hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12060.1
Complex Portal: CPX-21027
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CCSER1 | Serine-rich coiled-coil domain-containing protein 1 (Coiled-coil serine-rich protein 1) | 3 | UniProt NCBI |
| PAFAH1B3 | Platelet-activating factor acetylhydrolase IB subunit alpha1 (EC 3.1.1.47) (PAF acetylhydrolase 29 kDa subunit) (PAF-AH 29 kDa subunit) (PAF-AH subunit gamma) (PAFAH subunit gamma) | 5 | UniProt NCBI |
| FAM124A | Protein FAM124A | 5 | UniProt NCBI |
| PAFAH1B1 | Platelet-activating factor acetylhydrolase IB subunit beta (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha) | 5 | UniProt NCBI |
| CCSER2 | Serine-rich coiled-coil domain-containing protein 2 (Coiled-coil serine-rich protein 2) (Protein GCAP14 homolog) | 4 | UniProt NCBI |
| PAFAH1B2 | Platelet-activating factor acetylhydrolase IB subunit alpha2 (EC 3.1.1.47) (PAF acetylhydrolase 30 kDa subunit) (PAF-AH 30 kDa subunit) (PAF-AH subunit beta) (PAFAH subunit beta) | 5 | UniProt NCBI |
| DIXDC1 | Dixin (Coiled-coil protein DIX1) (Coiled-coil-DIX1) (DIX domain-containing protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5409 | 7.30297581269e-07 | 0.428571428571 | PAFAH1B2 PAFAH1B3 PAFAH1B1 | PAFAH1B1 copy number variation |
| GO:0008247 | 3.36420143768e-06 | 0.428571428571 | PAFAH1B2 PAFAH1B3 PAFAH1B1 | 1-alkyl-2-acetylglycerophosphocholine esterase complex |
| KEGG:00565 | 2.70958958847e-05 | 0.428571428571 | PAFAH1B2 PAFAH1B3 PAFAH1B1 | Ether lipid metabolism |
| REAC:R-HSA-6811436 | 0.000253118097004 | 0.428571428571 | PAFAH1B2 PAFAH1B3 PAFAH1B1 | COPI-independent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-8856688 | 0.00413825544794 | 0.428571428571 | PAFAH1B2 PAFAH1B3 PAFAH1B1 | Golgi-to-ER retrograde transport |
| REAC:R-HSA-6811442 | 0.0147908747224 | 0.428571428571 | PAFAH1B2 PAFAH1B3 PAFAH1B1 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| GO:0047179 | 0.0294899169624 | 0.285714285714 | PAFAH1B2 PAFAH1B3 | platelet-activating factor acetyltransferase activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PAFAH1B3 | PAFAH1B2 | 1.0 | 0.406 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 boldt_WMM |
| PAFAH1B1 | PAFAH1B3 | 0.999 | 0.048 |
structurally_consistent (P68402)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 fraction boldt_WMM |
| PAFAH1B1 | PAFAH1B2 | 0.997 | 0.52 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 fraction boldt_WMM |
| CCSER2 | PAFAH1B1 | 0.982 | 0.0977 | hein_WMM bioplex_WMM bioplex3_WMM hein () gupta_WMM | |
| DIXDC1 | PAFAH1B1 | 0.961 | 0.1 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| DIXDC1 | FAM124A | 0.94 | 0.048 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| CCSER2 | DIXDC1 | 0.902 | 0.108 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| CCSER1 | PAFAH1B1 | 0.893 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| CCSER1 | CCSER2 | 0.885 |
mutually_exclusive (Q9GZM8)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| CCSER1 | DIXDC1 | 0.735 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CCSER2 | PAFAH1B3 | 0.192 | 0.048 | hein_WMM WMM_only | |
| CCSER2 | PAFAH1B2 | 0.192 | 0.076 | hein_WMM WMM_only | |
| DIXDC1 | PAFAH1B2 | 0.063 | 0.04 | hein_WMM WMM_only | |
| DIXDC1 | PAFAH1B3 | 0.063 | 0.06 | hein_WMM WMM_only |
Related Complexes