hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_11905.1
Complex Portal: CPX-23501
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PGAM4 | Probable phosphoglycerate mutase 4 (EC 5.4.2.11) (EC 5.4.2.4) | 4 | UniProt NCBI |
| BPGM | Bisphosphoglycerate mutase (BPGM) (EC 5.4.2.4) (2,3-bisphosphoglycerate mutase, erythrocyte) (2,3-bisphosphoglycerate synthase) (EC 5.4.2.11) (2,3-diphosphoglycerate mutase) (DPGM) (BPG-dependent PGAM) | 5 | UniProt NCBI |
| PGAM1 | Phosphoglycerate mutase 1 (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM 1) (Phosphoglycerate mutase isozyme B) (PGAM-B) | 5 | UniProt NCBI |
| KLF16 | Krueppel-like factor 16 (Basic transcription element-binding protein 4) (BTE-binding protein 4) (Novel Sp1-like zinc finger transcription factor 2) (Transcription factor BTEB4) (Transcription factor NSLP2) | 4 | UniProt NCBI |
| PGAM2 | Phosphoglycerate mutase 2 (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM 2) (Muscle-specific phosphoglycerate mutase) (Phosphoglycerate mutase isozyme M) (PGAM-M) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00260 | 1.87008360524e-06 | 0.75 | PGAM4 BPGM PGAM1 | Glycine, serine and threonine metabolism |
| KEGG:00010 | 1.2943754201e-05 | 0.75 | PGAM4 BPGM PGAM1 | Glycolysis / Gluconeogenesis |
| GO:0016868 | 3.22863876272e-05 | 0.75 | PGAM4 BPGM PGAM1 | intramolecular phosphotransferase activity |
| GO:0016866 | 0.000680215375943 | 0.75 | PGAM4 BPGM PGAM1 | intramolecular transferase activity |
| GO:0004082 | 0.0028092043205 | 0.5 | PGAM1 BPGM | bisphosphoglycerate mutase activity |
| KEGG:01230 | 0.00551283411821 | 0.5 | PGAM4 PGAM1 | Biosynthesis of amino acids |
| KEGG:05230 | 0.00551283411821 | 0.5 | PGAM4 PGAM1 | Central carbon metabolism in cancer |
| GO:0004619 | 0.00842684400117 | 0.5 | PGAM4 PGAM1 | phosphoglycerate mutase activity |
| KEGG:04922 | 0.0104133784038 | 0.5 | PGAM4 PGAM1 | Glucagon signaling pathway |
| KEGG:01200 | 0.0133093129958 | 0.5 | PGAM4 PGAM1 | Carbon metabolism |
| REAC:R-HSA-70171 | 0.0212029570934 | 0.5 | PGAM1 BPGM | Glycolysis |
| REAC:R-HSA-70326 | 0.0313666733646 | 0.5 | PGAM1 BPGM | Glucose metabolism |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PGAM2 | PGAM4 | 1.0 |
mutually_exclusive (P07738)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PGAM1 | BPGM | 0.999 | 0.144 |
mutually_exclusive (P15259)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PGAM2 | PGAM1 | 0.999 |
mutually_exclusive (P07738)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| PGAM1 | PGAM4 | 0.997 | 0.2 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| PGAM4 | BPGM | 0.992 | 0.048 |
mutually_exclusive (P15259)
structurally_consistent (dimer) |
bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| BPGM | KLF16 | 0.989 | 0.03 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PGAM2 | BPGM | 0.986 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PGAM1 | KLF16 | 0.311 | 0.106 |
structurally_consistent (P07738)
|
bioplex_WMM bioplex3_WMM WMM_only |
| PGAM4 | KLF16 | 0.051 | 0.084 |
structurally_consistent (P07738)
|
bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| PGAM4 | huMAP3_04142.1 huMAP3_11712.1 huMAP3_11905.1 |
| BPGM | huMAP3_04142.1 huMAP3_11712.1 huMAP3_11905.1 |
| PGAM1 | huMAP3_04142.1 huMAP3_11712.1 huMAP3_11905.1 |
| KLF16 | huMAP3_09685.1 huMAP3_11322.1 huMAP3_11712.1 huMAP3_11905.1 huMAP3_12785.1 |
| PGAM2 | huMAP3_04142.1 huMAP3_11712.1 huMAP3_11905.1 |