hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_11842.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| WNT3A | Protein Wnt-3a | 5 | UniProt NCBI |
| TIMP2 | Metalloproteinase inhibitor 2 (CSC-21K) (Tissue inhibitor of metalloproteinases 2) (TIMP-2) | 5 | UniProt NCBI |
| WNT3 | Proto-oncogene Wnt-3 (Proto-oncogene Int-4 homolog) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4150 | 0.000238782367243 | 1.0 | WNT3 WNT3A | Wnt signaling in kidney disease |
| KEGG:05217 | 0.000241415996293 | 1.0 | WNT3 WNT3A | Basal cell carcinoma |
| REAC:R-HSA-3238698 | 0.000512628525639 | 1.0 | WNT3 WNT3A | WNT ligand biogenesis and trafficking |
| KEGG:04916 | 0.000553224670293 | 1.0 | WNT3 WNT3A | Melanogenesis |
| WP:WP4336 | 0.00114964558631 | 1.0 | WNT3 WNT3A | ncRNAs involved in Wnt signaling in hepatocellular carcinoma |
| KEGG:04550 | 0.00116074761854 | 1.0 | WNT3 WNT3A | Signaling pathways regulating pluripotency of stem cells |
| KEGG:04934 | 0.00125991513217 | 1.0 | WNT3 WNT3A | Cushing syndrome |
| KEGG:05224 | 0.00130072012548 | 1.0 | WNT3 WNT3A | Breast cancer |
| KEGG:05226 | 0.00138428094844 | 1.0 | WNT3 WNT3A | Gastric cancer |
| WP:WP4258 | 0.00144844277313 | 1.0 | WNT3 WNT3A | lncRNA in canonical Wnt signaling and colorectal cancer |
| KEGG:04390 | 0.001720800216 | 1.0 | WNT3 WNT3A | Hippo signaling pathway |
| KEGG:05206 | 0.00176843313648 | 1.0 | WNT3 WNT3A | MicroRNAs in cancer |
| KEGG:04150 | 0.00176843313648 | 1.0 | WNT3 WNT3A | mTOR signaling pathway |
| KEGG:04310 | 0.00181671633574 | 1.0 | WNT3 WNT3A | Wnt signaling pathway |
| WP:WP399 | 0.0018604594068 | 1.0 | WNT3 WNT3A | Wnt signaling pathway and pluripotency |
| KEGG:05225 | 0.00204203793228 | 1.0 | WNT3 WNT3A | Hepatocellular carcinoma |
| WP:WP3931 | 0.00210690324038 | 1.0 | WNT3 WNT3A | Embryonic stem cell pluripotency pathways |
| WP:WP428 | 0.0021494669422 | 1.0 | WNT3 WNT3A | Wnt signaling |
| WP:WP710 | 0.0021494669422 | 1.0 | WNT3 WNT3A | DNA damage response only ATM dependent |
| WP:WP4787 | 0.00219245628104 | 1.0 | WNT3 WNT3A | Osteoblast differentiation and related diseases |
| KEGG:05205 | 0.00267768543767 | 1.0 | WNT3 WNT3A | Proteoglycans in cancer |
| WP:WP2857 | 0.00340552178308 | 1.0 | WNT3 WNT3A | Mesodermal commitment pathway |
| WP:WP4239 | 0.00368005765986 | 1.0 | WNT3 WNT3A | Epithelial to mesenchymal transition in colorectal cancer |
| WP:WP4262 | 0.00373624174627 | 1.0 | WNT3 WNT3A | Breast cancer pathway |
| REAC:R-HSA-373080 | 0.00389255927135 | 1.0 | WNT3 WNT3A | Class B/2 (Secretin family receptors) |
| KEGG:05165 | 0.00700203931066 | 1.0 | WNT3 WNT3A | Human papillomavirus infection |
| KEGG:05010 | 0.0093688914925 | 1.0 | WNT3 WNT3A | Alzheimer disease |
| WP:WP2059 | 0.01130704739 | 1.0 | WNT3 WNT3A | Alzheimer 39 s disease and miRNA effects |
| WP:WP5124 | 0.01130704739 | 1.0 | WNT3 WNT3A | Alzheimer 39 s disease |
| KEGG:05022 | 0.0138982457502 | 1.0 | WNT3 WNT3A | Pathways of neurodegeneration - multiple diseases |
| KEGG:05200 | 0.0161326036311 | 1.0 | WNT3 WNT3A | Pathways in cancer |
| WP:WP5087 | 0.0293715080819 | 1.0 | WNT3 WNT3A | Pleural mesothelioma |
| REAC:R-HSA-201681 | 0.0364325093171 | 1.0 | WNT3 WNT3A | TCF dependent signaling in response to WNT |
| REAC:R-HSA-500792 | 0.0446089343011 | 1.0 | WNT3 WNT3A | GPCR ligand binding |
| WP:WP3930 | 0.049750157242 | 0.5 | WNT3 | EDA signaling in hair follicle development |
| HP:0005316 | 0.0499436884913 | 0.5 | WNT3 | Peripheral pulmonary vessel aplasia |
| HP:0003057 | 0.0499436884913 | 0.5 | WNT3 | Tetraamelia |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| WNT3 | WNT3A | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TIMP2 | WNT3A | 0.958 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| WNT3A | huMAP3_11842.1 huMAP3_14413.1 |
| TIMP2 | huMAP3_01505.1 huMAP3_11842.1 huMAP3_12426.1 huMAP3_12692.1 |
| WNT3 | huMAP3_01518.1 huMAP3_11842.1 huMAP3_12218.1 huMAP3_14413.1 huMAP3_15262.1 |