hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11847.1
Complex Portal: CPX-13874
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HOXC8 | Homeobox protein Hox-C8 (Homeobox protein Hox-3A) | 5 | UniProt NCBI |
| ANK3 | Ankyrin-3 (ANK-3) (Ankyrin-G) | 5 | UniProt NCBI |
| RAPGEF5 | Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF) (Related to Epac) (Repac) | 5 | UniProt NCBI |
| MAPK8IP2 | C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2) | 5 | UniProt NCBI |
| AHSP | Alpha-hemoglobin-stabilizing protein (Erythroid differentiation-related factor) (Erythroid-associated factor) | 5 | UniProt NCBI |
| MAPK8IP1 | C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain 1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1) | 5 | UniProt NCBI |
| MAPK8IP3 | C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3) | 5 | UniProt NCBI |
| TTLL4 | Tubulin monoglutamylase TTLL4 (EC 6.3.2.-) (Protein monoglutamylase TTLL4) (Tubulin--tyrosine ligase-like protein 4) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6994 | 2.39226645298e-05 | 0.25 | MAPK8IP2 MAPK8IP1 | JIP1-JIP2 complex |
| GO:0005078 | 0.000644767051209 | 0.375 | MAPK8IP2 MAPK8IP3 MAPK8IP1 | MAP-kinase scaffold activity |
| GO:0008432 | 0.000644767051209 | 0.375 | MAPK8IP2 MAPK8IP3 MAPK8IP1 | JUN kinase binding |
| KEGG:04010 | 0.0118329910642 | 0.375 | MAPK8IP2 MAPK8IP3 MAPK8IP1 | MAPK signaling pathway |
| WP:WP382 | 0.012445035572 | 0.375 | MAPK8IP2 MAPK8IP3 MAPK8IP1 | MAPK signaling pathway |
| GO:0019894 | 0.0195375863112 | 0.375 | MAPK8IP2 MAPK8IP3 MAPK8IP1 | kinesin binding |
| CORUM:4089 | 0.0499436884912 | 0.125 | HOXC8 | SMAD6-HOXC8 complex |
| CORUM:6618 | 0.0499436884912 | 0.125 | ANK3 | RhBG-kAE1-ankyrin-G complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MAPK8IP2 | MAPK8IP1 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TTLL4 | AHSP | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ANK3 | RAPGEF5 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| MAPK8IP2 | MAPK8IP3 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TTLL4 | MAPK8IP1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| MAPK8IP1 | ANK3 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TTLL4 | MAPK8IP2 | 0.992 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| HOXC8 | MAPK8IP1 | 0.992 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| MAPK8IP1 | MAPK8IP3 | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| MAPK8IP2 | RAPGEF5 | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| MAPK8IP2 | ANK3 | 0.984 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TTLL4 | ANK3 | 0.88 | 0.052 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| MAPK8IP2 | HOXC8 | 0.84 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| MAPK8IP3 | ANK3 | 0.634 | 0.038 | bioplex3_WMM WMM_only | |
| TTLL4 | MAPK8IP3 | 0.634 | 0.016 | bioplex3_WMM WMM_only | |
| TTLL4 | HOXC8 | 0.303 | bioplex_WMM bioplex3_WMM WMM_only | ||
| HOXC8 | ANK3 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only | ||
| HOXC8 | MAPK8IP3 | 0.131 | bioplex3_WMM WMM_only |
Related Complexes