hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11938.1
Complex Portal: CPX-16014
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RIPOR1 | Rho family-interacting cell polarization regulator 1 | 5 | UniProt NCBI |
| C4orf19 | Uncharacterized protein C4orf19 | 2 | UniProt NCBI |
| STK25 | Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1) | 5 | UniProt NCBI |
| SLC25A43 | Solute carrier family 25 member 43 | 3 | UniProt NCBI |
| STK26 | Serine/threonine-protein kinase 26 (EC 2.7.11.1) (MST3 and SOK1-related kinase) (Mammalian STE20-like protein kinase 4) (MST-4) (STE20-like kinase MST4) (Serine/threonine-protein kinase MASK) | 5 | UniProt NCBI |
| STK24 | Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)] | 5 | UniProt NCBI |
| TAOK1 | Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC-B) (MARK Kinase) (MARKK) (Prostate-derived sterile 20-like kinase 2) (PSK-2) (PSK2) (Prostate-derived STE20-like kinase 2) (Thousand and one amino acid protein kinase 1) (TAOK1) (hTAOK1) | 5 | UniProt NCBI |
| PROSER2 | Proline and serine-rich protein 2 | 3 | UniProt NCBI |
| PDCD10 | Programmed cell death protein 10 (Cerebral cavernous malformations 3 protein) (TF-1 cell apoptosis-related protein 15) | 5 | UniProt NCBI |
| CAB39 | Calcium-binding protein 39 (MO25alpha) (Protein Mo25) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0051683 | 0.000644767051209 | 0.3 | STK25 RIPOR1 PDCD10 | establishment of Golgi localization |
| GO:0031098 | 0.000740310437941 | 0.4 | STK25 PDCD10 STK26 TAOK1 | stress-activated protein kinase signaling cascade |
| GO:0051645 | 0.00252937426606 | 0.3 | STK25 RIPOR1 PDCD10 | Golgi localization |
| GO:0032874 | 0.00328700479383 | 0.3 | STK25 PDCD10 TAOK1 | positive regulation of stress-activated MAPK cascade |
| GO:0070304 | 0.00522556754165 | 0.3 | STK25 PDCD10 TAOK1 | positive regulation of stress-activated protein kinase signaling cascade |
| GO:0000302 | 0.028615496869 | 0.4 | STK25 PDCD10 STK26 STK24 | response to reactive oxygen species |
| GO:0032872 | 0.033448305627 | 0.3 | STK25 PDCD10 TAOK1 | regulation of stress-activated MAPK cascade |
| GO:0070302 | 0.0463773280544 | 0.3 | STK25 PDCD10 TAOK1 | regulation of stress-activated protein kinase signaling cascade |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| STK25 | PDCD10 | 1.0 | 0.19 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 fraction | |
| STK26 | PDCD10 | 1.0 | 0.784 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 fraction | |
| STK24 | PDCD10 | 1.0 | 0.19 |
mutually_exclusive (P62714)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 fraction |
| STK25 | PROSER2 | 1.0 | 0.092 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| STK24 | PROSER2 | 1.0 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| C4orf19 | STK25 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| PROSER2 | PDCD10 | 0.999 | 0.112 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| STK26 | PROSER2 | 0.999 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| STK25 | STK26 | 0.999 | 0.122 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| STK25 | STK24 | 0.999 | 0.478 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| STK26 | STK24 | 0.998 | 0.116 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| C4orf19 | PDCD10 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| C4orf19 | STK24 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| C4orf19 | STK26 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| STK25 | TAOK1 | 0.993 | 0.124 |
mutually_exclusive (Q9P289)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| CAB39 | STK25 | 0.988 | 0.196 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SLC25A43 | PROSER2 | 0.975 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TAOK1 | PDCD10 | 0.972 | 0.142 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CAB39 | PDCD10 | 0.958 | 0.184 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| RIPOR1 | STK25 | 0.936 | 0.088 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| STK26 | TAOK1 | 0.897 | 0.102 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM WMM_only |
| STK24 | TAOK1 | 0.893 | 0.09 |
mutually_exclusive (Q9P289)
|
bioplex_WMM bioplex3_WMM WMM_only |
| CAB39 | STK24 | 0.808 | 0.252 | bioplex_WMM bioplex3_WMM WMM_only | |
| RIPOR1 | PDCD10 | 0.767 | 0.028 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| CAB39 | STK26 | 0.756 | 0.104 | bioplex_WMM bioplex3_WMM WMM_only | |
| TAOK1 | PROSER2 | 0.343 | 0.117263157895 | bioplex3_WMM WMM_only | |
| CAB39 | TAOK1 | 0.216 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only | |
| RIPOR1 | STK24 | 0.214 | 0.066 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| RIPOR1 | STK26 | 0.104 | 0.028 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| SLC25A43 | STK25 | 0.01 | bioplex3_HEK293 bioplex () | ||
| SLC25A43 | PDCD10 | 0.01 | bioplex3_HEK293 bioplex () |
Related Complexes