hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11895.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CD8B | T-cell surface glycoprotein CD8 beta chain (CD antigen CD8b) | 5 | UniProt NCBI |
| FCER1A | High affinity immunoglobulin epsilon receptor subunit alpha (Fc-epsilon RI-alpha) (FcERI) (IgE Fc receptor subunit alpha) | 5 | UniProt NCBI |
| PRSS3 | Trypsin-3 (EC 3.4.21.4) (Brain trypsinogen) (Mesotrypsin) (Mesotrypsinogen) (Serine protease 3) (Serine protease 4) (Trypsin III) (Trypsin IV) | 5 | UniProt NCBI |
| PRSS1 | Serine protease 1 (EC 3.4.21.4) (Anionic trypsin I) (Anionic trypsin-I) (Beta-trypsin) (Cationic trypsinogen) (Pretrypsinogen I) (Trypsin I) (Trypsin-1) [Cleaved into: Alpha-trypsin chain 1; Alpha-trypsin chain 2] | 5 | UniProt NCBI |
| DKK2 | Dickkopf-related protein 2 (Dickkopf-2) (Dkk-2) (hDkk-2) | 4 | UniProt NCBI |
| PRSS2 | Trypsin-2 (EC 3.4.21.4) (Anionic trypsinogen) (Serine protease 2) (Trypsin II) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04974 | 1.79251891439e-05 | 0.75 | PRSS3 PRSS1 PRSS2 | Protein digestion and absorption |
| KEGG:04972 | 2.04010593609e-05 | 0.75 | PRSS3 PRSS1 PRSS2 | Pancreatic secretion |
| HP:0005206 | 0.000100319571443 | 0.5 | PRSS2 PRSS1 | Pancreatic pseudocyst |
| KEGG:05164 | 0.000166087532962 | 0.75 | PRSS3 PRSS1 PRSS2 | Influenza A |
| HP:0005213 | 0.000200620835246 | 0.5 | PRSS2 PRSS1 | Pancreatic calcification |
| REAC:R-HSA-9758881 | 0.000215205765992 | 0.5 | PRSS3 PRSS1 | Uptake of dietary cobalamins into enterocytes |
| HPA:0481353 | 0.000242753520555 | 0.75 | PRSS3 PRSS1 PRSS2 | small intestine; paneth cells[High] |
| REAC:R-HSA-1462054 | 0.000286914834749 | 0.5 | PRSS3 PRSS2 | Alpha-defensins |
| HPA:0151353 | 0.000288400057236 | 0.75 | PRSS3 PRSS1 PRSS2 | duodenum; paneth cells[High] |
| KEGG:04080 | 0.000364678239794 | 0.75 | PRSS3 PRSS1 PRSS2 | Neuroactive ligand-receptor interaction |
| HPA:0481352 | 0.000707203808532 | 0.75 | PRSS3 PRSS1 PRSS2 | small intestine; paneth cells[>=Medium] |
| HPA:0151352 | 0.000963037392015 | 0.75 | PRSS3 PRSS1 PRSS2 | duodenum; paneth cells[>=Medium] |
| TF:M03886_1 | 0.000998468305694 | 0.75 | PRSS3 PRSS1 PRSS2 | Factor: Sox-2; motif: NNCCWTTGTTNTKN; match class: 1 |
| HPA:0481351 | 0.00107468477047 | 0.75 | PRSS3 PRSS1 PRSS2 | small intestine; paneth cells[>=Low] |
| REAC:R-HSA-196741 | 0.00122873738811 | 0.5 | PRSS3 PRSS1 | Cobalamin (Cbl, vitamin B12) transport and metabolism |
| HPA:0151351 | 0.00125776639967 | 0.75 | PRSS3 PRSS1 PRSS2 | duodenum; paneth cells[>=Low] |
| REAC:R-HSA-1461973 | 0.00236402400204 | 0.5 | PRSS3 PRSS2 | Defensins |
| REAC:R-HSA-1592389 | 0.00282403231951 | 0.5 | PRSS2 PRSS1 | Activation of Matrix Metalloproteinases |
| HP:0100027 | 0.00350734148159 | 0.5 | PRSS2 PRSS1 | Recurrent pancreatitis |
| HP:0030247 | 0.0051092979876 | 0.5 | PRSS2 PRSS1 | Splanchnic vein thrombosis |
| REAC:R-HSA-6803157 | 0.0162811003561 | 0.5 | PRSS3 PRSS2 | Antimicrobial peptides |
| HP:0011227 | 0.03008608933 | 0.5 | PRSS2 PRSS1 | Elevated circulating C-reactive protein concentration |
| HP:0032436 | 0.0329787201379 | 0.5 | PRSS2 PRSS1 | Abnormal circulating C-reactive protein concentration |
| HP:0002570 | 0.0375654511359 | 0.5 | PRSS2 PRSS1 | Steatorrhea |
| HP:0002630 | 0.040788355352 | 0.5 | PRSS2 PRSS1 | Fat malabsorption |
| GO:0004252 | 0.048062454325 | 0.75 | PRSS3 PRSS1 PRSS2 | serine-type endopeptidase activity |
| TF:M13133 | 0.0496619752722 | 0.75 | PRSS3 PRSS1 PRSS2 | Factor: GABPBETA; motif: NGMTGATGCAAYN |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PRSS3 | PRSS2 | 0.997 | 0.44 | hein_WMM bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| FCER1A | PRSS2 | 0.993 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CD8B | PRSS2 | 0.978 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PRSS1 | PRSS2 | 0.953 | 0.372 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| DKK2 | PRSS2 | 0.948 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PRSS3 | PRSS1 | 0.343 | 0.278 | bioplex3_WMM WMM_only boldt_WMM |
Related Complexes