hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12044.1
Complex Portal: CPX-16114
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GRIN2B | Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3) | 5 | UniProt NCBI |
| LY6D | Lymphocyte antigen 6D (Ly-6D) (E48 antigen) | 5 | UniProt NCBI |
| GRIN2A | Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) (hNR2A) | 5 | UniProt NCBI |
| HIGD2A | HIG1 domain family member 2A, mitochondrial (RCF1 homolog B) (RCF1b) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5398 | 0.000232143427839 | 0.5 | GRIN2B GRIN2A | NRXN1 deletion syndrome |
| KEGG:05033 | 0.00069087933531 | 0.5 | GRIN2B GRIN2A | Nicotine addiction |
| WP:WP4875 | 0.000764539714508 | 0.5 | GRIN2B GRIN2A | Disruption of postsynaptic signaling by CNV |
| WP:WP4698 | 0.000894348084449 | 0.5 | GRIN2B GRIN2A | Vitamin D sensitive calcium signaling in depression |
| REAC:R-HSA-9022699 | 0.00107524337392 | 0.5 | GRIN2B GRIN2A | MECP2 regulates neuronal receptors and channels |
| REAC:R-HSA-438066 | 0.0013924419067 | 0.5 | GRIN2B GRIN2A | Unblocking of NMDA receptors, glutamate binding and activation |
| REAC:R-HSA-9617324 | 0.0013924419067 | 0.5 | GRIN2B GRIN2A | Negative regulation of NMDA receptor-mediated neuronal transmission |
| REAC:R-HSA-9620244 | 0.00156635412759 | 0.5 | GRIN2B GRIN2A | Long-term potentiation |
| REAC:R-HSA-8849932 | 0.00156635412759 | 0.5 | GRIN2B GRIN2A | Synaptic adhesion-like molecules |
| WP:WP4008 | 0.00169541860832 | 0.5 | GRIN2B GRIN2A | NO cGMP PKG mediated neuroprotection |
| WP:WP4222 | 0.00178944501344 | 0.5 | GRIN2B GRIN2A | Phosphodiesterases in neuronal function |
| KEGG:05030 | 0.00204942716049 | 0.5 | GRIN2B GRIN2A | Cocaine addiction |
| WP:WP4312 | 0.002190823719 | 0.5 | GRIN2B GRIN2A | Rett syndrome causing genes |
| WP:WP4539 | 0.002406667175 | 0.5 | GRIN2B GRIN2A | Synaptic signaling pathways associated with autism spectrum disorder |
| KEGG:04720 | 0.00357225272753 | 0.5 | GRIN2B GRIN2A | Long-term potentiation |
| KEGG:05031 | 0.00398305490854 | 0.5 | GRIN2B GRIN2A | Amphetamine addiction |
| KEGG:04713 | 0.00654897197861 | 0.5 | GRIN2B GRIN2A | Circadian entrainment |
| REAC:R-HSA-9609736 | 0.00718390333861 | 0.5 | GRIN2B GRIN2A | Assembly and cell surface presentation of NMDA receptors |
| KEGG:04724 | 0.00806816574582 | 0.5 | GRIN2B GRIN2A | Glutamatergic synapse |
| GO:0022849 | 0.00842684400117 | 0.5 | GRIN2B GRIN2A | glutamate-gated calcium ion channel activity |
| REAC:R-HSA-6794361 | 0.0105688559686 | 0.5 | GRIN2B GRIN2A | Neurexins and neuroligins |
| WP:WP5380 | 0.011545786253 | 0.5 | GRIN2B HIGD2A | 5q35 copy number variation |
| REAC:R-HSA-8986944 | 0.0140623832262 | 0.5 | GRIN2B GRIN2A | Transcriptional Regulation by MECP2 |
| KEGG:05322 | 0.014352694406 | 0.5 | GRIN2B GRIN2A | Systemic lupus erythematosus |
| KEGG:04728 | 0.014619629343 | 0.5 | GRIN2B GRIN2A | Dopaminergic synapse |
| WP:WP4549 | 0.0151597078239 | 0.5 | GRIN2B GRIN2A | Fragile X syndrome |
| WP:WP5083 | 0.0154364529098 | 0.5 | GRIN2B GRIN2A | Neuroinflammation and glutamatergic signaling |
| GO:0098976 | 0.0168521501606 | 0.5 | GRIN2B GRIN2A | excitatory chemical synaptic transmission |
| KEGG:05017 | 0.0192212154966 | 0.5 | GRIN2B GRIN2A | Spinocerebellar ataxia |
| REAC:R-HSA-438064 | 0.0232149434748 | 0.5 | GRIN2B GRIN2A | Post NMDA receptor activation events |
| REAC:R-HSA-6794362 | 0.0246065982605 | 0.5 | GRIN2B GRIN2A | Protein-protein interactions at synapses |
| WP:WP4223 | 0.0270438297073 | 0.5 | GRIN2B GRIN2A | Ras signaling |
| KEGG:05034 | 0.0272860662684 | 0.5 | GRIN2B GRIN2A | Alcoholism |
| GO:0017146 | 0.0280843539964 | 0.5 | GRIN2B GRIN2A | NMDA selective glutamate receptor complex |
| GO:0004972 | 0.0280843539964 | 0.5 | GRIN2B GRIN2A | NMDA glutamate receptor activity |
| KEGG:04024 | 0.0306683825257 | 0.5 | GRIN2B GRIN2A | cAMP signaling pathway |
| REAC:R-HSA-442755 | 0.0321680026233 | 0.5 | GRIN2B GRIN2A | Activation of NMDA receptors and postsynaptic events |
| KEGG:04015 | 0.0338381888916 | 0.5 | GRIN2B GRIN2A | Rap1 signaling pathway |
| KEGG:04020 | 0.036316189849 | 0.5 | GRIN2B GRIN2A | Calcium signaling pathway |
| KEGG:04014 | 0.0415303647194 | 0.5 | GRIN2B GRIN2A | Ras signaling pathway |
| KEGG:04080 | 0.0428875882852 | 0.5 | GRIN2B GRIN2A | Neuroactive ligand-receptor interaction |
| CORUM:7240 | 0.049938562206 | 0.25 | GRIN2A | CHRNA7-GRIN2A complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| GRIN2B | GRIN2A | 0.99 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| LY6D | GRIN2A | 0.873 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| HIGD2A | GRIN2A | 0.871 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| HIGD2A | GRIN2B | 0.415 | bioplex3_WMM WMM_only |
Related Complexes