hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_11899.1

Complex Portal: CPX-15260

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
CHP2	Calcineurin B homologous protein 2 (Hepatocellular carcinoma-associated antigen 520)	5	UniProt NCBI
ITGB3BP	Centromere protein R (CENP-R) (Beta-3-endonexin) (Integrin beta-3-binding protein) (Nuclear receptor-interacting factor 3)	5	UniProt NCBI
CENPM	Centromere protein M (CENP-M) (Interphase centromere complex protein 39) (Proliferation-associated nuclear element protein 1)	5	UniProt NCBI
CENPT	Centromere protein T (CENP-T) (Interphase centromere complex protein 22)	5	UniProt NCBI
CENPQ	Centromere protein Q (CENP-Q)	5	UniProt NCBI
CENPU	Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1)	5	UniProt NCBI
CENPO	Centromere protein O (CENP-O) (Interphase centromere complex protein 36)	5	UniProt NCBI
CENPK	Centromere protein K (CENP-K) (Interphase centromere complex protein 37) (Protein AF-5alpha) (p33)	5	UniProt NCBI
MRPS26	Small ribosomal subunit protein mS26 (28S ribosomal protein S13, mitochondrial) (MRP-S13) (S13mt) (28S ribosomal protein S26, mitochondrial) (MRP-S26) (S26mt)	4	UniProt NCBI
ZFY	Zinc finger Y-chromosomal protein	5	UniProt NCBI
CENPP	Centromere protein P (CENP-P)	5	UniProt NCBI
EEIG2	EEIG family member 2 (EEIG2)	2	UniProt NCBI
CENPI	Centromere protein I (CENP-I) (FSH primary response protein 1) (Follicle-stimulating hormone primary response protein) (Interphase centromere complex protein 19) (Leucine-rich primary response protein 1)	5	UniProt NCBI
CENPL	Centromere protein L (CENP-L) (Interphase centromere complex protein 33)	5	UniProt NCBI
CENPH	Centromere protein H (CENP-H) (Interphase centromere complex protein 35)	5	UniProt NCBI
ZFX	Zinc finger X-chromosomal protein	5	UniProt NCBI
TBC1D13	TBC1 domain family member 13	4	UniProt NCBI
CENPW	Centromere protein W (CENP-W) (Cancer-up-regulated gene 2 protein)	5	UniProt NCBI
CENPN	Centromere protein N (CENP-N) (Interphase centromere complex protein 32)	5	UniProt NCBI
CENPX	Centromere protein X (CENP-X) (FANCM-associated histone fold protein 2) (FANCM-interacting histone fold protein 2) (Fanconi anemia-associated polypeptide of 10 kDa) (Retinoic acid-inducible gene D9 protein homolog) (Stimulated by retinoic acid gene 13 protein homolog)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0000939	3.01514667242e-37	0.736842105263	CENPH CENPW CENPQ CENPX ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	inner kinetochore
CORUM:7394	1.77877305904e-32	0.578947368421	CENPH CENPQ ITGB3BP CENPL CENPP CENPM CENPU CENPI CENPN CENPK CENPO	CENP-H-I complex
CORUM:1179	1.38604989773e-30	0.578947368421	CENPH CENPQ ITGB3BP CENPL CENPP CENPM CENPU CENPT CENPN CENPK CENPO	CENP-A NAC-CAD complex
REAC:R-HSA-774815	3.33874156154e-28	0.736842105263	CENPH CENPW CENPQ CENPX ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	Nucleosome assembly
REAC:R-HSA-606279	3.33874156154e-28	0.736842105263	CENPH CENPW CENPQ CENPX ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	Deposition of new CENPA-containing nucleosomes at the centromere
REAC:R-HSA-73886	2.24879601346e-23	0.736842105263	CENPH CENPW CENPQ CENPX ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	Chromosome Maintenance
GO:0000776	1.14419173638e-20	0.736842105263	CENPH CENPW CENPQ CENPX ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	kinetochore
GO:0000779	1.74451291928e-20	0.736842105263	CENPH CENPW CENPQ CENPX ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	condensed chromosome, centromeric region
REAC:R-HSA-141424	2.67657841655e-20	0.631578947368	CENPH CENPQ ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	Amplification of signal from the kinetochores
REAC:R-HSA-141444	2.67657841655e-20	0.631578947368	CENPH CENPQ ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
REAC:R-HSA-69618	2.04257804436e-19	0.631578947368	CENPH CENPQ ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	Mitotic Spindle Checkpoint
REAC:R-HSA-9648025	3.61157042835e-19	0.631578947368	CENPH CENPQ ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	EML4 and NUDC in mitotic spindle formation
REAC:R-HSA-2500257	8.52296598455e-19	0.631578947368	CENPH CENPQ ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	Resolution of Sister Chromatid Cohesion
GO:0000775	2.08803549202e-18	0.736842105263	CENPH CENPW CENPQ CENPX ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	chromosome, centromeric region
REAC:R-HSA-5663220	2.52901811193e-18	0.631578947368	CENPH CENPQ ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	RHO GTPases Activate Formins
GO:0000793	3.71649745434e-18	0.736842105263	CENPH CENPW CENPQ CENPX ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	condensed chromosome
REAC:R-HSA-2467813	1.54314541776e-16	0.631578947368	CENPH CENPQ ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	Separation of Sister Chromatids
REAC:R-HSA-68877	3.14797558782e-16	0.631578947368	CENPH CENPQ ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	Mitotic Prometaphase
REAC:R-HSA-68882	1.62552354152e-15	0.631578947368	CENPH CENPQ ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	Mitotic Anaphase
REAC:R-HSA-2555396	1.71676443871e-15	0.631578947368	CENPH CENPQ ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	Mitotic Metaphase and Anaphase
GO:0098687	2.21125599505e-15	0.736842105263	CENPH CENPW CENPQ CENPX ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	chromosomal region
GO:0007059	2.63886531723e-15	0.736842105263	CENPH CENPW CENPQ CENPX ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	chromosome segregation
REAC:R-HSA-69620	2.47907147684e-14	0.631578947368	CENPH CENPQ ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	Cell Cycle Checkpoints
REAC:R-HSA-195258	5.07316134992e-14	0.631578947368	CENPH CENPQ ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	RHO GTPase Effectors
REAC:R-HSA-1640170	2.74637024606e-13	0.736842105263	CENPH CENPW CENPQ CENPX ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	Cell Cycle
CORUM:929	3.59586306466e-13	0.368421052632	CENPH CENPO CENPL CENPU CENPI CENPK CENPM	CEN complex
CORUM:927	4.79173042039e-13	0.263157894737	CENPH CENPT CENPN CENPM CENPU	CENP-A NAC complex
REAC:R-HSA-68886	1.28163828979e-12	0.631578947368	CENPH CENPQ ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	M Phase
REAC:R-HSA-69278	5.00632539167e-11	0.631578947368	CENPH CENPQ ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	Cell Cycle, Mitotic
CORUM:7388	6.29483581627e-11	0.263157894737	CENPH CENPT CENPN CENPL CENPI	CENP-A nucleosomal complex
REAC:R-HSA-194315	4.24807681611e-10	0.631578947368	CENPH CENPQ ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	Signaling by Rho GTPases
REAC:R-HSA-9716542	5.50731751689e-10	0.631578947368	CENPH CENPQ ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	Signaling by Rho GTPases, Miro GTPases and RHOBTB3
GO:0099080	2.878943056e-09	0.736842105263	CENPH CENPW CENPQ CENPX ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	supramolecular complex
GO:0022402	1.43982209512e-08	0.736842105263	CENPH CENPW CENPQ CENPX ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	cell cycle process
GO:0005694	6.34353006821e-08	0.789473684211	CENPH CENPW CENPQ CENPX CENPI ITGB3BP CENPL CENPP CENPM ZFY CENPU CENPT CENPN CENPK CENPO	chromosome
CORUM:6146	2.84164363312e-07	0.157894736842	CENPT CENPX CENPW	CENP-T-W-S-X heterotetramer complex
GO:0007049	4.31288968921e-07	0.736842105263	CENPH CENPW CENPQ CENPX ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	cell cycle
CORUM:6144	6.11162772017e-05	0.105263157895	CENPT CENPW	CENP-T-W complex
GO:0005654	0.000239777797105	0.894736842105	CENPH CENPW CENPQ CENPX MRPS26 CENPI ITGB3BP CENPK CENPP CENPM ZFY CENPT CENPO CENPL CENPN CHP2 CENPU	nucleoplasm
REAC:R-HSA-162582	0.000282400739174	0.631578947368	CENPH CENPQ ITGB3BP CENPL CENPP CENPM CENPI CENPU CENPT CENPN CENPK CENPO	Signal Transduction
GO:0043232	0.000371891268531	0.894736842105	CENPH CENPW CENPQ CENPX MRPS26 CENPI ITGB3BP CENPK CENPP CENPM ZFY CENPT CENPO CENPL CENPN CHP2 CENPU	intracellular non-membrane-bounded organelle
GO:0043228	0.000371891268531	0.894736842105	CENPH CENPW CENPQ CENPX MRPS26 CENPI ITGB3BP CENPK CENPP CENPM ZFY CENPT CENPO CENPL CENPN CHP2 CENPU	non-membrane-bounded organelle
GO:0031981	0.000690638277052	0.894736842105	CENPH CENPW CENPQ CENPX MRPS26 CENPI ITGB3BP CENPK CENPP CENPM ZFY CENPT CENPO CENPL CENPN CHP2 CENPU	nuclear lumen
GO:0070013	0.0227513058361	0.894736842105	CENPH CENPW CENPQ CENPX MRPS26 CENPI ITGB3BP CENPK CENPP CENPM ZFY CENPT CENPO CENPL CENPN CHP2 CENPU	intracellular organelle lumen
GO:0043233	0.0227513058361	0.894736842105	CENPH CENPW CENPQ CENPX MRPS26 CENPI ITGB3BP CENPK CENPP CENPM ZFY CENPT CENPO CENPL CENPN CHP2 CENPU	organelle lumen
GO:0031974	0.0227513058361	0.894736842105	CENPH CENPW CENPQ CENPX MRPS26 CENPI ITGB3BP CENPK CENPP CENPM ZFY CENPT CENPO CENPL CENPN CHP2 CENPU	membrane-enclosed lumen

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
CENPO	CENPP	1.0	0.376	structurally_consistent (Q96H22)
CENPK	CENPH	1.0	0.43
ITGB3BP	CENPP	1.0	0.298
CENPU	ITGB3BP	1.0	0.25
CENPH	CENPI	1.0	0.328
CENPU	CENPQ	1.0	0.524
CENPQ	CENPP	1.0	0.302
CENPO	ITGB3BP	0.999	0.218
CENPU	CENPO	0.999	0.364
CENPU	CENPP	0.999	0.212	structurally_consistent (dimer)
CENPO	CENPQ	0.999	0.462
ITGB3BP	CENPQ	0.999	0.302
CENPK	CENPI	0.999	0.206
CENPU	CENPI	0.999	0.268
ITGB3BP	CENPT	0.998	0.156
CENPU	CENPT	0.998	0.19
CENPP	CENPH	0.998	0.284
CENPH	CENPM	0.998	0.26
CENPN	ITGB3BP	0.998	0.21
CENPQ	CENPI	0.998	0.316	structurally_consistent (Q8N0S6)
CENPN	CENPQ	0.998	0.286
CENPN	CENPI	0.998	0.238
CENPO	CENPT	0.997	0.36
CENPO	CENPI	0.996	0.256
CENPT	CENPQ	0.996	0.172
CENPI	CENPM	0.996	0.138
CENPN	CENPU	0.996	0.322
CENPN	CENPO	0.996	0.38	structurally_consistent (dimer)
CENPU	CENPH	0.996	0.194
CENPT	CENPH	0.995	0.26
CENPU	CENPX	0.995	0.168
ITGB3BP	CENPH	0.995	0.196
CENPQ	CENPX	0.994	0.124
CENPO	CENPX	0.994	0.156
CENPN	CENPT	0.993	0.218
ITGB3BP	CENPX	0.993	0.106
CENPK	CENPM	0.993	0.22	structurally_consistent (dimer)
CENPO	CENPH	0.993	0.172
ITGB3BP	CENPI	0.993	0.206
CENPQ	CENPH	0.992	0.424
CENPP	CENPX	0.991	0.152
CENPT	CENPI	0.99	0.168
CENPP	CENPI	0.99	0.156
CENPN	CENPH	0.989	0.228
CENPL	CENPQ	0.988	0.176	structurally_consistent (dimer)
CENPN	MRPS26	0.987	0.056
CENPN	CENPP	0.985	0.258	structurally_consistent (dimer)
TBC1D13	CENPM	0.984	0.054
CENPT	CENPP	0.984	0.138
ZFX	CENPU	0.983	0.138
ZFX	CENPI	0.973	0.108
ZFX	ZFY	0.972
CENPL	CENPI	0.966	0.218	structurally_consistent (dimer)
ITGB3BP	CENPK	0.965	0.194
CENPO	CENPK	0.962	0.264
CENPU	CENPK	0.962	0.228
CENPN	CENPL	0.961	0.276	structurally_consistent (dimer)
MRPS26	CENPQ	0.961	0.268
MRPS26	EEIG2	0.96	0.024
CENPQ	CENPK	0.96	0.352
CENPQ	CENPM	0.959	0.17
CENPU	CENPL	0.956	0.216	structurally_consistent (Q6IPU0)
CENPO	CENPM	0.953	0.184	structurally_consistent (Q96H22)
MRPS26	ITGB3BP	0.952	0.198
CENPU	MRPS26	0.952	0.088
MRPS26	CENPO	0.943	0.088
MRPS26	CENPP	0.942	0.124
CENPL	MRPS26	0.938	0.112
CENPL	CENPO	0.938	0.308	structurally_consistent (Q96H22)
CENPL	ITGB3BP	0.931	0.22
ZFX	CENPO	0.925	0.118
MRPS26	CENPT	0.923	0.046
MRPS26	CENPI	0.923	0.116
CENPX	CHP2	0.915
CENPU	CENPM	0.915	0.266
ZFX	CENPN	0.898	0.1
CENPX	CENPH	0.886	0.212
ZFX	ITGB3BP	0.852	0.118
CENPH	CENPW	0.848
ZFX	CENPQ	0.845	0.098
CENPT	CENPW	0.794
CENPT	CENPK	0.785	0.166
CENPP	CENPM	0.785	0.172
CENPP	CENPK	0.785	0.22
CENPT	CENPM	0.785	0.136
CENPN	CENPM	0.785	0.136	structurally_consistent (dimer)
CENPN	CENPK	0.785	0.224	structurally_consistent (Q9NSP4)
ITGB3BP	CENPM	0.785	0.226
CENPL	CENPH	0.765	0.252
CENPX	CENPK	0.764	0.226
CENPT	CENPX	0.764	0.166
CENPX	CENPM	0.764	0.148
CENPX	CENPI	0.764	0.124
CENPN	CENPX	0.764	0.134
MRPS26	CENPH	0.707	0.284
MRPS26	CENPM	0.437	0.102
CENPQ	CENPW	0.423
CENPL	CENPW	0.315
MRPS26	CENPW	0.248
ZFX	CENPM	0.232	0.062
ZFX	CENPT	0.232	0.104
ZFX	CENPX	0.232	0.062
ZFX	CENPH	0.232	0.112
ZFX	CENPP	0.232	0.112
ZFX	CENPK	0.232	0.118
CENPL	CENPX	0.192	0.134
CENPM	CENPW	0.192
CENPU	CENPW	0.192
CENPL	CENPT	0.192	0.16
ITGB3BP	CENPW	0.192
CENPK	CENPW	0.192
CENPN	CENPW	0.192
EEIG2	CENPW	0.192
CENPL	CENPP	0.192	0.294	structurally_consistent (dimer)
CENPP	CENPW	0.192
CENPX	CENPW	0.192
CENPL	CENPK	0.192	0.182
CENPL	CENPM	0.192	0.148
CENPI	CENPW	0.192
CENPL	EEIG2	0.192	0.096
CENPO	CENPW	0.192
ZFX	MRPS26	0.152	0.106
ZFX	CENPL	0.135	0.09
CENPH	EEIG2	0.095	0.066
MRPS26	CENPK	0.084	0.054
ZFY	CENPQ	0.076
ZFY	CENPO	0.076
ZFY	MRPS26	0.07
EEIG2	CENPM	0.063	0.058
MRPS26	CENPX	0.063	0.104
CENPO	EEIG2	0.063	0.096
CENPN	EEIG2	0.063	0.106
CENPQ	EEIG2	0.063	0.082
CENPT	EEIG2	0.063	0.116
CENPP	EEIG2	0.063	0.054
ITGB3BP	EEIG2	0.063	0.076
CENPU	ZFY	0.052
CENPI	EEIG2	0.049	0.166
CENPU	EEIG2	0.049	0.09
CENPX	EEIG2	0.049	0.096
CENPK	EEIG2	0.048	0.086

Related Complexes

Genename	Complexes
CHP2	huMAP3_11582.1 huMAP3_11696.1 huMAP3_11899.1 huMAP3_11995.1 huMAP3_12695.1 huMAP3_13031.1 huMAP3_13592.1 huMAP3_14509.1 huMAP3_14808.1 huMAP3_15172.1
ITGB3BP	huMAP3_04053.1 huMAP3_06427.1 huMAP3_09807.1 huMAP3_11899.1 huMAP3_14808.1
CENPM	huMAP3_09807.1 huMAP3_11899.1 huMAP3_12305.1 huMAP3_13642.1 huMAP3_14808.1
CENPT	huMAP3_04053.1 huMAP3_06427.1 huMAP3_09807.1 huMAP3_11899.1 huMAP3_14808.1
CENPQ	huMAP3_04053.1 huMAP3_06427.1 huMAP3_09807.1 huMAP3_11899.1 huMAP3_14808.1
CENPU	huMAP3_01056.1 huMAP3_06427.1 huMAP3_09807.1 huMAP3_11899.1 huMAP3_14808.1
CENPO	huMAP3_04053.1 huMAP3_06427.1 huMAP3_09807.1 huMAP3_11899.1 huMAP3_14808.1
CENPK	huMAP3_04427.1 huMAP3_06427.1 huMAP3_09807.1 huMAP3_11899.1 huMAP3_14808.1
MRPS26	huMAP3_02367.1 huMAP3_05807.1 huMAP3_05954.1 huMAP3_11899.1
ZFY	huMAP3_02155.1 huMAP3_02433.1 huMAP3_04594.1 huMAP3_10388.1 huMAP3_11209.1 huMAP3_11265.1 huMAP3_11899.1 huMAP3_12625.1
CENPP	huMAP3_04053.1 huMAP3_06427.1 huMAP3_09807.1 huMAP3_11899.1 huMAP3_14808.1
EEIG2	huMAP3_04849.1 huMAP3_11899.1
CENPI	huMAP3_04427.1 huMAP3_06427.1 huMAP3_09807.1 huMAP3_11265.1 huMAP3_11899.1 huMAP3_14808.1
CENPL	huMAP3_01056.1 huMAP3_06427.1 huMAP3_09807.1 huMAP3_11899.1 huMAP3_14808.1
CENPH	huMAP3_04427.1 huMAP3_06427.1 huMAP3_09807.1 huMAP3_11899.1 huMAP3_13975.1 huMAP3_14808.1
ZFX	huMAP3_01056.1 huMAP3_02155.1 huMAP3_04594.1 huMAP3_06427.1 huMAP3_09807.1 huMAP3_11265.1 huMAP3_11899.1 huMAP3_14808.1
TBC1D13	huMAP3_04880.1 huMAP3_11899.1 huMAP3_12305.1 huMAP3_13642.1 huMAP3_14808.1 huMAP3_14813.1
CENPW	huMAP3_11899.1 huMAP3_13975.1 huMAP3_14808.1
CENPN	huMAP3_01056.1 huMAP3_06427.1 huMAP3_09807.1 huMAP3_11899.1 huMAP3_14808.1
CENPX	huMAP3_04053.1 huMAP3_06427.1 huMAP3_09167.1 huMAP3_09780.1 huMAP3_09807.1 huMAP3_09816.1 huMAP3_11696.1 huMAP3_11899.1 huMAP3_12695.1 huMAP3_13031.1 huMAP3_14509.1 huMAP3_14808.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_11899.1

Complex Portal: CPX-15260