hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11888.1
Complex Portal: CPX-19935
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UBL4A | Ubiquitin-like protein 4A (Ubiquitin-like protein GDX) | 5 | UniProt NCBI |
| SLC25A48 | Solute carrier family 25 member 48 | 5 | UniProt NCBI |
| TBX3 | T-box transcription factor TBX3 (T-box protein 3) | 5 | UniProt NCBI |
| HTR3E | 5-hydroxytryptamine receptor 3E (5-HT3-E) (5-HT3E) (Serotonin receptor 3E) | 5 | UniProt NCBI |
| PDE12 | 2',5'-phosphodiesterase 12 (2'-PDE) (2-PDE) (EC 3.1.4.-) (Mitochondrial deadenylase) (EC 3.1.13.4) | 5 | UniProt NCBI |
| SOX4 | Transcription factor SOX-4 | 5 | UniProt NCBI |
| GET4 | Golgi to ER traffic protein 4 homolog (Conserved edge-expressed protein) (Transmembrane domain recognition complex 35 kDa subunit) (TRC35) | 5 | UniProt NCBI |
| GET3 | ATPase GET3 (EC 3.6.-.-) (Arsenical pump-driving ATPase) (Arsenite-stimulated ATPase) (Guided entry of tail-anchored proteins factor 3, ATPase) (Transmembrane domain recognition complex 40 kDa ATPase subunit) (hARSA-I) (hASNA-I) | 5 | UniProt NCBI |
| BAG6 | Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe) | 5 | UniProt NCBI |
| CATSPERD | Cation channel sperm-associated auxiliary subunit delta (CatSper-delta) (CatSperdelta) (Transmembrane protein 146) | 5 | UniProt NCBI |
| ANKZF1 | tRNA endonuclease ANKZF1 (EC 3.1.-.-) (Ankyrin repeat and zinc finger domain-containing protein 1) (Zinc finger protein 744) | 5 | UniProt NCBI |
| TRAFD1 | TRAF-type zinc finger domain-containing protein 1 (Protein FLN29) | 4 | UniProt NCBI |
| UBL4B | Ubiquitin-like protein 4B | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03060 | 3.66838312054e-07 | 0.333333333333 | UBL4B GET3 GET4 BAG6 | Protein export |
| CORUM:6862 | 3.75927585468e-05 | 0.166666666667 | BAG6 GET4 | Bag6-Ubl4A-Trc35 Complex |
| REAC:R-HSA-9609523 | 6.39731551151e-05 | 0.25 | GET3 GET4 BAG6 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane |
| GO:0006620 | 0.00765826511887 | 0.25 | GET3 GET4 BAG6 | post-translational protein targeting to endoplasmic reticulum membrane |
| GO:0071816 | 0.0142868257683 | 0.25 | GET3 GET4 BAG6 | tail-anchored membrane protein insertion into ER membrane |
| REAC:R-HSA-9609507 | 0.0443112904678 | 0.25 | GET3 GET4 BAG6 | Protein localization |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| UBL4A | GET4 | 1.0 | 0.522 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 boldt_WMM |
| UBL4A | BAG6 | 1.0 | 0.302 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () Malo bioplex3_HCT116 fraction boldt_WMM |
| GET4 | BAG6 | 1.0 | 0.46 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 boldt_WMM |
| GET3 | GET4 | 1.0 | 0.128 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 boldt_WMM | |
| UBL4A | GET3 | 0.999 | 0.146 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 boldt_WMM | |
| GET3 | BAG6 | 0.998 | 0.094 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 boldt_WMM | |
| UBL4A | TRAFD1 | 0.987 | 0.038 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM | |
| UBL4B | BAG6 | 0.976 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PDE12 | GET4 | 0.972 | 0.096 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| UBL4A | TBX3 | 0.971 | 0.112 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| ANKZF1 | UBL4B | 0.971 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| UBL4A | HTR3E | 0.97 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 | ||
| TBX3 | BAG6 | 0.964 | 0.156 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| GET3 | TRAFD1 | 0.957 | 0.038 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| SLC25A48 | BAG6 | 0.916 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| GET4 | HTR3E | 0.89 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 | ||
| TRAFD1 | BAG6 | 0.882 | 0.038 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM | |
| GET3 | SLC25A48 | 0.882 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| GET3 | CATSPERD | 0.882 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PDE12 | BAG6 | 0.877 | 0.128 |
mutually_exclusive (P11441)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () |
| HTR3E | BAG6 | 0.871 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 | ||
| UBL4A | CATSPERD | 0.871 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| GET4 | CATSPERD | 0.871 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| UBL4B | GET4 | 0.857 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TRAFD1 | SOX4 | 0.846 | 0.028 | boldt boldt_WMM WMM_only | |
| GET4 | SLC25A48 | 0.835 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| BAG6 | CATSPERD | 0.833 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| UBL4A | UBL4B | 0.816 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TRAFD1 | GET4 | 0.783 | 0.026 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| UBL4A | SLC25A48 | 0.533 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| UBL4A | PDE12 | 0.518 | 0.328 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| TBX3 | GET4 | 0.192 | 0.116 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| UBL4A | ANKZF1 | 0.108 | 0.106 | bioplex3_WMM WMM_only | |
| ANKZF1 | BAG6 | 0.061 | 0.142 | bioplex3_WMM WMM_only | |
| ANKZF1 | GET4 | 0.057 | 0.034 | bioplex3_WMM WMM_only | |
| PDE12 | SOX4 | 0.054 | 0.084 | bioplex3_HEK293 WMM_only | |
| GET3 | PDE12 | 0.034 | 0.05 | bioplex_WMM bioplex3_WMM WMM_only | |
| GET3 | ANKZF1 | 0.022 | 0.044 | bioplex3_WMM WMM_only | |
| GET3 | HTR3E | 0.021 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| GET3 | UBL4B | 0.018 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| GET4 | SOX4 | 0.014 | 0.116 | bioplex3_HEK293 WMM_only | |
| UBL4A | SOX4 | 0.011 | 0.078 | boldt boldt_WMM WMM_only | |
| TRAFD1 | PDE12 | 0.008 | 0.022 | bioplex_WMM bioplex3_WMM WMM_only | |
| PDE12 | UBL4B | 0.007 | bioplex3_HEK293 bioplex3_HCT116 WMM_only | ||
| BAG6 | SOX4 | 0.005 | 0.082 | bioplex3_HEK293 boldt boldt_WMM WMM_only | |
| PDE12 | CATSPERD | 0.003 | bioplex3_HEK293 bioplex () bioplex3_HCT116 | ||
| PDE12 | SLC25A48 | 0.002 | bioplex3_HCT116 WMM_only | ||
| PDE12 | HTR3E | 0.002 | bioplex3_HCT116 WMM_only |
Related Complexes