hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_12000.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PITX1 | Pituitary homeobox 1 (Hindlimb-expressed homeobox protein backfoot) (Homeobox protein PITX1) (Paired-like homeodomain transcription factor 1) | 5 | UniProt NCBI |
| HOXA5 | Homeobox protein Hox-A5 (Homeobox protein Hox-1C) | 5 | UniProt NCBI |
| ZBTB38 | Zinc finger and BTB domain-containing protein 38 | 5 | UniProt NCBI |
| SIRT1 | NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2592 | 0.0249718442456 | 0.25 | SIRT1 | SIRT1 homotrimer complex |
| CORUM:2593 | 0.049938562206 | 0.25 | SIRT1 | FOXO3-SIRT1 complex, oxidative stress stimulated |
| CORUM:2821 | 0.049938562206 | 0.25 | SIRT1 | hSIR2-p53 complex |
| CORUM:6846 | 0.049938562206 | 0.25 | SIRT1 | DBC1-SIRT1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ZBTB38 | SIRT1 | 0.998 | 0.191663932584 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| SIRT1 | HOXA5 | 0.927 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| SIRT1 | PITX1 | 0.899 | 0.219333333333 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| PITX1 | HOXA5 | 0.081 | bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| PITX1 | huMAP3_12000.1 huMAP3_13428.1 huMAP3_13742.1 huMAP3_14337.1 huMAP3_15021.1 |
| HOXA5 | huMAP3_12000.1 |
| ZBTB38 | huMAP3_01084.1 huMAP3_12000.1 huMAP3_13769.1 |
| SIRT1 | huMAP3_01084.1 huMAP3_12000.1 |