hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12055.1
Complex Portal: CPX-20498
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ACACA | Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha) | 5 | UniProt NCBI |
| TSSK4 | Testis-specific serine/threonine-protein kinase 4 (TSK-4) (TSSK-4) (Testis-specific kinase 4) (EC 2.7.11.1) (Serine/threonine-protein kinase 22E) | 5 | UniProt NCBI |
| THRSP | Thyroid hormone-inducible hepatic protein (Spot 14 protein) (S14) (SPOT14) | 5 | UniProt NCBI |
| OR52H1 | Olfactory receptor 52H1 (Olfactory receptor OR11-45) | 3 | UniProt NCBI |
| MID1IP1 | Mid1-interacting protein 1 (Gastrulation-specific G12-like protein) (Mid1-interacting G12-like protein) (Protein STRAIT11499) (Spot 14-related protein) (S14R) (Spot 14-R) | 4 | UniProt NCBI |
| ACACB | Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-200425 | 1.03648861546e-09 | 0.666666666667 | ACACB ACACA THRSP MID1IP1 | Carnitine metabolism |
| REAC:R-HSA-8978868 | 2.59487269289e-05 | 0.666666666667 | ACACB ACACA THRSP MID1IP1 | Fatty acid metabolism |
| WP:WP5031 | 0.000362274856058 | 0.333333333333 | ACACA ACACB | Biotin metabolism including IMDs |
| REAC:R-HSA-163765 | 0.000541723162524 | 0.333333333333 | ACACA ACACB | ChREBP activates metabolic gene expression |
| KEGG:00061 | 0.000761561454439 | 0.333333333333 | ACACA ACACB | Fatty acid biosynthesis |
| REAC:R-HSA-196780 | 0.0014177632075 | 0.333333333333 | ACACA ACACB | Biotin transport and metabolism |
| WP:WP4206 | 0.00190817031826 | 0.333333333333 | ACACA ACACB | Hereditary leiomyomatosis and renal cell carcinoma pathway |
| WP:WP357 | 0.00210864528598 | 0.333333333333 | ACACA ACACB | Fatty acid biosynthesis |
| KEGG:00640 | 0.00336278970932 | 0.333333333333 | ACACA ACACB | Propanoate metabolism |
| KEGG:00620 | 0.00651602067746 | 0.333333333333 | ACACA ACACB | Pyruvate metabolism |
| GO:0003989 | 0.00702301080125 | 0.333333333333 | ACACA ACACB | acetyl-CoA carboxylase activity |
| REAC:R-HSA-556833 | 0.00784925061173 | 0.666666666667 | ACACB ACACA THRSP MID1IP1 | Metabolism of lipids |
| REAC:R-HSA-2426168 | 0.0170865043842 | 0.333333333333 | ACACA ACACB | Activation of gene expression by SREBF (SREBP) |
| WP:WP1403 | 0.0182415379951 | 0.333333333333 | ACACA ACACB | AMP activated protein kinase signaling |
| WP:WP2034 | 0.0226781844519 | 0.333333333333 | ACACA ACACB | Leptin signaling pathway |
| WP:WP4018 | 0.0275906315528 | 0.333333333333 | ACACA ACACB | Clear cell renal cell carcinoma pathways |
| KEGG:04922 | 0.0299366365218 | 0.333333333333 | ACACA ACACB | Glucagon signaling pathway |
| REAC:R-HSA-1655829 | 0.0313533174732 | 0.333333333333 | ACACA ACACB | Regulation of cholesterol biosynthesis by SREBP (SREBF) |
| KEGG:04152 | 0.045081780015 | 0.333333333333 | ACACA ACACB | AMPK signaling pathway |
| WP:WP4932 | 0.0451642815361 | 0.333333333333 | ACACA ACACB | 7q11 23 copy number variation syndrome |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ACACB | MID1IP1 | 0.995 | 0.078 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MID1IP1 | ACACA | 0.99 | 0.076 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MID1IP1 | THRSP | 0.99 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ACACB | TSSK4 | 0.988 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| OR52H1 | ACACB | 0.954 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| THRSP | ACACA | 0.945 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ACACB | THRSP | 0.908 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ACACB | ACACA | 0.884 | 0.952 | bioplex3_HEK293 bioplex3_WMM gupta_WMM WMM_only boldt_WMM treiber_WMM | |
| OR52H1 | MID1IP1 | 0.078 | bioplex3_WMM WMM_only | ||
| OR52H1 | ACACA | 0.076 | bioplex3_WMM WMM_only | ||
| ACACA | TSSK4 | 0.019 | bioplex3_HCT116 WMM_only |
Related Complexes