hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12009.1
Complex Portal: CPX-17387
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MTERF2 | Transcription termination factor 2, mitochondrial (Mitochondrial transcription termination factor 2) (mTERF2) (Mitochondrial transcription termination factor-like protein) (mTERF-like) (mTERFL) (mTERF domain-containing protein 3, mitochondrial) | 5 | UniProt NCBI |
| ZNF639 | Zinc finger protein 639 (Zinc finger protein ANC_2H01) (Zinc finger protein ZASC1) | 5 | UniProt NCBI |
| ZFP82 | Zinc finger protein 82 homolog (Zfp-82) (Zinc finger protein 545) | 3 | UniProt NCBI |
| ZBTB25 | Zinc finger and BTB domain-containing protein 25 (Zinc finger protein 46) (Zinc finger protein KUP) | 5 | UniProt NCBI |
| AR | Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) | 5 | UniProt NCBI |
| CDH2 | Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325) | 5 | UniProt NCBI |
| NR3C1 | Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) | 5 | UniProt NCBI |
| CTNNB1 | Catenin beta-1 (Beta-catenin) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0025380 | 0.00388470114881 | 0.333333333333 | CTNNB1 NR3C1 | Increased circulating androstenedione concentration |
| HP:0033811 | 0.00485499013014 | 0.333333333333 | CTNNB1 NR3C1 | Abnormal circulating androstenedione concentration |
| HP:0003466 | 0.00841070885474 | 0.333333333333 | CTNNB1 NR3C1 | Paradoxical increased cortisol secretion on dexamethasone suppression test |
| HP:0012029 | 0.00981070246055 | 0.333333333333 | CTNNB1 NR3C1 | Abnormal urine hormone level |
| HP:0012030 | 0.00981070246055 | 0.333333333333 | CTNNB1 NR3C1 | Increased urinary cortisol level |
| HP:0030348 | 0.0129324670968 | 0.333333333333 | CTNNB1 NR3C1 | Increased circulating androgen concentration |
| WP:WP2840 | 0.0207183951349 | 0.333333333333 | CTNNB1 NR3C1 | Hair follicle development cytodifferentiation part 3 of 3 |
| HP:0003118 | 0.0297012565438 | 0.333333333333 | CTNNB1 NR3C1 | Increased circulating cortisol level |
| CORUM:5262 | 0.0499436884912 | 0.166666666667 | CTNNB1 | TCF4-CTNNB1 complex |
| CORUM:5281 | 0.0499436884912 | 0.166666666667 | CTNNB1 | Cell-cell junction complex (CDH1-CTNNB1) |
| CORUM:6336 | 0.0499436884912 | 0.166666666667 | CTNNB1 | CTNNB1-DNMT1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CTNNB1 | MTERF2 | 0.989 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NR3C1 | AR | 0.988 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| CTNNB1 | NR3C1 | 0.986 | 0.1 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| ZBTB25 | CTNNB1 | 0.984 | 0.076 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ZFP82 | CTNNB1 | 0.983 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CDH2 | CTNNB1 | 0.98 | 0.366 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| ZNF639 | CTNNB1 | 0.979 | 0.108 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ZBTB25 | ZNF639 | 0.966 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only | |
| ZFP82 | MTERF2 | 0.946 | bioplex3_WMM WMM_only | ||
| ZBTB25 | ZFP82 | 0.946 | bioplex3_WMM WMM_only | ||
| NR3C1 | MTERF2 | 0.939 | bioplex3_WMM WMM_only | ||
| ZBTB25 | MTERF2 | 0.931 | bioplex3_WMM WMM_only | ||
| ZFP82 | NR3C1 | 0.893 | bioplex3_WMM youn_WMM WMM_only | ||
| ZNF639 | ZFP82 | 0.826 | bioplex3_WMM WMM_only | ||
| ZNF639 | MTERF2 | 0.795 | bioplex3_WMM WMM_only | ||
| ZBTB25 | NR3C1 | 0.77 | 0.056 | bioplex3_WMM WMM_only | |
| ZNF639 | NR3C1 | 0.435 | 0.074 | bioplex3_WMM WMM_only | |
| ZBTB25 | CDH2 | 0.092 | 0.056 | bioplex3_WMM WMM_only | |
| CDH2 | NR3C1 | 0.064 | 0.104 |
mutually_exclusive (P35222)
|
bioplex3_WMM WMM_only |
| ZFP82 | CDH2 | 0.062 | bioplex3_WMM WMM_only | ||
| CDH2 | MTERF2 | 0.044 | bioplex3_WMM WMM_only | ||
| ZNF639 | CDH2 | 0.04 | 0.06 | bioplex3_WMM WMM_only |
Related Complexes