hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11987.1
Complex Portal: CPX-22730
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CCNI2 | Cyclin-I2 | 3 | UniProt NCBI |
| CCNI | Cyclin-I | 4 | UniProt NCBI |
| C2CD5 | C2 domain-containing protein 5 (C2 domain-containing phosphoprotein of 138 kDa) | 5 | UniProt NCBI |
| FIBP | Acidic fibroblast growth factor intracellular-binding protein (aFGF intracellular-binding protein) (FGF-1 intracellular-binding protein) | 5 | UniProt NCBI |
| CABLES1 | CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1) | 5 | UniProt NCBI |
| CDK5 | Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) | 5 | UniProt NCBI |
| CABLES2 | CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2) | 3 | UniProt NCBI |
| CNPPD1 | Protein CNPPD1 (Cyclin Pas1/PHO80 domain-containing protein 1) | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000307 | 0.00062119716087 | 0.5 | CNPPD1 CCNI2 CCNI CDK5 | cyclin-dependent protein kinase holoenzyme complex |
| REAC:R-HSA-983231 | 0.0139290924108 | 0.375 | CABLES1 CDK5 CABLES2 | Factors involved in megakaryocyte development and platelet production |
| GO:1902554 | 0.0179481315058 | 0.5 | CNPPD1 CCNI2 CCNI CDK5 | serine/threonine protein kinase complex |
| GO:1902911 | 0.0298370680549 | 0.5 | CNPPD1 CCNI2 CCNI CDK5 | protein kinase complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| C2CD5 | FIBP | 1.0 | 0.62 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| FIBP | CABLES1 | 1.0 | 0.118 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| FIBP | CABLES2 | 0.999 | 0.146 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| FIBP | CDK5 | 0.999 | 0.056 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| C2CD5 | CDK5 | 0.995 | 0.11 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| CDK5 | CCNI | 0.993 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| C2CD5 | CABLES1 | 0.992 | 0.084 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| CNPPD1 | CDK5 | 0.992 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CABLES1 | CDK5 | 0.987 | 0.086 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| C2CD5 | CABLES2 | 0.923 | 0.07 | bioplex_WMM bioplex3_WMM WMM_only | |
| CABLES1 | CABLES2 | 0.899 | 0.058 | bioplex_WMM bioplex3_WMM WMM_only | |
| CDK5 | CCNI2 | 0.897 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CABLES2 | CDK5 | 0.805 | 0.078 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes