hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11871.1
Complex Portal: CPX-20325
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TCAIM | T-cell activation inhibitor, mitochondrial (Tolerance associated gene-1 protein) (TOAG-1) | 3 | UniProt NCBI |
| OGDHL | 2-oxoglutarate dehydrogenase-like, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1-like) (OGDC-E1-like) (Alpha-ketoglutarate dehydrogenase-like) | 5 | UniProt NCBI |
| ARMS2 | Age-related maculopathy susceptibility protein 2 | 3 | UniProt NCBI |
| KGD4 | Alpha-ketoglutarate dehydrogenase component 4 (Alpha-ketoglutarate dehydrogenase subunit 4) | 3 | UniProt NCBI |
| EXOC3L2 | Exocyst complex component 3-like protein 2 (HBV X-transactivated gene 7 protein) (HBV XAg-transactivated protein 7) | 3 | UniProt NCBI |
| PRR20C | Proline-rich protein 20C | 5 | UniProt NCBI |
| SIAH1 | E3 ubiquitin-protein ligase SIAH1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH1) (Seven in absentia homolog 1) (Siah-1) (Siah-1a) | 5 | UniProt NCBI |
| PAGE2B | Putative G antigen family E member 3 (Prostate-associated gene 2B protein) (PAGE-2B) | 2 | UniProt NCBI |
| DLD | Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein) | 5 | UniProt NCBI |
| DLST | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K) | 5 | UniProt NCBI |
| SIAH2 | E3 ubiquitin-protein ligase SIAH2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH2) (Seven in absentia homolog 2) (Siah-2) (hSiah2) | 5 | UniProt NCBI |
| OGDH | 2-oxoglutarate dehydrogenase complex component E1 (E1o) (OGDC-E1) (OGDH-E1) (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Alpha-KGDH-E1) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0045252 | 8.73008139488e-11 | 0.454545454545 | OGDH OGDHL DLD DLST KGD4 | oxoglutarate dehydrogenase complex |
| GO:0045240 | 1.91798962418e-09 | 0.454545454545 | OGDH OGDHL DLD DLST KGD4 | dihydrolipoyl dehydrogenase complex |
| GO:0045239 | 2.56367096242e-08 | 0.454545454545 | OGDH OGDHL DLD DLST KGD4 | tricarboxylic acid cycle enzyme complex |
| KEGG:00785 | 2.69401009935e-08 | 0.363636363636 | OGDH OGDHL DLST DLD | Lipoic acid metabolism |
| CORUM:7267 | 8.42140472852e-08 | 0.272727272727 | DLD DLST OGDH | KAT2A-Oxoglutarate dehydrogenase complex |
| KEGG:01210 | 2.40164148575e-07 | 0.363636363636 | OGDH OGDHL DLST DLD | 2-Oxocarboxylic acid metabolism |
| KEGG:00020 | 2.40164148575e-07 | 0.363636363636 | OGDH OGDHL DLST DLD | Citrate cycle (TCA cycle) |
| GO:0006103 | 6.18707875607e-06 | 0.363636363636 | OGDH OGDHL DLST KGD4 | 2-oxoglutarate metabolic process |
| REAC:R-HSA-71064 | 1.35144212718e-05 | 0.272727272727 | DLD DLST OGDH | Lysine catabolism |
| GO:0004591 | 1.58598067776e-05 | 0.272727272727 | OGDHL OGDH KGD4 | oxoglutarate dehydrogenase (succinyl-transferring) activity |
| WP:WP2453 | 1.84429866101e-05 | 0.272727272727 | DLD DLST OGDH | TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc |
| WP:WP78 | 2.68519924593e-05 | 0.272727272727 | DLD DLST OGDH | TCA cycle aka Krebs or citric acid cycle |
| KEGG:01200 | 3.9165862579e-05 | 0.363636363636 | OGDH OGDHL DLST DLD | Carbon metabolism |
| GO:0106077 | 6.34131776058e-05 | 0.272727272727 | DLD DLST OGDH | histone succinylation |
| GO:0018335 | 6.34131776058e-05 | 0.272727272727 | DLD DLST OGDH | protein succinylation |
| GO:0006099 | 9.15623696604e-05 | 0.363636363636 | OGDH OGDHL DLST KGD4 | tricarboxylic acid cycle |
| REAC:R-HSA-71403 | 0.00010848779128 | 0.272727272727 | DLD DLST OGDH | Citric acid cycle (TCA cycle) |
| REAC:R-HSA-389661 | 0.000187302344386 | 0.272727272727 | DLD DLST OGDH | Glyoxylate metabolism and glycine degradation |
| WP:WP5352 | 0.00052726211165 | 0.272727272727 | OGDHL DLST DLD | 10q11 21q11 23 copy number variation syndrome |
| GO:1990204 | 0.000537962056951 | 0.454545454545 | OGDH OGDHL DLD DLST KGD4 | oxidoreductase complex |
| GO:0016903 | 0.000782670774929 | 0.363636363636 | OGDHL DLD OGDH KGD4 | oxidoreductase activity, acting on the aldehyde or oxo group of donors |
| GO:0016624 | 0.000886327111509 | 0.272727272727 | OGDHL OGDH KGD4 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor |
| REAC:R-HSA-71406 | 0.0017798652926 | 0.272727272727 | DLD DLST OGDH | Pyruvate metabolism and Citric Acid (TCA) cycle |
| WP:WP3925 | 0.00294376640307 | 0.272727272727 | DLD DLST OGDH | Amino acid metabolism |
| WP:WP4932 | 0.00455328541335 | 0.272727272727 | DLD DLST OGDH | 7q11 23 copy number variation syndrome |
| GO:0043648 | 0.0053914775929 | 0.363636363636 | OGDH OGDHL DLST KGD4 | dicarboxylic acid metabolic process |
| HPA:0570811 | 0.0135487431109 | 0.727272727273 | KGD4 OGDHL DLST OGDH SIAH2 DLD PAGE2B SIAH1 | testis; spermatogonia cells[>=Low] |
| KEGG:00380 | 0.0136845552554 | 0.181818181818 | DLD DLST | Tryptophan metabolism |
| HPA:0360053 | 0.0358032207877 | 0.545454545455 | KGD4 SIAH1 OGDH DLST DLD OGDHL | parathyroid gland; glandular cells[High] |
| HP:0012401 | 0.0370282941421 | 0.181818181818 | DLD OGDH | Abnormal urine alpha-ketoglutarate concentration |
| KEGG:00310 | 0.0424043875552 | 0.181818181818 | DLD DLST | Lysine degradation |
| HPA:0570812 | 0.0447286981173 | 0.636363636364 | KGD4 SIAH2 DLST OGDH DLD PAGE2B OGDHL | testis; spermatogonia cells[>=Medium] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SIAH1 | SIAH2 | 1.0 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| OGDH | DLST | 1.0 | 0.658 |
mutually_exclusive (Q9ULD0)
|
hein_WMM bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo fraction boldt_WMM |
| OGDHL | DLD | 1.0 | 0.332 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| OGDH | KGD4 | 0.999 | 0.512 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| KGD4 | DLST | 0.999 | 0.336 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| OGDHL | DLST | 0.999 | 0.74 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| DLD | DLST | 0.998 | 0.736 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo fraction boldt_WMM treiber_WMM | |
| DLD | KGD4 | 0.998 | 0.346 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction |
| OGDHL | OGDH | 0.998 | 0.966 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| OGDHL | KGD4 | 0.997 | 0.53 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| DLD | OGDH | 0.995 | 0.478 |
mutually_exclusive (Q9ULD0)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| EXOC3L2 | SIAH1 | 0.994 | 0.084 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PRR20C | SIAH2 | 0.988 | bioplex3_HEK293 bioplex () bioplex_WMM | ||
| TCAIM | DLD | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| OGDHL | PAGE2B | 0.981 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SIAH1 | PRR20C | 0.981 | bioplex3_HEK293 bioplex () bioplex_WMM | ||
| SIAH1 | DLST | 0.979 | 0.068 |
structurally_consistent (O43255)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| SIAH2 | DLD | 0.965 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TCAIM | DLST | 0.965 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| SIAH1 | OGDHL | 0.965 | 0.078 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SIAH1 | KGD4 | 0.957 | 0.11 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| OGDHL | TCAIM | 0.956 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| SIAH1 | OGDH | 0.942 | 0.118 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TCAIM | KGD4 | 0.936 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| TCAIM | OGDH | 0.934 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| SIAH2 | DLST | 0.9 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| OGDHL | SIAH2 | 0.897 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SIAH2 | OGDH | 0.817 | bioplex_WMM bioplex3_WMM WMM_only | ||
| OGDHL | ARMS2 | 0.811 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| SIAH2 | KGD4 | 0.752 |
structurally_consistent (Q8IUQ4)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| PAGE2B | DLST | 0.704 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| SIAH1 | DLD | 0.657 | 0.0858235294118 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SIAH2 | TCAIM | 0.377 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PAGE2B | DLD | 0.319 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| SIAH1 | TCAIM | 0.224 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PAGE2B | KGD4 | 0.159 | bioplex3_WMM WMM_only | ||
| OGDH | ARMS2 | 0.13 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| PAGE2B | OGDH | 0.11 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| DLD | ARMS2 | 0.099 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| KGD4 | ARMS2 | 0.074 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| DLST | ARMS2 | 0.072 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| PAGE2B | TCAIM | 0.055 | bioplex3_WMM WMM_only | ||
| PRR20C | DLD | 0.017 | bioplex3_HEK293 bioplex () | ||
| PRR20C | DLST | 0.012 | bioplex3_HEK293 bioplex () | ||
| EXOC3L2 | DLD | 0.003 | 0.082 | bioplex3_HEK293 bioplex () |
Related Complexes