hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11988.1
Complex Portal: CPX-23683
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ZCCHC10 | Zinc finger CCHC domain-containing protein 10 | 5 | UniProt NCBI |
| DOT1L | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | 5 | UniProt NCBI |
| DZIP1 | Cilium assembly protein DZIP1 (DAZ-interacting protein 1/2) (DAZ-interacting zinc finger protein 1) | 5 | UniProt NCBI |
| SETDB2 | Histone-lysine N-methyltransferase SETDB2 (EC 2.1.1.366) (Chronic lymphocytic leukemia deletion region gene 8 protein) (Lysine N-methyltransferase 1F) (SET domain bifurcated 2) | 5 | UniProt NCBI |
| SENP7 | Sentrin-specific protease 7 (EC 3.4.22.-) (SUMO-1-specific protease 2) (Sentrin/SUMO-specific protease SENP7) | 5 | UniProt NCBI |
| CIBAR1 | CBY1-interacting BAR domain-containing protein 1 | 5 | UniProt NCBI |
| CCN1 | CCN family member 1 (Cellular communication network factor 1) (Cysteine-rich angiogenic inducer 61) (Insulin-like growth factor-binding protein 10) (IBP-10) (IGF-binding protein 10) (IGFBP-10) (Protein CYR61) (Protein GIG1) | 5 | UniProt NCBI |
| PTPN13 | Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00310 | 0.0211290680368 | 0.25 | DOT1L SETDB2 | Lysine degradation |
| WP:WP2369 | 0.044500386952 | 0.25 | DOT1L SETDB2 | Histone modifications |
| CORUM:6524 | 0.0499436884912 | 0.125 | DZIP1 | DZIP1-GLI3 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PTPN13 | ZCCHC10 | 0.995 | 0.116 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| SETDB2 | SENP7 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ZCCHC10 | SETDB2 | 0.984 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ZCCHC10 | DZIP1 | 0.981 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ZCCHC10 | SENP7 | 0.97 | 0.104 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ZCCHC10 | CIBAR1 | 0.935 | 0.092 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| DOT1L | SETDB2 | 0.923 | bioplex3_WMM WMM_only | ||
| DOT1L | SENP7 | 0.905 | 0.084 | bioplex3_WMM WMM_only | |
| ZCCHC10 | CCN1 | 0.905 | 0.07 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| DZIP1 | CIBAR1 | 0.539 | bioplex3_WMM WMM_only boldt_WMM | ||
| SETDB2 | CCN1 | 0.274 | bioplex3_WMM WMM_only | ||
| SENP7 | CCN1 | 0.21 | 0.054 | bioplex3_WMM WMM_only | |
| DZIP1 | SETDB2 | 0.113 | bioplex3_WMM WMM_only | ||
| DZIP1 | SENP7 | 0.095 | bioplex3_WMM WMM_only | ||
| DZIP1 | CCN1 | 0.095 | bioplex3_WMM WMM_only | ||
| SETDB2 | CIBAR1 | 0.076 | bioplex3_WMM WMM_only | ||
| PTPN13 | CCN1 | 0.076 | 0.15 | bioplex3_WMM WMM_only | |
| CCN1 | CIBAR1 | 0.076 | 0.066 | bioplex3_WMM WMM_only | |
| SENP7 | CIBAR1 | 0.076 | 0.062 | bioplex3_WMM WMM_only | |
| PTPN13 | SETDB2 | 0.076 | bioplex3_WMM WMM_only | ||
| PTPN13 | SENP7 | 0.076 | 0.132 | bioplex3_WMM WMM_only | |
| PTPN13 | CIBAR1 | 0.061 | 0.084 | bioplex3_WMM WMM_only | |
| PTPN13 | DZIP1 | 0.04 | bioplex3_WMM youn_WMM WMM_only | ||
| PTPN13 | DOT1L | 0.005 | 0.126 | youn_WMM WMM_only |
Related Complexes