hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11887.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TGM2 | Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Erythrocyte transglutaminase) (Heart G alpha(h)) (hhG alpha(h)) (Isopeptidase TGM2) (EC 3.4.-.-) (Protein G alpha(h)) (G(h)) (Protein-glutamine deamidase TGM2) (EC 3.5.1.44) (Protein-glutamine dopaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine histaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine noradrenalinyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine serotonyltransferase TGM2) (EC 2.3.1.-) (Tissue transglutaminase) (tTG) (tTgase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase H) (TGase H) (Transglutaminase II) (TGase II) (Transglutaminase-2) (TG2) (TGase-2) (hTG2) | 5 | UniProt NCBI |
| PLA2G2E | Group IIE secretory phospholipase A2 (GIIE sPLA2) (sPLA2-IIE) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 2E) | 5 | UniProt NCBI |
| MEPE | Matrix extracellular phosphoglycoprotein (Osteoblast/osteocyte factor 45) (OF45) (Osteoregulin) | 5 | UniProt NCBI |
| FN1 | Fibronectin (FN) (Cold-insoluble globulin) (CIG) [Cleaved into: Anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3] | 5 | UniProt NCBI |
| ITGA5 | Integrin alpha-5 (CD49 antigen-like family member E) (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) (CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2383 | 1.12081835382e-08 | 0.6 | TGM2 ITGA5 FN1 | ITGA5-ITGB1-FN1-TGM2 complex |
| CORUM:2376 | 1.36501667663e-05 | 0.4 | TGM2 FN1 | ITGA2B-ITGB3-FN1-TGM2 complex |
| CORUM:2375 | 1.36501667663e-05 | 0.4 | TGM2 FN1 | FN1-TGM2 complex |
| CORUM:2850 | 4.09448956317e-05 | 0.4 | FN1 ITGA5 | ITGA5-ITGB1-FN-1-NOV complex |
| KEGG:04512 | 4.44119474406e-05 | 0.6 | FN1 MEPE ITGA5 | ECM-receptor interaction |
| REAC:R-HSA-1566977 | 0.000151950811602 | 0.4 | FN1 ITGA5 | Fibronectin matrix formation |
| HPA:0641533 | 0.00306164759471 | 0.4 | TGM2 FN1 | endometrium; stromal fibroblasts[High] |
| WP:WP5300 | 0.00456408083355 | 0.4 | FN1 ITGA5 | TROP2 regulatory signaling |
| HPA:0640202 | 0.00481464032182 | 0.4 | TGM2 FN1 | endometrium; endothelial cells[>=Medium] |
| HPA:0641532 | 0.00481464032182 | 0.4 | TGM2 FN1 | endometrium; stromal fibroblasts[>=Medium] |
| HPA:0640201 | 0.00538768366829 | 0.4 | TGM2 FN1 | endometrium; endothelial cells[>=Low] |
| HPA:0640692 | 0.00568622014719 | 0.4 | TGM2 FN1 | endometrium; smooth muscle cells[>=Medium] |
| HPA:0641531 | 0.00599276207912 | 0.4 | TGM2 FN1 | endometrium; stromal fibroblasts[>=Low] |
| REAC:R-HSA-9634597 | 0.00953234360475 | 0.4 | FN1 ITGA5 | GPER1 signaling |
| REAC:R-HSA-1566948 | 0.00953234360475 | 0.4 | FN1 ITGA5 | Elastic fibre formation |
| HPA:0640691 | 0.0102944856463 | 0.4 | TGM2 FN1 | endometrium; smooth muscle cells[>=Low] |
| KEGG:05100 | 0.0128243509281 | 0.4 | FN1 ITGA5 | Bacterial invasion of epithelial cells |
| KEGG:05135 | 0.0293384756517 | 0.4 | FN1 ITGA5 | Yersinia infection |
| REAC:R-HSA-216083 | 0.0294410858888 | 0.4 | FN1 ITGA5 | Integrin cell surface interactions |
| HPA:0640000 | 0.0343425608627 | 0.4 | TGM2 FN1 | endometrium |
| CORUM:2882 | 0.0498708842806 | 0.2 | ITGA5 | ITGA5-ITGB3-COL6A3 complex |
| WP:WP4239 | 0.0499562127809 | 0.4 | FN1 ITGA5 | Epithelial to mesenchymal transition in colorectal cancer |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TGM2 | FN1 | 0.991 | 0.394 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| ITGA5 | TGM2 | 0.982 | 0.154 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| ITGA5 | PLA2G2E | 0.957 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| MEPE | FN1 | 0.944 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ITGA5 | FN1 | 0.942 | 0.17 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
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