hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12035.1
Complex Portal: CPX-16981
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ORC2 | Origin recognition complex subunit 2 | 5 | UniProt NCBI |
| CARTPT | Cocaine- and amphetamine-regulated transcript protein [Cleaved into: CART(1-39); CART(42-89)] | 5 | UniProt NCBI |
| SARS2 | Serine--tRNA ligase, mitochondrial (EC 6.1.1.11) (SerRSmt) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase) | 5 | UniProt NCBI |
| LRWD1 | Leucine-rich repeat and WD repeat-containing protein 1 (Centromere protein 33) (CENP-33) (Origin recognition complex-associated protein) (ORC-associated protein) (ORCA) | 5 | UniProt NCBI |
| ORC3 | Origin recognition complex subunit 3 (Origin recognition complex subunit Latheo) | 5 | UniProt NCBI |
| ALKBH4 | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (Alkylated DNA repair protein alkB homolog 4) (DNA N6-methyl adenine demethylase ALKBH4) (EC 1.14.11.51) (Lysine-specific demethylase ALKBH4) (EC 1.14.11.-) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1032 | 5.12534978153e-05 | 0.333333333333 | ORC2 ORC3 | ORC 2-4 complex (origin recognition 2-4 complex) |
| CORUM:5251 | 0.000102488289015 | 0.333333333333 | ORC2 ORC3 | Ku-ORC complex |
| CORUM:1034 | 0.000102488289015 | 0.333333333333 | ORC2 ORC3 | ORC 2-5 complex (origin recognition 2-5 complex) |
| GO:0000808 | 0.00010757157937 | 0.5 | ORC2 LRWD1 ORC3 | origin recognition complex |
| GO:0005664 | 0.00010757157937 | 0.5 | ORC2 LRWD1 ORC3 | nuclear origin of replication recognition complex |
| CORUM:1038 | 0.000170782642132 | 0.333333333333 | ORC2 ORC3 | ORC 1-5 complex (origin recognition 1-5 complex) |
| CORUM:1033 | 0.00025612721106 | 0.333333333333 | ORC2 ORC3 | ORC complex (origin recognition complex) |
| CORUM:1031 | 0.00025612721106 | 0.333333333333 | ORC2 ORC3 | ORC complex (origin recognition complex) |
| CORUM:389 | 0.00025612721106 | 0.333333333333 | ORC2 ORC3 | ORC complex (origin recognition complex) |
| REAC:R-HSA-68689 | 0.000722165722116 | 0.333333333333 | ORC2 ORC3 | CDC6 association with the ORC:origin complex |
| REAC:R-HSA-113507 | 0.000928329318648 | 0.333333333333 | ORC2 ORC3 | E2F-enabled inhibition of pre-replication complex formation |
| REAC:R-HSA-113510 | 0.00594265866298 | 0.333333333333 | ORC2 ORC3 | E2F mediated regulation of DNA replication |
| WP:WP466 | 0.00861234767009 | 0.333333333333 | ORC2 ORC3 | DNA replication |
| GO:0006270 | 0.00949259421943 | 0.5 | ORC2 LRWD1 ORC3 | DNA replication initiation |
| REAC:R-HSA-68962 | 0.0135559590666 | 0.333333333333 | ORC2 ORC3 | Activation of the pre-replicative complex |
| REAC:R-HSA-176187 | 0.0161658624528 | 0.333333333333 | ORC2 ORC3 | Activation of ATR in response to replication stress |
| WP:WP45 | 0.0200845776786 | 0.333333333333 | ORC2 ORC3 | G1 to S cell cycle control |
| REAC:R-HSA-68616 | 0.0407966660198 | 0.333333333333 | ORC2 ORC3 | Assembly of the ORC complex at the origin of replication |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ORC2 | LRWD1 | 1.0 | 0.22 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () Malo gupta_WMM fraction | |
| ALKBH4 | ORC3 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ALKBH4 | ORC2 | 0.999 | 0.02 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ORC2 | ORC3 | 0.995 | bioplex_WMM bioplex3_WMM youn_WMM Malo gupta_WMM fraction | ||
| ALKBH4 | LRWD1 | 0.991 | 0.076 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LRWD1 | SARS2 | 0.99 | 0.036 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| ORC2 | CARTPT | 0.958 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ORC3 | CARTPT | 0.95 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| LRWD1 | ORC3 | 0.858 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| LRWD1 | CARTPT | 0.755 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| CARTPT | SARS2 | 0.106 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ORC3 | SARS2 | 0.01 | bioplex3_WMM youn_WMM WMM_only | ||
| ORC2 | SARS2 | 0.005 | 0.02 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes