hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_11931.1

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
PIP4K2A	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha)	5	UniProt NCBI
PLCD3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3)	5	UniProt NCBI
TCOF1	Treacle protein (Treacher Collins syndrome protein)	5	UniProt NCBI
RTF1	RNA polymerase-associated protein RTF1 homolog	5	UniProt NCBI
PIP4K2C	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma)	5	UniProt NCBI
CWC22	Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) (fSAPb)	5	UniProt NCBI
CT45A7	Cancer/testis antigen family 45 member A7 (Cancer/testis antigen 45A7)	2	UniProt NCBI
AFF3	AF4/FMR2 family member 3 (Lymphoid nuclear protein related to AF4) (Protein LAF-4)	5	UniProt NCBI
NOLC1	Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130)	5	UniProt NCBI
NOS1AP	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C-terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein)	5	UniProt NCBI
CWC27	Spliceosome-associated protein CWC27 homolog (Antigen NY-CO-10) (Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog) (PPIase CWC27) (Serologically defined colon cancer antigen 10)	5	UniProt NCBI
NAF1	H/ACA ribonucleoprotein complex non-core subunit NAF1 (hNAF1)	5	UniProt NCBI
C1orf226	Uncharacterized protein C1orf226	2	UniProt NCBI
BRD2	Bromodomain-containing protein 2 (O27.1.1)	5	UniProt NCBI
SYT2	Synaptotagmin-2 (Synaptotagmin II) (SytII)	5	UniProt NCBI
PIP4K2B	Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta)	5	UniProt NCBI
PNISR	Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18)	5	UniProt NCBI
CAMKV	CaM kinase-like vesicle-associated protein	5	UniProt NCBI
DENND2D	DENN domain-containing protein 2D	3	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-8847453	2.22907374814e-06	0.157894736842	PIP4K2B PIP4K2A PIP4K2C	Synthesis of PIPs in the nucleus
WP:WP5411	2.77304132123e-05	0.210526315789	PLCD3 PIP4K2B PIP4K2A PIP4K2C	Phosphatidyl inositol phosphate pathway
WP:WP4971	2.77304132123e-05	0.210526315789	PLCD3 PIP4K2B PIP4K2A PIP4K2C	Phosphoinositides metabolism
REAC:R-HSA-6811555	4.66186500736e-05	0.157894736842	PIP4K2B PIP4K2A PIP4K2C	PI5P Regulates TP53 Acetylation
KEGG:00562	7.64517949147e-05	0.210526315789	PLCD3 PIP4K2B PIP4K2A PIP4K2C	Inositol phosphate metabolism
GO:1902633	9.31403198031e-05	0.157894736842	PIP4K2B PIP4K2A PIP4K2C	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process
GO:0016309	9.31403198031e-05	0.157894736842	PIP4K2B PIP4K2A PIP4K2C	1-phosphatidylinositol-5-phosphate 4-kinase activity
GO:1902635	9.31403198031e-05	0.157894736842	PIP4K2B PIP4K2A PIP4K2C	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
KEGG:04070	0.000224907703956	0.210526315789	PLCD3 PIP4K2B PIP4K2A PIP4K2C	Phosphatidylinositol signaling system
REAC:R-HSA-6804758	0.0022146928548	0.157894736842	PIP4K2B PIP4K2A PIP4K2C	Regulation of TP53 Activity through Acetylation
GO:0016308	0.00519447563198	0.157894736842	PIP4K2B PIP4K2A PIP4K2C	1-phosphatidylinositol-4-phosphate 5-kinase activity
HPA:0440342	0.00538083835981	0.684210526316	PNISR BRD2 PIP4K2A PLCD3 DENND2D AFF3 CWC27 RTF1 NAF1 C1orf226 CWC22 PIP4K2C TCOF1	skeletal muscle; myocytes[>=Medium]
REAC:R-HSA-1660499	0.00872245572183	0.157894736842	PIP4K2B PIP4K2A PIP4K2C	Synthesis of PIPs at the plasma membrane
HPA:0100131	0.0208473164472	0.842105263158	PNISR BRD2 PIP4K2A DENND2D CAMKV PLCD3 NOS1AP AFF3 CWC27 RTF1 NAF1 C1orf226 CWC22 NOLC1 PIP4K2C TCOF1	cerebral cortex; neuronal cells[>=Low]
REAC:R-HSA-1483255	0.0314296506547	0.157894736842	PIP4K2B PIP4K2A PIP4K2C	PI Metabolism
REAC:R-HSA-6811558	0.0341054798604	0.157894736842	PIP4K2B PIP4K2A PIP4K2C	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
HPA:0100000	0.0360810900903	0.894736842105	PNISR BRD2 PIP4K2A DENND2D CAMKV PLCD3 NOS1AP AFF3 CWC27 RTF1 NAF1 C1orf226 CWC22 NOLC1 SYT2 PIP4K2C TCOF1	cerebral cortex
REAC:R-HSA-199418	0.0446315191459	0.157894736842	PIP4K2B PIP4K2A PIP4K2C	Negative regulation of the PI3K/AKT network

Edges

Protein 1	Protein 2	Score	ProteomeHD
PIP4K2B	PIP4K2C	1.0	0.014
PIP4K2A	PIP4K2C	1.0	0.0883043478261
PIP4K2A	PIP4K2B	1.0	0.318
PIP4K2A	PLCD3	0.999	0.068
PIP4K2A	NOLC1	0.998
PIP4K2A	NOS1AP	0.997	0.074
PIP4K2C	NOLC1	0.996
PLCD3	PIP4K2C	0.994	0.15
CWC22	SYT2	0.994
TCOF1	PIP4K2C	0.991	0.056
PIP4K2A	PNISR	0.99	0.024
CWC22	NOLC1	0.986
PIP4K2A	TCOF1	0.984	0.11
PIP4K2C	NOS1AP	0.982	0.098
DENND2D	NOLC1	0.982
PIP4K2A	BRD2	0.975	0.012
TCOF1	DENND2D	0.975	0.094
NOS1AP	C1orf226	0.973	0.166
PIP4K2A	RTF1	0.973	0.114
RTF1	DENND2D	0.972	0.06
PIP4K2A	NAF1	0.972	0.06
PIP4K2B	NOS1AP	0.971	0.042
PIP4K2A	AFF3	0.963
NOLC1	SYT2	0.962
TCOF1	CAMKV	0.962	0.07
CAMKV	BRD2	0.962	0.054
CWC22	NAF1	0.961	0.292
CWC22	CWC27	0.96	0.316
CWC27	SYT2	0.959
AFF3	SYT2	0.954
PIP4K2A	C1orf226	0.952	0.104
CAMKV	NAF1	0.951	0.05
PIP4K2B	PLCD3	0.95	0.068
TCOF1	NOLC1	0.95
PLCD3	NOS1AP	0.948	0.18
CWC22	CAMKV	0.946	0.088
PNISR	CAMKV	0.94	0.06
CWC22	PLCD3	0.936	0.07
PLCD3	BRD2	0.934	0.074
PLCD3	NAF1	0.93	0.054
NOLC1	CAMKV	0.925
CWC22	PIP4K2A	0.925	0.064
PLCD3	TCOF1	0.908	0.028
NOS1AP	NAF1	0.906	0.154
PLCD3	PNISR	0.902	0.066
PLCD3	NOLC1	0.875
CWC22	BRD2	0.875	0.148
PIP4K2C	CAMKV	0.867	0.072
CWC27	NAF1	0.848	0.112
PLCD3	RTF1	0.83	0.064
NOLC1	CWC27	0.82
CT45A7	NAF1	0.819	0.054
RTF1	BRD2	0.812	0.134
PIP4K2C	RTF1	0.809	0.024
SYT2	NAF1	0.806
PNISR	BRD2	0.798	0.194
C1orf226	NAF1	0.76	0.08
NOLC1	NAF1	0.759
PLCD3	CWC27	0.728	0.11
CWC22	PNISR	0.657	0.246
CT45A7	NOS1AP	0.652	0.078
CWC22	CT45A7	0.647	0.068
NOLC1	BRD2	0.642
CWC22	RTF1	0.578	0.114
BRD2	NAF1	0.556	0.06
TCOF1	RTF1	0.544	0.118
RTF1	NOLC1	0.527
PNISR	NAF1	0.527	0.1
TCOF1	BRD2	0.504	0.176
CWC22	DENND2D	0.503	0.082
RTF1	SYT2	0.484
PIP4K2A	CWC27	0.481	0.0542352941176
CAMKV	NOS1AP	0.471	0.148
CWC27	BRD2	0.412	0.182
TCOF1	PNISR	0.4	0.204
CT45A7	BRD2	0.384	0.094
PNISR	CWC27	0.356	0.166
RTF1	NAF1	0.341	0.08
NOLC1	NOS1AP	0.32
CWC22	NOS1AP	0.306	0.074
TCOF1	NOS1AP	0.304	0.084
TCOF1	SYT2	0.293
CAMKV	SYT2	0.281
NOS1AP	BRD2	0.277	0.066
RTF1	AFF3	0.262
PIP4K2B	TCOF1	0.26	0.044
NOLC1	CT45A7	0.258
PIP4K2C	BRD2	0.256	0.032
DENND2D	BRD2	0.245	0.07
PNISR	NOLC1	0.243
PIP4K2B	AFF3	0.213
PLCD3	C1orf226	0.211	0.072
CWC22	PIP4K2C	0.207	0.046
PIP4K2B	BRD2	0.199	0.03
PLCD3	AFF3	0.193
PNISR	C1orf226	0.189	0.108
PIP4K2C	C1orf226	0.188	0.072
RTF1	CWC27	0.18	0.176
PIP4K2B	NOLC1	0.178
PNISR	AFF3	0.172
TCOF1	AFF3	0.17
PNISR	NOS1AP	0.167	0.114
CWC22	C1orf226	0.166	0.072
AFF3	BRD2	0.165
AFF3	NAF1	0.165
AFF3	C1orf226	0.164
CWC27	NOS1AP	0.161	0.05
CWC22	AFF3	0.159
NOLC1	AFF3	0.155
PIP4K2C	CT45A7	0.154	0.088
PLCD3	CAMKV	0.15	0.136
RTF1	NOS1AP	0.145	0.076
AFF3	NOS1AP	0.14
RTF1	C1orf226	0.139	0.098
PIP4K2B	NAF1	0.139	0.048
TCOF1	CT45A7	0.137	0.074
CT45A7	CWC27	0.136	0.112
PIP4K2C	AFF3	0.134
PIP4K2B	C1orf226	0.131	0.078
PIP4K2B	CAMKV	0.124	0.088
TCOF1	NAF1	0.124	0.11
C1orf226	BRD2	0.122	0.118
CWC27	AFF3	0.12
TCOF1	C1orf226	0.117	0.056
RTF1	PNISR	0.107	0.254
NOLC1	C1orf226	0.106
CAMKV	AFF3	0.102
PIP4K2C	CWC27	0.096	0.024
CWC22	TCOF1	0.09	0.182
CAMKV	CWC27	0.089	0.118
PIP4K2B	PNISR	0.082	0.022
PIP4K2A	CAMKV	0.082	0.038
PIP4K2C	NAF1	0.078	0.074
PIP4K2C	PNISR	0.075	0.054
RTF1	CAMKV	0.069	0.054
TCOF1	CWC27	0.058	0.202
CAMKV	C1orf226	0.054	0.06
CWC22	PIP4K2B	0.052	0.02
PIP4K2C	SYT2	0.051
PIP4K2B	RTF1	0.05	0.03
CWC27	C1orf226	0.039	0.084
PIP4K2B	SYT2	0.034
PIP4K2B	CWC27	0.028	0.022
PIP4K2A	SYT2	0.021
DENND2D	CWC27	0.002	0.098

Related Complexes

Genename	Complexes
PIP4K2A	huMAP3_00550.1 huMAP3_00708.1 huMAP3_02291.1 huMAP3_02922.1 huMAP3_03481.1 huMAP3_05647.1 huMAP3_06847.1 huMAP3_07416.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08874.1 huMAP3_08914.1 huMAP3_09163.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10366.1 huMAP3_10611.1 huMAP3_10883.1 huMAP3_10957.1 huMAP3_11931.1 huMAP3_12214.1 huMAP3_12350.1 huMAP3_13786.1 huMAP3_13857.1 huMAP3_14693.1
PLCD3	huMAP3_00550.1 huMAP3_02291.1 huMAP3_03481.1 huMAP3_04301.1 huMAP3_06847.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08739.1 huMAP3_08874.1 huMAP3_09163.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10366.1 huMAP3_10611.1 huMAP3_10753.1 huMAP3_10957.1 huMAP3_11931.1 huMAP3_12214.1 huMAP3_12350.1
TCOF1	huMAP3_01275.1 huMAP3_03799.1 huMAP3_06847.1 huMAP3_07286.1 huMAP3_09163.1 huMAP3_09447.1 huMAP3_09823.1 huMAP3_10819.1 huMAP3_10957.1 huMAP3_11931.1 huMAP3_13072.1
RTF1	huMAP3_01560.1 huMAP3_02252.1 huMAP3_03481.1 huMAP3_07042.1 huMAP3_07445.1 huMAP3_08327.1 huMAP3_08432.1 huMAP3_08925.1 huMAP3_09657.1 huMAP3_10957.1 huMAP3_11030.1 huMAP3_11931.1 huMAP3_12214.1 huMAP3_12350.1 huMAP3_13857.1
PIP4K2C	huMAP3_01275.1 huMAP3_04301.1 huMAP3_05601.1 huMAP3_05855.1 huMAP3_07416.1 huMAP3_07859.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08874.1 huMAP3_08914.1 huMAP3_09163.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10366.1 huMAP3_10611.1 huMAP3_10753.1 huMAP3_10883.1 huMAP3_10957.1 huMAP3_11931.1 huMAP3_12214.1 huMAP3_12350.1 huMAP3_13786.1 huMAP3_13857.1
CWC22	huMAP3_00373.1 huMAP3_00489.1 huMAP3_07467.1 huMAP3_08365.1 huMAP3_08647.1 huMAP3_09637.1 huMAP3_09803.1 huMAP3_09943.1 huMAP3_10250.1 huMAP3_11077.1 huMAP3_11931.1 huMAP3_12350.1
CT45A7	huMAP3_02666.1 huMAP3_11192.1 huMAP3_11931.1 huMAP3_13486.1 huMAP3_13653.1 huMAP3_14303.1
AFF3	huMAP3_02922.1 huMAP3_03741.1 huMAP3_08199.1 huMAP3_08432.1 huMAP3_08616.1 huMAP3_08874.1 huMAP3_09163.1 huMAP3_09823.1 huMAP3_11931.1 huMAP3_12214.1 huMAP3_12350.1 huMAP3_12618.1 huMAP3_13608.1 huMAP3_13857.1 huMAP3_13924.1 huMAP3_14008.1 huMAP3_14061.1 huMAP3_14693.1
NOLC1	huMAP3_02291.1 huMAP3_08914.1 huMAP3_09943.1 huMAP3_10250.1 huMAP3_10611.1 huMAP3_11931.1 huMAP3_13072.1 huMAP3_15090.1
NOS1AP	huMAP3_03481.1 huMAP3_04394.1 huMAP3_06573.1 huMAP3_06847.1 huMAP3_06938.1 huMAP3_07124.1 huMAP3_08199.1 huMAP3_08432.1 huMAP3_08493.1 huMAP3_08874.1 huMAP3_08914.1 huMAP3_09163.1 huMAP3_09303.1 huMAP3_09607.1 huMAP3_09823.1 huMAP3_10250.1 huMAP3_10469.1 huMAP3_10611.1 huMAP3_10753.1 huMAP3_10883.1 huMAP3_10957.1 huMAP3_11931.1 huMAP3_12350.1 huMAP3_13786.1
CWC27	huMAP3_02785.1 huMAP3_04281.1 huMAP3_07467.1 huMAP3_08647.1 huMAP3_09803.1 huMAP3_11077.1 huMAP3_11931.1 huMAP3_12350.1 huMAP3_13924.1
NAF1	huMAP3_06091.1 huMAP3_07467.1 huMAP3_08647.1 huMAP3_09803.1 huMAP3_09840.1 huMAP3_09943.1 huMAP3_10250.1 huMAP3_10644.1 huMAP3_11077.1 huMAP3_11931.1 huMAP3_12350.1 huMAP3_12813.1 huMAP3_13386.1
C1orf226	huMAP3_03481.1 huMAP3_04394.1 huMAP3_06573.1 huMAP3_06847.1 huMAP3_07124.1 huMAP3_08432.1 huMAP3_08715.1 huMAP3_08914.1 huMAP3_09163.1 huMAP3_09303.1 huMAP3_09520.1 huMAP3_09607.1 huMAP3_10250.1 huMAP3_10469.1 huMAP3_10611.1 huMAP3_10883.1 huMAP3_10957.1 huMAP3_11931.1 huMAP3_12350.1 huMAP3_13786.1
BRD2	huMAP3_05111.1 huMAP3_05474.1 huMAP3_07000.1 huMAP3_07888.1 huMAP3_09038.1 huMAP3_09097.1 huMAP3_10856.1 huMAP3_11931.1 huMAP3_12214.1 huMAP3_12310.1
SYT2	huMAP3_03741.1 huMAP3_04559.1 huMAP3_06750.1 huMAP3_06950.1 huMAP3_08616.1 huMAP3_10757.1 huMAP3_11931.1 huMAP3_12618.1 huMAP3_13063.1 huMAP3_13924.1 huMAP3_14008.1 huMAP3_14061.1
PIP4K2B	huMAP3_00550.1 huMAP3_00708.1 huMAP3_02291.1 huMAP3_03481.1 huMAP3_04301.1 huMAP3_06847.1 huMAP3_07416.1 huMAP3_07859.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08874.1 huMAP3_08914.1 huMAP3_09163.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10366.1 huMAP3_10611.1 huMAP3_10753.1 huMAP3_10883.1 huMAP3_10957.1 huMAP3_11931.1 huMAP3_12214.1 huMAP3_12350.1 huMAP3_13786.1 huMAP3_13857.1
PNISR	huMAP3_02291.1 huMAP3_02922.1 huMAP3_03481.1 huMAP3_05647.1 huMAP3_06847.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08874.1 huMAP3_08914.1 huMAP3_09163.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10611.1 huMAP3_10957.1 huMAP3_11931.1 huMAP3_12028.1 huMAP3_12214.1 huMAP3_12350.1 huMAP3_13857.1 huMAP3_13971.1
CAMKV	huMAP3_02548.1 huMAP3_03453.1 huMAP3_06372.1 huMAP3_10158.1 huMAP3_10312.1 huMAP3_11931.1 huMAP3_12350.1 huMAP3_13971.1
DENND2D	huMAP3_02252.1 huMAP3_07042.1 huMAP3_07445.1 huMAP3_08432.1 huMAP3_09657.1 huMAP3_11030.1 huMAP3_11931.1 huMAP3_12350.1 huMAP3_13890.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_11931.1