hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11970.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EIF2S1 | Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha) | 5 | UniProt NCBI |
| EIF1AY | Eukaryotic translation initiation factor 1A, Y-chromosomal (eIF-1A Y isoform) (eIF1A Y isoform) (Eukaryotic translation initiation factor 4C) (eIF-4C) | 4 | UniProt NCBI |
| EIF1AX | Eukaryotic translation initiation factor 1A, X-chromosomal (eIF-1A X isoform) (eIF1A X isoform) (Eukaryotic translation initiation factor 4C) (eIF-4C) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP107 | 1.42815777161e-06 | 1.0 | EIF1AX EIF2S1 EIF1AY | Translation factors |
| WP:WP5027 | 0.000118867546443 | 0.666666666667 | EIF2S1 EIF1AX | nsp1 from SARS CoV 2 inhibits translation initiation in the host cell |
| GO:0003743 | 0.00127301382402 | 1.0 | EIF1AX EIF2S1 EIF1AY | translation initiation factor activity |
| GO:0033290 | 0.00140460216025 | 0.666666666667 | EIF2S1 EIF1AX | eukaryotic 48S preinitiation complex |
| GO:0008135 | 0.00526161104852 | 1.0 | EIF1AX EIF2S1 EIF1AY | translation factor activity, RNA binding |
| REAC:R-HSA-72695 | 0.00902065028483 | 0.666666666667 | EIF2S1 EIF1AX | Formation of the ternary complex, and subsequently, the 43S complex |
| GO:0090079 | 0.00949377645712 | 1.0 | EIF1AX EIF2S1 EIF1AY | translation regulator activity, nucleic acid binding |
| REAC:R-HSA-72702 | 0.0116360425406 | 0.666666666667 | EIF2S1 EIF1AX | Ribosomal scanning and start codon recognition |
| REAC:R-HSA-72649 | 0.0116360425406 | 0.666666666667 | EIF2S1 EIF1AX | Translation initiation complex formation |
| REAC:R-HSA-72662 | 0.0120367347963 | 0.666666666667 | EIF2S1 EIF1AX | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| GO:0070993 | 0.0140440992017 | 0.666666666667 | EIF2S1 EIF1AX | translation preinitiation complex |
| GO:0006413 | 0.0180186629002 | 1.0 | EIF1AX EIF2S1 EIF1AY | translational initiation |
| GO:0045182 | 0.0207446272651 | 1.0 | EIF1AX EIF2S1 EIF1AY | translation regulator activity |
| REAC:R-HSA-156827 | 0.0406752460979 | 0.666666666667 | EIF2S1 EIF1AX | L13a-mediated translational silencing of Ceruloplasmin expression |
| REAC:R-HSA-72706 | 0.041419681818 | 0.666666666667 | EIF2S1 EIF1AX | GTP hydrolysis and joining of the 60S ribosomal subunit |
| REAC:R-HSA-72613 | 0.0468187221283 | 0.666666666667 | EIF2S1 EIF1AX | Eukaryotic Translation Initiation |
| REAC:R-HSA-72737 | 0.0468187221283 | 0.666666666667 | EIF2S1 EIF1AX | Cap-dependent Translation Initiation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| EIF1AY | EIF1AX | 0.96 | 0.08 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| EIF1AX | EIF2S1 | 0.944 | 0.6 | hein_WMM bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| EIF1AY | EIF2S1 | 0.085 | 0.074 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
Related Complexes