hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12051.1
Complex Portal: CPX-19388
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PDCD6 | Programmed cell death protein 6 (Apoptosis-linked gene 2 protein homolog) (ALG-2) | 5 | UniProt NCBI |
| RNF43 | E3 ubiquitin-protein ligase RNF43 (EC 2.3.2.27) (RING finger protein 43) (RING-type E3 ubiquitin transferase RNF43) | 5 | UniProt NCBI |
| PEF1 | Peflin (PEF protein with a long N-terminal hydrophobic domain) (Penta-EF hand domain-containing protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6375 | 3.41752350426e-06 | 0.666666666667 | PDCD6 PEF1 | PEF1-ALG2 complex |
| CORUM:7522 | 2.05032700758e-05 | 0.666666666667 | PDCD6 PEF1 | Ubiquitin E3 ligase (CUL3, KLHL12, PEF1, PDCD6) |
| GO:1902525 | 0.0140440992017 | 0.666666666667 | PDCD6 PEF1 | regulation of protein monoubiquitination |
| GO:1902527 | 0.0140440992017 | 0.666666666667 | PDCD6 PEF1 | positive regulation of protein monoubiquitination |
| CORUM:7564 | 0.0499402709677 | 0.333333333333 | RNF43 | LGR5-RNF43-RSPO1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PDCD6 | PEF1 | 0.992 | 0.198 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction | |
| RNF43 | PEF1 | 0.836 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| RNF43 | PDCD6 | 0.011 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes
| Genename | Complexes |
|---|---|
| PDCD6 | huMAP3_01795.1 huMAP3_12051.1 huMAP3_12917.1 huMAP3_13805.1 |
| RNF43 | huMAP3_00459.1 huMAP3_12051.1 huMAP3_13390.1 huMAP3_14089.1 huMAP3_15225.1 |
| PEF1 | huMAP3_01795.1 huMAP3_12051.1 huMAP3_13390.1 |