hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11909.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SMAD1 | Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) | 5 | UniProt NCBI |
| SMURF1 | E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1) | 5 | UniProt NCBI |
| SP110 | Sp110 nuclear body protein (Interferon-induced protein 41/75) (Speckled 110 kDa) (Transcriptional coactivator Sp110) | 5 | UniProt NCBI |
| SMURF2 | E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-201451 | 3.2237438451e-06 | 0.75 | SMAD1 SMURF2 SMURF1 | Signaling by BMP |
| KEGG:04350 | 3.62297031734e-05 | 0.75 | SMAD1 SMURF2 SMURF1 | TGF-beta signaling pathway |
| WP:WP1425 | 0.000114838123418 | 0.5 | SMAD1 SMURF1 | Bone morphogenic protein signaling and regulation |
| REAC:R-HSA-9006936 | 0.000284930280132 | 0.75 | SMAD1 SMURF2 SMURF1 | Signaling by TGFB family members |
| WP:WP4249 | 0.00169541860832 | 0.5 | SMURF1 SMURF2 | Hedgehog signaling pathway |
| KEGG:04340 | 0.00247340401034 | 0.5 | SMURF1 SMURF2 | Hedgehog signaling pathway |
| REAC:R-HSA-2173788 | 0.00258893271292 | 0.5 | SMURF1 SMURF2 | Downregulation of TGF-beta receptor signaling |
| REAC:R-HSA-2173789 | 0.00837722051003 | 0.5 | SMURF1 SMURF2 | TGF-beta receptor signaling activates SMADs |
| KEGG:04520 | 0.00909742323246 | 0.5 | SMURF1 SMURF2 | Adherens junction |
| GO:0046332 | 0.0106287970558 | 0.75 | SMAD1 SMURF2 SMURF1 | SMAD binding |
| KEGG:04137 | 0.0118173906169 | 0.5 | SMURF1 SMURF2 | Mitophagy - animal |
| REAC:R-HSA-8941858 | 0.0146019089592 | 0.5 | SMURF1 SMURF2 | Regulation of RUNX3 expression and activity |
| WP:WP366 | 0.0177395403747 | 0.5 | SMURF1 SMURF2 | TGF beta signaling pathway |
| REAC:R-HSA-4608870 | 0.0199119958937 | 0.5 | SMURF1 SMURF2 | Asymmetric localization of PCP proteins |
| KEGG:04120 | 0.0224124539322 | 0.5 | SMURF1 SMURF2 | Ubiquitin mediated proteolysis |
| REAC:R-HSA-5632684 | 0.0297941212351 | 0.5 | SMURF1 SMURF2 | Hedgehog 'on' state |
| REAC:R-HSA-170834 | 0.0380580405855 | 0.5 | SMURF1 SMURF2 | Signaling by TGF-beta Receptor Complex |
| REAC:R-HSA-8878159 | 0.0389395459224 | 0.5 | SMURF1 SMURF2 | Transcriptional regulation by RUNX3 |
| REAC:R-HSA-4086400 | 0.041644107744 | 0.5 | SMURF1 SMURF2 | PCP/CE pathway |
| GO:0030509 | 0.0434703685672 | 0.75 | SMAD1 SMURF2 SMURF1 | BMP signaling pathway |
| GO:0071773 | 0.048062454325 | 0.75 | SMAD1 SMURF2 SMURF1 | cellular response to BMP stimulus |
| GO:0071772 | 0.048062454325 | 0.75 | SMAD1 SMURF2 SMURF1 | response to BMP |
| CORUM:2642 | 0.049938562206 | 0.25 | SMAD1 | SMAD1-P300 complex |
| CORUM:2958 | 0.049938562206 | 0.25 | SMAD1 | SMAD1-CBP complex |
| CORUM:2992 | 0.049938562206 | 0.25 | SMURF2 | Ubiquitin E3 ligase (SMAD7, SMURF2) |
| CORUM:2996 | 0.049938562206 | 0.25 | SMURF1 | Ubiquitin E3 ligase (SMAD7, SMURF1) |
| CORUM:3972 | 0.049938562206 | 0.25 | SMURF2 | Ubiquitin E3 ligase (SMURF2, SMAD3) - SnoN complex, TGF(beta)-dependent |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SMURF2 | SMURF1 | 0.969 | 0.146 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| SMAD1 | SMURF2 | 0.966 | 0.156 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| SP110 | SMURF2 | 0.904 | bioplex3_WMM WMM_only | |
| SMAD1 | SMURF1 | 0.502 | 0.104 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| SMAD1 | huMAP3_03070.1 huMAP3_11909.1 huMAP3_13362.1 huMAP3_13748.1 huMAP3_14109.1 huMAP3_14587.1 |
| SMURF1 | huMAP3_03070.1 huMAP3_11909.1 huMAP3_14109.1 |
| SP110 | huMAP3_00713.1 huMAP3_06161.1 huMAP3_07782.1 huMAP3_11909.1 huMAP3_14109.1 |
| SMURF2 | huMAP3_03070.1 huMAP3_11909.1 huMAP3_14109.1 |