hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12061.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LDHC | L-lactate dehydrogenase C chain (LDH-C) (EC 1.1.1.27) (Cancer/testis antigen 32) (CT32) (LDH testis subunit) (LDH-X) | 5 | UniProt NCBI |
| LDHA | L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) | 5 | UniProt NCBI |
| LDHB | L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) | 5 | UniProt NCBI |
| LDHAL6A | L-lactate dehydrogenase A-like 6A (LDHA-like protein 6A) (EC 1.1.1.27) | 4 | UniProt NCBI |
| TMEM19 | Transmembrane protein 19 | 5 | UniProt NCBI |
| SLC24A3 | Sodium/potassium/calcium exchanger 3 (Na(+)/K(+)/Ca(2+)-exchange protein 3) (Solute carrier family 24 member 3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0004457 | 1.97323122031e-09 | 0.666666666667 | LDHAL6A LDHC LDHB LDHA | lactate dehydrogenase activity |
| GO:0004459 | 1.97323122031e-09 | 0.666666666667 | LDHAL6A LDHC LDHB LDHA | L-lactate dehydrogenase activity |
| KEGG:00640 | 1.28180254308e-08 | 0.666666666667 | LDHAL6A LDHC LDHB LDHA | Propanoate metabolism |
| REAC:R-HSA-70268 | 3.96532736613e-08 | 0.666666666667 | LDHAL6A LDHC LDHB LDHA | Pyruvate metabolism |
| GO:0006089 | 4.97036464355e-08 | 0.666666666667 | LDHAL6A LDHC LDHB LDHA | lactate metabolic process |
| KEGG:00620 | 5.02078982671e-08 | 0.666666666667 | LDHAL6A LDHC LDHB LDHA | Pyruvate metabolism |
| KEGG:00270 | 6.6368032535e-08 | 0.666666666667 | LDHAL6A LDHC LDHB LDHA | Cysteine and methionine metabolism |
| KEGG:00010 | 2.26479709725e-07 | 0.666666666667 | LDHAL6A LDHC LDHB LDHA | Glycolysis / Gluconeogenesis |
| KEGG:05230 | 3.11012631351e-07 | 0.666666666667 | LDHAL6A LDHC LDHB LDHA | Central carbon metabolism in cancer |
| REAC:R-HSA-71406 | 3.90777239142e-07 | 0.666666666667 | LDHAL6A LDHC LDHB LDHA | Pyruvate metabolism and Citric Acid (TCA) cycle |
| WP:WP4236 | 7.8760465306e-07 | 0.5 | LDHC LDHB LDHA | Krebs cycle disorders |
| KEGG:04922 | 1.13066508183e-06 | 0.666666666667 | LDHAL6A LDHC LDHB LDHA | Glucagon signaling pathway |
| KEGG:04066 | 1.52209570373e-06 | 0.666666666667 | LDHAL6A LDHC LDHB LDHA | HIF-1 signaling pathway |
| WP:WP534 | 3.14733202476e-05 | 0.5 | LDHC LDHB LDHA | Glycolysis and gluconeogenesis |
| REAC:R-HSA-1428517 | 4.67320107294e-05 | 0.666666666667 | LDHAL6A LDHC LDHB LDHA | The citric acid (TCA) cycle and respiratory electron transport |
| WP:WP4018 | 0.000184184400096 | 0.5 | LDHC LDHB LDHA | Clear cell renal cell carcinoma pathways |
| WP:WP5355 | 0.000278673368084 | 0.5 | LDHC LDHB LDHA | Metabolic Epileptic Disorders |
| WP:WP5314 | 0.00055327344683 | 0.333333333333 | LDHA LDHB | Lactate shuttle in glial cells |
| GO:0006090 | 0.000911926366134 | 0.666666666667 | LDHAL6A LDHC LDHB LDHA | pyruvate metabolic process |
| GO:0016616 | 0.00165931249978 | 0.666666666667 | LDHAL6A LDHC LDHB LDHA | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| GO:0016614 | 0.00225224503687 | 0.666666666667 | LDHAL6A LDHC LDHB LDHA | oxidoreductase activity, acting on CH-OH group of donors |
| KEGG:01100 | 0.0414134615413 | 0.666666666667 | LDHAL6A LDHC LDHB LDHA | Metabolic pathways |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| LDHC | LDHA | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction | |
| LDHB | LDHC | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| LDHB | LDHA | 0.997 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM | |
| LDHC | LDHAL6A | 0.974 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TMEM19 | LDHA | 0.863 | bioplex3_WMM WMM_only | |
| LDHC | SLC24A3 | 0.857 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| LDHAL6A | LDHA | 0.825 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LDHB | LDHAL6A | 0.069 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LDHB | SLC24A3 | 0.053 | bioplex3_HEK293 WMM_only | |
| LDHA | SLC24A3 | 0.018 | bioplex3_HEK293 WMM_only | |
| LDHB | TMEM19 | 0.016 | 0.052 | bioplex3_WMM WMM_only |
Related Complexes