hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_11884.1

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
PKD2	Polycystin-2 (PC2) (Autosomal dominant polycystic kidney disease type II protein) (Polycystic kidney disease 2 protein) (Polycystwin) (R48321) (Transient receptor potential cation channel subfamily P member 2)	5	UniProt NCBI
TRPM8	Transient receptor potential cation channel subfamily M member 8 (Long transient receptor potential channel 6) (LTrpC-6) (LTrpC6) (Transient receptor potential p8) (Trp-p8)	5	UniProt NCBI
FAM3D	Protein FAM3D	3	UniProt NCBI
TRPM4	Transient receptor potential cation channel subfamily M member 4 (hTRPM4) (Calcium-activated non-selective cation channel 1) (Long transient receptor potential channel 4) (LTrpC-4) (LTrpC4) (Melastatin-4)	5	UniProt NCBI
PKD2L2	Polycystin-2-like protein 2 (Polycystin-2L2) (Polycystic kidney disease 2-like 2 protein) (Polycystin-L2)	5	UniProt NCBI
CNGA4	Cyclic nucleotide-gated cation channel alpha-4 (Cyclic nucleotide-gated channel alpha-4) (CNG channel alpha-4) (CNG-4) (CNG4)	5	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0005261	0.000135468209428	0.833333333333	TRPM4 CNGA4 PKD2L2 PKD2 TRPM8	monoatomic cation channel activity
GO:0005262	0.000450665620324	0.666666666667	TRPM4 PKD2L2 PKD2 TRPM8	calcium channel activity
GO:0005216	0.000537225298565	0.833333333333	TRPM4 CNGA4 PKD2L2 PKD2 TRPM8	monoatomic ion channel activity
GO:0099094	0.000792088897246	0.666666666667	TRPM4 CNGA4 PKD2 TRPM8	ligand-gated monoatomic cation channel activity
GO:0015267	0.000908281040922	0.833333333333	TRPM4 CNGA4 PKD2L2 PKD2 TRPM8	channel activity
GO:0022803	0.000923996225357	0.833333333333	TRPM4 CNGA4 PKD2L2 PKD2 TRPM8	passive transmembrane transporter activity
GO:0015085	0.000999031924798	0.666666666667	TRPM4 PKD2L2 PKD2 TRPM8	calcium ion transmembrane transporter activity
GO:0099604	0.00156505859778	0.5	TRPM4 PKD2 TRPM8	ligand-gated calcium channel activity
GO:0015276	0.00186589865871	0.666666666667	TRPM4 CNGA4 PKD2 TRPM8	ligand-gated monoatomic ion channel activity
GO:0022834	0.00186589865871	0.666666666667	TRPM4 CNGA4 PKD2 TRPM8	ligand-gated channel activity
GO:0008324	0.00297516014172	0.833333333333	TRPM4 CNGA4 PKD2L2 PKD2 TRPM8	monoatomic cation transmembrane transporter activity
REAC:R-HSA-3295583	0.0035019037522	0.333333333333	TRPM8 TRPM4	TRP channels
REAC:R-HSA-5620916	0.00393892248474	0.333333333333	CNGA4 PKD2	VxPx cargo-targeting to cilium
GO:0015075	0.00715811587239	0.833333333333	TRPM4 CNGA4 PKD2L2 PKD2 TRPM8	monoatomic ion transmembrane transporter activity
GO:0022836	0.0156557881857	0.666666666667	TRPM4 CNGA4 PKD2 TRPM8	gated channel activity
REAC:R-HSA-5620920	0.0265097243254	0.333333333333	CNGA4 PKD2	Cargo trafficking to the periciliary membrane
CORUM:1071	0.0499436884912	0.166666666667	PKD2	PKD2-FPC complex

Protein 1	Protein 2	Score	ProteomeHD	Evidence
TRPM4	CNGA4	0.998		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
PKD2	PKD2L2	0.996		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PKD2	CNGA4	0.957		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
TRPM4	TRPM8	0.944		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
TRPM4	PKD2L2	0.941		bioplex3_HEK293 bioplex3_WMM WMM_only
PKD2	FAM3D	0.837		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
TRPM4	PKD2	0.81	0.06	bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
PKD2	huMAP3_02572.1 huMAP3_06419.1 huMAP3_06570.1 huMAP3_10155.1 huMAP3_10624.1 huMAP3_11804.1 huMAP3_11884.1
TRPM8	huMAP3_11837.1 huMAP3_11884.1 huMAP3_14842.1
FAM3D	huMAP3_11777.1 huMAP3_11804.1 huMAP3_11884.1 huMAP3_13900.1 huMAP3_15285.1
TRPM4	huMAP3_00454.1 huMAP3_05584.1 huMAP3_06419.1 huMAP3_07829.1 huMAP3_08689.1 huMAP3_09336.1 huMAP3_10018.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11104.1 huMAP3_11349.1 huMAP3_11884.1
PKD2L2	huMAP3_02572.1 huMAP3_10155.1 huMAP3_10624.1 huMAP3_11804.1 huMAP3_11884.1
CNGA4	huMAP3_06419.1 huMAP3_06570.1 huMAP3_07829.1 huMAP3_09302.1 huMAP3_09734.1 huMAP3_10155.1 huMAP3_11884.1