hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11939.1
Complex Portal: CPX-20391
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| BTBD7 | BTB/POZ domain-containing protein 7 | 4 | UniProt NCBI |
| UBA1 | Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) | 5 | UniProt NCBI |
| DOC2A | Double C2-like domain-containing protein alpha (Doc2) (Doc2-alpha) | 5 | UniProt NCBI |
| KCTD21 | BTB/POZ domain-containing protein KCTD21 (KCASH2 protein) (Potassium channel tetramerization domain-containing protein 21) | 5 | UniProt NCBI |
| UBASH3B | Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2) | 5 | UniProt NCBI |
| MSRA | Mitochondrial peptide methionine sulfoxide reductase (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase) (Peptide Met(O) reductase) (Protein-methionine-S-oxide reductase) (PMSR) | 5 | UniProt NCBI |
| RPH3A | Rabphilin-3A (Exophilin-1) | 5 | UniProt NCBI |
| TTC21B | Tetratricopeptide repeat protein 21B (TPR repeat protein 21B) (Intraflagellar transport 139 homolog) | 5 | UniProt NCBI |
| DOC2B | Double C2-like domain-containing protein beta (Doc2-beta) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0061669 | 0.00010757157937 | 0.375 | DOC2B DOC2A RPH3A | spontaneous neurotransmitter secretion |
| GO:0098814 | 0.000644767051209 | 0.375 | DOC2B DOC2A RPH3A | spontaneous synaptic transmission |
| GO:0017158 | 0.00824905178996 | 0.375 | DOC2B DOC2A RPH3A | regulation of calcium ion-dependent exocytosis |
| GO:0098850 | 0.0131096201623 | 0.25 | DOC2A RPH3A | extrinsic component of synaptic vesicle membrane |
| GO:0017156 | 0.0349415747767 | 0.375 | DOC2B DOC2A RPH3A | calcium-ion regulated exocytosis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DOC2A | DOC2B | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DOC2A | KCTD21 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| RPH3A | DOC2B | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| DOC2A | UBASH3B | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| MSRA | UBASH3B | 0.987 | 0.058 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| DOC2A | TTC21B | 0.977 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DOC2B | TTC21B | 0.961 |
structurally_consistent (Q14183)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| DOC2B | UBASH3B | 0.932 | bioplex_WMM bioplex3_WMM WMM_only | ||
| DOC2B | KCTD21 | 0.921 | bioplex_WMM bioplex3_WMM WMM_only | ||
| BTBD7 | KCTD21 | 0.892 | bioplex3_WMM WMM_only | ||
| UBASH3B | KCTD21 | 0.886 | 0.096 | bioplex_WMM bioplex3_WMM WMM_only | |
| TTC21B | KCTD21 | 0.855 | 0.112 | bioplex_WMM bioplex3_WMM WMM_only | |
| UBASH3B | TTC21B | 0.855 | 0.122 | bioplex_WMM bioplex3_WMM WMM_only | |
| TTC21B | UBA1 | 0.846 | 0.094 | boldt boldt_WMM WMM_only | |
| DOC2A | RPH3A | 0.078 | bioplex3_WMM WMM_only | ||
| DOC2B | UBA1 | 0.006 | bioplex3_HEK293 WMM_only | ||
| RPH3A | UBA1 | 0.005 | bioplex3_HEK293 bioplex () | ||
| MSRA | UBA1 | 0.001 | 0.165333333333 | bioplex3_HEK293 bioplex3_HCT116 WMM_only | |
| DOC2A | UBA1 | 0.001 | bioplex3_HEK293 bioplex () bioplex3_HCT116 |
Related Complexes