |
| GO:0000109 | 1.58598067776e-05 | 1.0 | XPA ERCC4 ERCC1 | nucleotide-excision repair complex |
| WP:WP4946 | 1.81493241431e-05 | 1.0 | XPA ERCC4 ERCC1 | DNA repair pathways full network |
| REAC:R-HSA-6782135 | 1.94405116088e-05 | 1.0 | XPA ERCC4 ERCC1 | Dual incision in TC-NER |
| REAC:R-HSA-6781827 | 3.4131946625e-05 | 1.0 | XPA ERCC4 ERCC1 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| REAC:R-HSA-5696399 | 4.28718713308e-05 | 1.0 | XPA ERCC4 ERCC1 | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-5696398 | 9.52596267282e-05 | 1.0 | XPA ERCC4 ERCC1 | Nucleotide Excision Repair |
| HP:0000509 | 0.000101731373204 | 1.0 | XPA ERCC4 ERCC1 | Conjunctivitis |
| HP:0000992 | 0.000112370389643 | 1.0 | XPA ERCC4 ERCC1 | Cutaneous photosensitivity |
| HP:0025337 | 0.000116074907982 | 1.0 | XPA ERCC4 ERCC1 | Red eye |
| HP:0006313 | 0.000189776464884 | 0.666666666667 | ERCC4 ERCC1 | Widely spaced primary teeth |
| HP:0006334 | 0.000265674927589 | 0.666666666667 | ERCC4 ERCC1 | Hypoplasia of the primary teeth |
| HP:0010649 | 0.000354217072454 | 0.666666666667 | ERCC4 XPA | Flat nasal alae |
| HP:0000502 | 0.000396005909772 | 1.0 | XPA ERCC4 ERCC1 | Abnormal conjunctiva morphology |
| HP:0001034 | 0.000734362309502 | 1.0 | XPA ERCC4 ERCC1 | Hypermelanotic macule |
| HP:0100533 | 0.000773463249455 | 1.0 | XPA ERCC4 ERCC1 | Inflammatory abnormality of the eye |
| KEGG:03460 | 0.000895799081076 | 0.666666666667 | ERCC4 ERCC1 | Fanconi anemia pathway |
| HP:0007400 | 0.00113733389144 | 1.0 | XPA ERCC4 ERCC1 | Irregular hyperpigmentation |
| HP:0009755 | 0.00115089028102 | 0.666666666667 | ERCC4 XPA | Ankyloblepharon |
| HP:0012733 | 0.00118955132024 | 1.0 | XPA ERCC4 ERCC1 | Macule |
| HP:0000674 | 0.00132788970801 | 0.666666666667 | ERCC4 ERCC1 | Anodontia |
| HP:0003079 | 0.00132788970801 | 0.666666666667 | ERCC4 XPA | Defective DNA repair after ultraviolet radiation damage |
| GO:1901255 | 0.00140460216025 | 0.666666666667 | ERCC4 XPA | nucleotide-excision repair involved in interstrand cross-link repair |
| GO:1905764 | 0.00140460216025 | 0.666666666667 | ERCC4 ERCC1 | regulation of protection from non-homologous end joining at telomere |
| GO:0061819 | 0.00140460216025 | 0.666666666667 | ERCC4 ERCC1 | telomeric DNA-containing double minutes formation |
| GO:1905765 | 0.00140460216025 | 0.666666666667 | ERCC4 ERCC1 | negative regulation of protection from non-homologous end joining at telomere |
| GO:1990599 | 0.00140460216025 | 0.666666666667 | ERCC4 ERCC1 | 3' overhang single-stranded DNA endodeoxyribonuclease activity |
| HP:0000680 | 0.00151751896202 | 0.666666666667 | ERCC4 ERCC1 | Delayed eruption of primary teeth |
| HP:0000613 | 0.00162209063914 | 1.0 | XPA ERCC4 ERCC1 | Photophobia |
| HP:0006739 | 0.00171977631115 | 0.666666666667 | ERCC4 XPA | Squamous cell carcinoma of the skin |
| KEGG:01524 | 0.00183782119288 | 0.666666666667 | ERCC1 XPA | Platinum drug resistance |
| HP:0003254 | 0.00216216836724 | 0.666666666667 | ERCC4 XPA | Abnormality of DNA repair |
| REAC:R-HSA-73894 | 0.00220643087689 | 1.0 | XPA ERCC4 ERCC1 | DNA Repair |
| HP:0000621 | 0.0024022996104 | 0.666666666667 | ERCC4 XPA | Entropion |
| HP:0000524 | 0.0024022996104 | 0.666666666667 | ERCC4 XPA | Conjunctival telangiectasia |
| HP:5200058 | 0.00244981062097 | 1.0 | XPA ERCC4 ERCC1 | Sensory hypersensitivity |
| GO:0003684 | 0.00252170927764 | 1.0 | XPA ERCC4 ERCC1 | damaged DNA binding |
| HP:0001029 | 0.00265505202111 | 0.666666666667 | ERCC4 XPA | Poikiloderma |
| HP:0000953 | 0.00271630473377 | 1.0 | XPA ERCC4 ERCC1 | Hyperpigmentation of the skin |
| HP:5200046 | 0.0028092510816 | 1.0 | XPA ERCC4 ERCC1 | Sensory behavioral abnormality |
| HP:0004493 | 0.00292042386749 | 0.666666666667 | ERCC4 XPA | Craniofacial hyperostosis |
| HP:0008054 | 0.00348901893966 | 0.666666666667 | ERCC4 XPA | Abnormal morphology of the conjunctival vasculature |
| REAC:R-HSA-5685938 | 0.00405087414568 | 0.666666666667 | ERCC4 ERCC1 | HDR through Single Strand Annealing (SSA) |
| REAC:R-HSA-6783310 | 0.00405087414568 | 0.666666666667 | ERCC4 ERCC1 | Fanconi Anemia Pathway |
| HP:0002120 | 0.0040546723922 | 1.0 | XPA ERCC4 ERCC1 | Cerebral cortical atrophy |
| GO:1904506 | 0.00421361424067 | 0.666666666667 | ERCC4 ERCC1 | negative regulation of telomere maintenance in response to DNA damage |
| GO:0070522 | 0.00421361424067 | 0.666666666667 | ERCC4 ERCC1 | ERCC4-ERCC1 complex |
| HP:0005328 | 0.0047775661087 | 0.666666666667 | ERCC4 ERCC1 | Progeroid facial appearance |
| HP:0008047 | 0.00481840327101 | 1.0 | XPA ERCC4 ERCC1 | Abnormality of the vasculature of the eye |
| HP:0000026 | 0.00626783027637 | 0.666666666667 | ERCC4 ERCC1 | Male hypogonadism |
| HP:0000135 | 0.00645685942958 | 1.0 | XPA ERCC4 ERCC1 | Hypogonadism |
| GO:0034644 | 0.00649050577369 | 1.0 | XPA ERCC4 ERCC1 | cellular response to UV |
| GO:0006289 | 0.00731242824493 | 1.0 | XPA ERCC4 ERCC1 | nucleotide-excision repair |
| HP:0006887 | 0.0075178385046 | 0.666666666667 | ERCC4 XPA | Intellectual disability, progressive |
| HP:0001059 | 0.00795970060154 | 0.666666666667 | ERCC4 XPA | Pterygium |
| HP:0100579 | 0.00841415615575 | 0.666666666667 | ERCC4 XPA | Mucosal telangiectasiae |
| HP:0004437 | 0.00936084070842 | 0.666666666667 | ERCC4 XPA | Cranial hyperostosis |
| HP:0000554 | 0.00936084070842 | 0.666666666667 | ERCC4 ERCC1 | Uveitis |
| HP:0009830 | 0.0100198821414 | 1.0 | XPA ERCC4 ERCC1 | Peripheral neuropathy |
| HP:0001480 | 0.0103578783075 | 0.666666666667 | ERCC4 XPA | Freckling |
| HP:0001000 | 0.0107692028076 | 1.0 | XPA ERCC4 ERCC1 | Abnormality of skin pigmentation |
| GO:0071482 | 0.0112921824257 | 1.0 | XPA ERCC4 ERCC1 | cellular response to light stimulus |
| HP:0100012 | 0.0114052550978 | 0.666666666667 | ERCC4 XPA | Neoplasm of the eye |
| HP:0100774 | 0.0119478163599 | 0.666666666667 | ERCC4 XPA | Hyperostosis |
| HP:0012740 | 0.0119478163599 | 0.666666666667 | ERCC4 XPA | Papilloma |
| HP:0000498 | 0.0130706759587 | 0.666666666667 | ERCC4 XPA | Blepharitis |
| HP:0002353 | 0.0136846015886 | 1.0 | XPA ERCC4 ERCC1 | EEG abnormality |
| HP:0030178 | 0.0164650512957 | 1.0 | XPA ERCC4 ERCC1 | Abnormality of central nervous system electrophysiology |
| HP:0001315 | 0.0185871220188 | 1.0 | XPA ERCC4 ERCC1 | Reduced tendon reflexes |
| HP:0000331 | 0.0194392651505 | 0.666666666667 | ERCC4 ERCC1 | Short chin |
| HP:0000648 | 0.0204103893061 | 1.0 | XPA ERCC4 ERCC1 | Optic atrophy |
| HP:0000995 | 0.0208637442425 | 0.666666666667 | ERCC4 XPA | Melanocytic nevus |
| HP:0000656 | 0.0215948176879 | 0.666666666667 | ERCC4 XPA | Ectropion |
| HP:0008373 | 0.0219766740349 | 1.0 | XPA ERCC4 ERCC1 | Puberty and gonadal disorders |
| HP:0002860 | 0.022338444757 | 0.666666666667 | ERCC4 XPA | Squamous cell carcinoma |
| HP:0000528 | 0.024644630388 | 0.666666666667 | ERCC4 ERCC1 | Anophthalmia |
| GO:0009411 | 0.0263194935275 | 1.0 | XPA ERCC4 ERCC1 | response to UV |
| HP:0001311 | 0.0267277837517 | 1.0 | XPA ERCC4 ERCC1 | Abnormal nervous system electrophysiology |
| HP:0002861 | 0.0287391839378 | 0.666666666667 | ERCC4 XPA | Melanoma |
| GO:1904354 | 0.0294899169624 | 0.666666666667 | ERCC4 ERCC1 | negative regulation of telomere capping |
| GO:0031848 | 0.0294899169624 | 0.666666666667 | ERCC4 ERCC1 | protection from non-homologous end joining at telomere |
| HP:0002059 | 0.0297920863315 | 1.0 | XPA ERCC4 ERCC1 | Cerebral atrophy |
| HP:0100585 | 0.0304647837379 | 0.666666666667 | ERCC4 XPA | Telangiectasia of the skin |
| HPA:0380513 | 0.030835510288 | 1.0 | XPA ERCC4 ERCC1 | placenta; decidual cells[High] |
| HP:0006481 | 0.0322405218297 | 0.666666666667 | ERCC4 ERCC1 | Abnormality of primary teeth |
| HP:0007369 | 0.0329201788467 | 1.0 | XPA ERCC4 ERCC1 | Atrophy/Degeneration affecting the cerebrum |
| HP:0007759 | 0.0331471884053 | 0.666666666667 | ERCC4 XPA | Opacification of the corneal stroma |
| HP:0002172 | 0.0340663843581 | 0.666666666667 | ERCC4 ERCC1 | Postural instability |
| HP:0000491 | 0.0340663843581 | 0.666666666667 | ERCC4 XPA | Keratitis |
| GO:0071478 | 0.0351938724399 | 1.0 | XPA ERCC4 ERCC1 | cellular response to radiation |
| HP:0200034 | 0.0388502441646 | 0.666666666667 | ERCC4 XPA | Papule |
| HP:0012795 | 0.0394523409679 | 1.0 | XPA ERCC4 ERCC1 | Abnormal optic disc morphology |
| HP:0000028 | 0.0407427395301 | 1.0 | XPA ERCC4 ERCC1 | Cryptorchidism |
| HP:0011492 | 0.0408514331117 | 0.666666666667 | ERCC4 XPA | Abnormal corneal stroma morphology |
| HP:0000963 | 0.0408514331117 | 0.666666666667 | ERCC4 XPA | Thin skin |
| HP:0000080 | 0.0424427653377 | 1.0 | XPA ERCC4 ERCC1 | Abnormality of reproductive system physiology |
| HP:0006297 | 0.0460733968082 | 0.666666666667 | ERCC4 ERCC1 | Enamel hypoplasia |
| HP:0012444 | 0.0474117601369 | 1.0 | XPA ERCC4 ERCC1 | Brain atrophy |
| HP:0002538 | 0.0478252330498 | 1.0 | XPA ERCC4 ERCC1 | Abnormal cerebral cortex morphology |
| HP:0000518 | 0.0490800611352 | 1.0 | XPA ERCC4 ERCC1 | Cataract |
| HP:0100699 | 0.0493566712329 | 0.666666666667 | ERCC4 ERCC1 | Scarring |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ERCC4 | ERCC1 | 0.999 | 0.24 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo fraction |
| ERCC4 | XPA | 0.994 | 0.158 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ERCC1 | XPA | 0.991 | 0.2 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes