hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11989.1
Complex Portal: CPX-18020
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HES1 | Transcription factor HES-1 (Class B basic helix-loop-helix protein 39) (bHLHb39) (Hairy and enhancer of split 1) (Hairy homolog) (Hairy-like protein) (hHL) | 5 | UniProt NCBI |
| FBXL14 | F-box/LRR-repeat protein 14 (F-box and leucine-rich repeat protein 14) | 5 | UniProt NCBI |
| HES4 | Transcription factor HES-4 (hHES4) (Class B basic helix-loop-helix protein 42) (bHLHb42) (Hairy and enhancer of split 4) (bHLH factor Hes4) | 4 | UniProt NCBI |
| TLE1 | Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1) | 5 | UniProt NCBI |
| TBX1 | T-box transcription factor TBX1 (T-box protein 1) (Testis-specific T-box protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4844 | 0.00254884296025 | 0.4 | HES1 TLE1 | Influence of laminopathies on Wnt signaling |
| KEGG:04330 | 0.00509527283003 | 0.4 | HES1 TLE1 | Notch signaling pathway |
| WP:WP61 | 0.00553237697975 | 0.4 | HES1 TLE1 | Notch signaling pathway |
| WP:WP4879 | 0.00631928190743 | 0.4 | HES1 TLE1 | Overlap between signal transduction pathways contributing to LMNA laminopathies |
| REAC:R-HSA-2122947 | 0.0117954816348 | 0.4 | HES1 TLE1 | NOTCH1 Intracellular Domain Regulates Transcription |
| REAC:R-HSA-1980143 | 0.0258071378099 | 0.4 | HES1 TLE1 | Signaling by NOTCH1 |
| WP:WP4657 | 0.0287269200827 | 0.4 | HES1 TBX1 | 22q11 2 copy number variation syndrome |
| CORUM:3120 | 0.0498708842806 | 0.2 | TLE1 | OCT1-OBF1-DNA-TLE1 complex |
| CORUM:3125 | 0.0498708842806 | 0.2 | TLE1 | TLE1 homodimer complex |
| CORUM:3127 | 0.0498708842806 | 0.2 | TLE1 | TLE-Histone H3 complex |
| CORUM:3164 | 0.0498708842806 | 0.2 | TLE1 | HESX1-TLE1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TLE1 | HES1 | 0.997 | 0.108 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TLE1 | FBXL14 | 0.996 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| FBXL14 | HES1 | 0.946 | bioplex3_WMM WMM_only | ||
| TLE1 | HES4 | 0.891 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| TLE1 | TBX1 | 0.873 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| HES4 | TBX1 | 0.415 | bioplex3_WMM WMM_only | ||
| HES1 | HES4 | 0.415 | bioplex3_WMM WMM_only | ||
| HES1 | TBX1 | 0.415 | bioplex3_WMM WMM_only | ||
| FBXL14 | HES4 | 0.415 | bioplex3_WMM WMM_only | ||
| FBXL14 | TBX1 | 0.415 | bioplex3_WMM WMM_only |
Related Complexes