hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11857.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MCAM | Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146) | 5 | UniProt NCBI |
| L1CAM | Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (CD antigen CD171) | 5 | UniProt NCBI |
| IGSF9 | Protein turtle homolog A (Immunoglobulin superfamily member 9A) (IgSF9A) | 5 | UniProt NCBI |
| TPBG | Trophoblast glycoprotein (5T4 oncofetal antigen) (5T4 oncofetal trophoblast glycoprotein) (5T4 oncotrophoblast glycoprotein) (M6P1) (Wnt-activated inhibitory factor 1) (WAIF1) | 5 | UniProt NCBI |
| JAG1 | Protein jagged-1 (Jagged1) (hJ1) (CD antigen CD339) | 5 | UniProt NCBI |
| CNTN1 | Contactin-1 (Glycoprotein gp135) (Neural cell surface protein F3) | 5 | UniProt NCBI |
| MEST | Mesoderm-specific transcript homolog protein (EC 3.-.-.-) (Paternally-expressed gene 1 protein) | 5 | UniProt NCBI |
| AREG | Amphiregulin (AR) (Colorectum cell-derived growth factor) (CRDGF) | 5 | UniProt NCBI |
| SNED1 | Sushi, nidogen and EGF-like domain-containing protein 1 (Insulin-responsive sequence DNA-binding protein 1) (IRE-BP1) | 5 | UniProt NCBI |
| IL6ST | Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130) | 5 | UniProt NCBI |
| CD101 | Immunoglobulin superfamily member 2 (IgSF2) (Cell surface glycoprotein V7) (Glu-Trp-Ile EWI motif-containing protein 101) (EWI-101) (CD antigen CD101) | 5 | UniProt NCBI |
| CTSZ | Cathepsin Z (EC 3.4.18.1) (Cathepsin P) (Cathepsin X) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-2979096 | 0.020280338984 | 0.181818181818 | JAG1 CNTN1 | NOTCH2 Activation and Transmission of Signal to the Nucleus |
| HPA:0460201 | 0.023026350104 | 0.454545454545 | JAG1 TPBG CTSZ MCAM L1CAM | skin 1; endothelial cells[>=Low] |
| HPA:0461441 | 0.0292249109202 | 0.454545454545 | JAG1 TPBG CTSZ MCAM L1CAM | skin 1; fibrohistiocytic cells[>=Low] |
| HPA:0470201 | 0.0295572080381 | 0.454545454545 | JAG1 TPBG CTSZ MCAM L1CAM | skin 2; endothelial cells[>=Low] |
| HPA:0090993 | 0.0314591821517 | 0.181818181818 | CNTN1 L1CAM | cerebellum; molecular layer - neuropil[High] |
| REAC:R-HSA-2122948 | 0.0364941063676 | 0.181818181818 | JAG1 CNTN1 | Activated NOTCH1 Transmits Signal to the Nucleus |
| REAC:R-HSA-1980145 | 0.0364941063676 | 0.181818181818 | JAG1 CNTN1 | Signaling by NOTCH2 |
| GO:0007155 | 0.0494189524924 | 0.636363636364 | CNTN1 IL6ST MCAM L1CAM JAG1 IGSF9 TPBG | cell adhesion |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| CNTN1 | MCAM | 0.994 | 0.07 |
| CNTN1 | L1CAM | 0.991 | |
| IL6ST | CD101 | 0.904 | |
| MCAM | SNED1 | 0.902 | |
| SNED1 | CD101 | 0.902 | |
| MCAM | CD101 | 0.902 | |
| TPBG | CD101 | 0.902 | |
| MEST | CD101 | 0.902 | |
| IGSF9 | CD101 | 0.902 | |
| JAG1 | CD101 | 0.902 | |
| L1CAM | CD101 | 0.896 | |
| TPBG | CTSZ | 0.862 | 0.024 |
| CD101 | CTSZ | 0.857 | |
| MCAM | IL6ST | 0.82 | 0.09 |
| MEST | CTSZ | 0.816 | 0.032 |
| SNED1 | CTSZ | 0.812 | |
| IGSF9 | CTSZ | 0.812 | |
| JAG1 | CTSZ | 0.812 | 0.07 |
| IL6ST | SNED1 | 0.768 | |
| CNTN1 | TPBG | 0.734 | 0.044 |
| CNTN1 | CTSZ | 0.734 | 0.058 |
| TPBG | SNED1 | 0.722 | |
| IGSF9 | SNED1 | 0.717 | |
| JAG1 | SNED1 | 0.717 | |
| CNTN1 | CD101 | 0.715 | |
| MEST | JAG1 | 0.714 | 0.082 |
| IGSF9 | MEST | 0.714 | |
| L1CAM | CTSZ | 0.701 | |
| MEST | SNED1 | 0.698 | |
| IGSF9 | JAG1 | 0.698 | |
| IGSF9 | MCAM | 0.696 | |
| MCAM | CTSZ | 0.694 | 0.054 |
| IL6ST | CTSZ | 0.68 | 0.022 |
| JAG1 | TPBG | 0.676 | 0.104 |
| IGSF9 | TPBG | 0.676 | |
| CNTN1 | SNED1 | 0.675 | |
| CNTN1 | MEST | 0.675 | 0.016 |
| IGSF9 | CNTN1 | 0.675 | |
| CNTN1 | JAG1 | 0.675 | 0.108 |
| CNTN1 | IL6ST | 0.648 | 0.098 |
| L1CAM | JAG1 | 0.633 | |
| MCAM | MEST | 0.626 | 0.066 |
| MCAM | TPBG | 0.572 | 0.16 |
| L1CAM | IL6ST | 0.49 | |
| MCAM | L1CAM | 0.49 | |
| MEST | TPBG | 0.468 | 0.062 |
| L1CAM | SNED1 | 0.468 | |
| IGSF9 | IL6ST | 0.427 | |
| IGSF9 | L1CAM | 0.421 | |
| IL6ST | TPBG | 0.419 | 0.034 |
| L1CAM | TPBG | 0.389 | |
| IL6ST | MEST | 0.388 | 0.066 |
| L1CAM | MEST | 0.378 | |
| IL6ST | JAG1 | 0.345 | 0.106 |
| MCAM | JAG1 | 0.21 | 0.286 |
Related Complexes