hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_12069.1

Complex Portal: CPX-21203

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
SDHAF3	Succinate dehydrogenase assembly factor 3, mitochondrial (SDH assembly factor 3) (SDHAF3)	2	UniProt NCBI
SDHAF2	Succinate dehydrogenase assembly factor 2, mitochondrial (SDH assembly factor 2) (SDHAF2)	5	UniProt NCBI
HGF	Hepatocyte growth factor (Hepatopoietin-A) (Scatter factor) (SF) [Cleaved into: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain]	5	UniProt NCBI
SDHAF4	Succinate dehydrogenase assembly factor 4, mitochondrial (SDH assembly factor 4) (SDHAF4)	4	UniProt NCBI
SDHB	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC 1.3.5.1) (Iron-sulfur subunit of complex II) (Ip)	5	UniProt NCBI
SDHA	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC 1.3.5.1) (Flavoprotein subunit of complex II) (Fp)	5	UniProt NCBI
SDHC	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (Integral membrane protein CII-3) (QPs-1) (QPs1) (Succinate dehydrogenase complex subunit C) (Succinate-ubiquinone oxidoreductase cytochrome B large subunit) (CYBL)	5	UniProt NCBI
DHODH	Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase) (EC 1.3.5.2) (Dihydroorotate oxidase)	5	UniProt NCBI
TMEM95	Sperm-egg fusion protein TMEM95 (Transmembrane protein 95)	4	UniProt NCBI
SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial (CybS) (CII-4) (QPs3) (Succinate dehydrogenase complex subunit D) (Succinate-ubiquinone oxidoreductase cytochrome b small subunit) (Succinate-ubiquinone reductase membrane anchor subunit)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP4920	5.28918727849e-18	0.75	SDHAF2 SDHA SDHC SDHD SDHAF3 SDHAF4	Mitochondrial complex II assembly
HP:0001686	4.76140718857e-10	0.5	SDHAF2 SDHA SDHD SDHC	Loss of voice
GO:0006121	9.20740386965e-09	0.5	SDHAF2 SDHA SDHD SDHC	mitochondrial electron transport, succinate to ubiquinone
HP:0002864	4.32434495125e-08	0.5	SDHAF2 SDHA SDHD SDHC	Paraganglioma of head and neck
HP:0000740	4.32434495125e-08	0.5	SDHAF2 SDHA SDHD SDHC	Episodic paroxysmal anxiety
HP:0002640	4.32434495125e-08	0.5	SDHAF2 SDHA SDHD SDHC	Hypertension associated with pheochromocytoma
HP:0009711	4.32434495125e-08	0.5	SDHAF2 SDHA SDHD SDHC	Retinal capillary hemangioma
HP:0008629	4.32434495125e-08	0.5	SDHAF2 SDHA SDHD SDHC	Pulsatile tinnitus
HP:0003345	4.32434495125e-08	0.5	SDHAF2 SDHA SDHD SDHC	Elevated urinary norepinephrine level
HP:0011979	4.32434495125e-08	0.5	SDHAF2 SDHA SDHD SDHC	Elevated urinary dopamine level
HP:0003574	4.32434495125e-08	0.5	SDHAF2 SDHA SDHD SDHC	Positive regitine blocking test
HP:0003639	4.32434495125e-08	0.5	SDHAF2 SDHA SDHD SDHC	Elevated urinary epinephrine level
HP:0012222	4.32434495125e-08	0.5	SDHAF2 SDHA SDHD SDHC	Arachnoid hemangiomatosis
HP:0006737	4.32434495125e-08	0.5	SDHAF2 SDHA SDHD SDHC	Extraadrenal pheochromocytoma
HP:0006748	5.76452981851e-08	0.5	SDHAF2 SDHA SDHD SDHC	Adrenal pheochromocytoma
HP:0010532	5.76452981851e-08	0.5	SDHAF2 SDHA SDHD SDHC	Paroxysmal vertigo
HP:0100642	5.76452981851e-08	0.5	SDHAF2 SDHA SDHD SDHC	Neoplasm of the adrenal medulla
HP:0010797	7.53657938041e-08	0.5	SDHAF2 SDHA SDHD SDHC	Hemangioblastoma
HP:0001095	7.53657938041e-08	0.5	SDHAF2 SDHA SDHD SDHC	Hypertensive retinopathy
HP:0002668	9.6877642404e-08	0.5	SDHAF2 SDHA SDHD SDHC	Paraganglioma
HP:0011976	1.53322372488e-07	0.5	SDHAF2 SDHA SDHD SDHC	Elevated urinary catecholamine level
HP:0011281	1.53322372488e-07	0.5	SDHAF2 SDHA SDHD SDHC	Abnormality of urine catecholamine level
HP:0003528	1.53322372488e-07	0.5	SDHAF2 SDHA SDHD SDHC	Elevated circulating calcitonin concentration
HP:0034902	1.53322372488e-07	0.5	SDHAF2 SDHA SDHD SDHC	Abnormal circulating calcitonin concentration
HP:0009594	1.89356712338e-07	0.5	SDHAF2 SDHA SDHD SDHC	Retinal hamartoma
HP:0002331	2.80036539718e-07	0.5	SDHAF2 SDHA SDHD SDHC	Recurrent paroxysmal headache
HP:0011703	3.35970182629e-07	0.5	SDHAF2 SDHA SDHD SDHC	Sinus tachycardia
HP:0030074	3.71126957735e-07	0.375	SDHAF2 SDHD SDHC	Chemodectoma
HP:0010568	3.99876821683e-07	0.5	SDHAF2 SDHA SDHD SDHC	Hamartoma of the eye
HP:0030670	3.99876821683e-07	0.5	SDHAF2 SDHA SDHD SDHC	Hamartoma of the orbital region
HP:0001069	3.99876821683e-07	0.5	SDHAF2 SDHA SDHD SDHC	Episodic hyperhidrosis
HP:0002666	4.72478092576e-07	0.5	SDHAF2 SDHA SDHD SDHC	Pheochromocytoma
HP:0002574	8.6534513212e-07	0.5	SDHAF2 SDHA SDHD SDHC	Episodic abdominal pain
HP:0003001	9.27579271823e-07	0.375	SDHAF2 SDHD SDHC	Glomus jugular tumor
HP:0032148	1.13498137973e-06	0.5	SDHAF2 SDHA SDHD SDHC	Episodic pain
HP:0100530	1.29124729367e-06	0.5	SDHAF2 SDHA SDHD SDHC	Abnormal circulating calcium-phosphate regulating hormone concentration
HP:0100634	1.46309264702e-06	0.5	SDHAF2 SDHA SDHD SDHC	Neuroendocrine neoplasm
HP:0000526	2.59204993656e-06	0.5	SDHAF2 SDHA SDHD SDHC	Aniridia
HP:0100631	2.87942365626e-06	0.5	SDHAF2 SDHA SDHD SDHC	Neoplasm of the adrenal gland
HP:0100012	3.88571869614e-06	0.5	SDHAF2 SDHA SDHD SDHC	Neoplasm of the eye
HP:0031801	3.88571869614e-06	0.5	SDHAF2 SDHA SDHD SDHC	Vocal cord dysfunction
HP:0001605	3.88571869614e-06	0.5	SDHAF2 SDHA SDHD SDHC	Vocal cord paralysis
HP:0001293	3.88571869614e-06	0.5	SDHAF2 SDHA SDHD SDHC	Cranial nerve compression
HP:0031284	4.27335268869e-06	0.5	SDHAF2 SDHA SDHD SDHC	Flushing
HP:0025269	7.2401525095e-06	0.5	SDHAF2 SDHA SDHD SDHC	Panic attack
WP:WP78	7.98434088212e-06	0.375	SDHC SDHA SDHD	TCA cycle aka Krebs or citric acid cycle
HP:0000360	9.93354606521e-06	0.5	SDHAF2 SDHA SDHD SDHC	Tinnitus
HP:0010566	1.23992213916e-05	0.5	SDHAF2 SDHA SDHD SDHC	Hamartoma
HP:0001342	1.23992213916e-05	0.5	SDHAF2 SDHA SDHD SDHC	Cerebral hemorrhage
HP:0003072	1.33147580685e-05	0.5	SDHAF2 SDHA SDHD SDHC	Hypercalcemia
HP:0100007	1.63664569014e-05	0.5	SDHAF2 SDHA SDHD SDHC	Neoplasm of the peripheral nervous system
HP:0001291	1.63664569014e-05	0.5	SDHAF2 SDHA SDHD SDHC	Abnormal cranial nerve morphology
HP:0005584	1.86730872519e-05	0.5	SDHAF2 SDHA SDHD SDHC	Renal cell carcinoma
GO:0006099	1.94862705925e-05	0.5	SDHAF2 SDHA SDHD SDHC	tricarboxylic acid cycle
HP:0011702	1.99135850848e-05	0.5	SDHAF2 SDHA SDHD SDHC	Abnormal electrophysiology of sinoatrial node origin
KEGG:00020	2.14879728377e-05	0.375	SDHC SDHA SDHD	Citrate cycle (TCA cycle)
GO:0045281	2.15253635486e-05	0.375	SDHC SDHA SDHD	succinate dehydrogenase complex
GO:0045283	2.15253635486e-05	0.375	SDHC SDHA SDHD	fumarate reductase complex
GO:0034552	2.15253635486e-05	0.375	SDHAF3 SDHAF4 SDHAF2	respiratory chain complex II assembly
GO:0045273	2.15253635486e-05	0.375	SDHC SDHA SDHD	respiratory chain complex II
GO:0045257	2.15253635486e-05	0.375	SDHC SDHA SDHD	succinate dehydrogenase complex (ubiquinone)
GO:0005749	2.15253635486e-05	0.375	SDHC SDHA SDHD	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)
GO:0034553	2.15253635486e-05	0.375	SDHAF3 SDHAF4 SDHAF2	mitochondrial respiratory chain complex II assembly
REAC:R-HSA-71403	3.03234516525e-05	0.375	SDHC SDHA SDHD	Citric acid cycle (TCA cycle)
HP:0002018	4.69355516597e-05	0.5	SDHAF2 SDHA SDHD SDHC	Nausea
HP:0000096	5.19495358718e-05	0.5	SDHAF2 SDHA SDHD SDHC	Glomerular sclerosis
HP:0001962	6.02080792072e-05	0.5	SDHAF2 SDHA SDHD SDHC	Palpitations
HP:0100723	6.28813589663e-05	0.375	SDHC SDHA SDHD	Gastrointestinal stroma tumor
HP:0100833	6.28813589663e-05	0.375	SDHC SDHA SDHD	Neoplasm of the small intestine
HP:0031071	8.32696157954e-05	0.5	SDHAF2 SDHA SDHD SDHC	Abnormal endocrine morphology
HP:0011732	8.32696157954e-05	0.5	SDHAF2 SDHA SDHD SDHC	Abnormal adrenal morphology
HP:0100835	0.000121927901748	0.5	SDHAF2 SDHA SDHD SDHC	Benign neoplasm of the central nervous system
HP:0100749	0.000132079586227	0.5	SDHAF2 SDHA SDHD SDHC	Chest pain
HP:0000405	0.000170026002076	0.625	DHODH SDHAF2 SDHA SDHD SDHC	Conductive hearing impairment
HP:0011452	0.000184464620703	0.625	DHODH SDHAF2 SDHA SDHD SDHC	Functional abnormality of the middle ear
HP:0001618	0.000192611932556	0.5	SDHAF2 SDHA SDHD SDHC	Dysphonia
HP:0008053	0.000199636300587	0.5	SDHAF2 SDHA SDHD SDHC	Aplasia/Hypoplasia of the iris
HP:0008055	0.000199636300587	0.5	SDHAF2 SDHA SDHD SDHC	Aplasia/Hypoplasia affecting the uvea
HP:0002321	0.000206850251961	0.5	SDHAF2 SDHA SDHD SDHC	Vertigo
HP:0009726	0.000214257131294	0.5	SDHAF2 SDHA SDHD SDHC	Renal neoplasm
HP:0006715	0.000226027933833	0.25	SDHAF2 SDHD	Glomus tympanicum paraganglioma
HP:0002886	0.000226027933833	0.25	SDHAF2 SDHD	Vagal paraganglioma
HP:0010786	0.000254304465057	0.5	SDHAF2 SDHA SDHD SDHC	Urinary tract neoplasm
HP:0008062	0.000271794082941	0.5	SDHAF2 SDHA SDHD SDHC	Aplasia/Hypoplasia affecting the anterior segment of the eye
HP:0004363	0.00029969273526	0.5	SDHAF2 SDHA SDHD SDHC	Abnormal circulating calcium concentration
HP:0002170	0.000361842646163	0.5	SDHAF2 SDHA SDHD SDHC	Intracranial hemorrhage
HP:0033331	0.000361842646163	0.5	SDHAF2 SDHA SDHD SDHC	Acute phase response
HP:0100568	0.000396296239007	0.5	SDHAF2 SDHA SDHD SDHC	Neoplasm of the endocrine system
HP:0001028	0.000396296239007	0.5	SDHAF2 SDHA SDHD SDHC	Hemangioma
HP:0000980	0.000408306883514	0.5	SDHAF2 SDHA SDHD SDHC	Pallor
HP:0003470	0.000433140852756	0.5	SDHAF2 SDHA SDHD SDHC	Paralysis
HP:0100742	0.000445972109624	0.5	SDHAF2 SDHA SDHD SDHC	Vascular neoplasm
HP:0010927	0.000445972109624	0.5	SDHAF2 SDHA SDHD SDHC	Abnormal blood inorganic cation concentration
HP:0000975	0.000459084881468	0.5	SDHAF2 SDHA SDHD SDHC	Hyperhidrosis
REAC:R-HSA-71406	0.000499872649354	0.375	SDHC SDHA SDHD	Pyruvate metabolism and Citric Acid (TCA) cycle
GO:0045333	0.000530546258616	0.625	SDHAF2 SDHC SDHAF4 SDHD SDHA	cellular respiration
HP:0012614	0.000767242624533	0.5	SDHAF2 SDHA SDHD SDHC	Abnormal urine cytology
HP:0000790	0.000767242624533	0.5	SDHAF2 SDHA SDHD SDHC	Hematuria
HP:0100006	0.000786868782586	0.5	SDHAF2 SDHA SDHD SDHC	Neoplasm of the central nervous system
HP:0001751	0.000806866831728	0.5	SDHAF2 SDHA SDHD SDHC	Abnormal vestibular function
HP:0000095	0.000847997020233	0.5	SDHAF2 SDHA SDHD SDHC	Abnormal renal glomerulus morphology
HP:0031263	0.000869138434239	0.5	SDHAF2 SDHA SDHD SDHC	Abnormal renal corpuscle morphology
KEGG:01200	0.00094562799903	0.375	SDHC SDHA SDHD	Carbon metabolism
HP:0000834	0.00102832589131	0.5	SDHAF2 SDHA SDHD SDHC	Abnormality of the adrenal glands
HP:0004375	0.00112851080431	0.5	SDHAF2 SDHA SDHD SDHC	Neoplasm of the nervous system
HP:0100743	0.00113360622659	0.375	SDHC SDHA SDHD	Neoplasm of the rectum
WP:WP111	0.00145791004127	0.375	SDHC SDHA SDHD	Electron transport chain OXPHOS system in mitochondria
KEGG:00190	0.00152602370755	0.375	SDHC SDHA SDHD	Oxidative phosphorylation
HP:0007550	0.00163742493148	0.5	SDHAF2 SDHA SDHD SDHC	Hypohidrosis or hyperhidrosis
HP:0011035	0.00185241136758	0.5	SDHAF2 SDHA SDHD SDHC	Abnormal renal cortex morphology
HP:0025276	0.00189018749295	0.5	SDHAF2 SDHA SDHD SDHC	Abnormality of skin adnexa physiology
HP:0007379	0.00192853414724	0.5	SDHAF2 SDHA SDHD SDHC	Neoplasm of the genitourinary tract
HP:0000093	0.00192853414724	0.5	SDHAF2 SDHA SDHD SDHC	Proteinuria
GO:0015980	0.00213344193493	0.625	SDHAF2 SDHC SDHAF4 SDHD SDHA	energy derivation by oxidation of organic compounds
KEGG:04932	0.0022539548616	0.375	SDHC SDHA SDHD	Non-alcoholic fatty liver disease
GO:0019646	0.002326053637	0.5	SDHAF2 SDHA SDHD SDHC	aerobic electron transport chain
HP:0000370	0.00244760101111	0.625	DHODH SDHAF2 SDHA SDHD SDHC	Abnormality of the middle ear
HP:0020129	0.00267324865117	0.5	SDHAF2 SDHA SDHD SDHC	Abnormal urine protein level
HP:0008046	0.00272284792648	0.5	SDHAF2 SDHA SDHD SDHC	Abnormal retinal vascular morphology
HP:0012575	0.00277312854607	0.5	SDHAF2 SDHA SDHD SDHC	Abnormal nephron morphology
HP:0001635	0.00298118645851	0.5	SDHAF2 SDHA SDHD SDHC	Congestive heart failure
GO:0042773	0.00316689333881	0.5	SDHAF2 SDHA SDHD SDHC	ATP synthesis coupled electron transport
GO:0042775	0.00316689333881	0.5	SDHAF2 SDHA SDHD SDHC	mitochondrial ATP synthesis coupled electron transport
REAC:R-HSA-611105	0.00350506047164	0.375	SDHC SDHA SDHD	Respiratory electron transport
WP:WP4396	0.00397822087206	0.375	SDHC SDHA SDHD	Nonalcoholic fatty liver disease
HP:0005214	0.0043733297498	0.375	SDHC SDHA SDHD	Intestinal obstruction
GO:0022904	0.00482963771614	0.5	SDHAF2 SDHA SDHD SDHC	respiratory electron transport chain
KEGG:05415	0.0050295788442	0.375	SDHC SDHA SDHD	Diabetic cardiomyopathy
HP:0010929	0.00584390206375	0.5	SDHAF2 SDHA SDHD SDHC	Abnormal blood cation concentration
HP:0100780	0.0063183945919	0.25	SDHC SDHD	Conjunctival hamartoma
REAC:R-HSA-163200	0.00639902621489	0.375	SDHC SDHA SDHD	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
HP:0004796	0.00640296160267	0.375	SDHC SDHA SDHD	Gastrointestinal obstruction
GO:0022900	0.00679043955679	0.5	SDHAF2 SDHA SDHD SDHC	electron transport chain
KEGG:05208	0.00685237808039	0.375	SDHC SDHA SDHD	Chemical carcinogenesis - reactive oxygen species
KEGG:04714	0.0071582527241	0.375	SDHC SDHA SDHD	Thermogenesis
HP:0002027	0.00717720349197	0.5	SDHAF2 SDHA SDHD SDHC	Abdominal pain
HP:0003111	0.00728036426446	0.5	SDHAF2 SDHA SDHD SDHC	Abnormal blood ion concentration
HP:0002315	0.00792261538488	0.5	SDHAF2 SDHA SDHD SDHC	Headache
HP:0007700	0.00803360911744	0.5	SDHAF2 SDHA SDHD SDHC	Ocular anterior segment dysgenesis
HP:0003334	0.00812142628406	0.25	SDHC SDHD	Elevated circulating catecholamine level
HP:0012099	0.00812142628406	0.25	SDHC SDHD	Abnormality of circulating catecholamine level
HP:0003756	0.00812142628406	0.25	SDHD SDHA	Skeletal myopathy
HP:0011029	0.00872398029061	0.5	SDHAF2 SDHA SDHD SDHC	Internal hemorrhage
HP:0100659	0.00971174455567	0.5	SDHAF2 SDHA SDHD SDHC	Abnormal cerebral vascular morphology
HP:0011792	0.00997111818989	0.5	SDHAF2 SDHA SDHD SDHC	Neoplasm by histology
HP:0007272	0.0101490036868	0.25	SDHD SDHA	Progressive psychomotor deterioration
HP:0011028	0.0110602658548	0.5	SDHAF2 SDHA SDHD SDHC	Abnormality of blood circulation
KEGG:05012	0.0111289834178	0.375	SDHC SDHA SDHD	Parkinson disease
KEGG:05020	0.0121225246333	0.375	SDHC SDHA SDHD	Prion disease
HP:0008047	0.0131752265633	0.5	SDHAF2 SDHA SDHD SDHC	Abnormality of the vasculature of the eye
HP:0001824	0.0131752265633	0.5	SDHAF2 SDHA SDHD SDHC	Weight loss
HP:0001609	0.013356500578	0.375	SDHAF2 SDHD SDHC	Hoarse voice
GO:0006119	0.0137848137495	0.5	SDHAF2 SDHA SDHD SDHC	oxidative phosphorylation
GO:0005739	0.0144653996187	0.875	DHODH SDHAF2 SDHA SDHC SDHD SDHAF3 SDHAF4	mitochondrion
HP:0005595	0.014877056319	0.25	SDHC SDHD	Generalized hyperkeratosis
HP:0012817	0.014877056319	0.25	SDHD SDHA	Noncompaction cardiomyopathy
HP:0000822	0.0155758710774	0.5	SDHAF2 SDHA SDHD SDHC	Hypertension
KEGG:05016	0.0163151161285	0.375	SDHC SDHA SDHD	Huntington disease
GO:0006091	0.0164950268945	0.625	SDHAF2 SDHC SDHAF4 SDHD SDHA	generation of precursor metabolites and energy
HP:0000759	0.0168907213853	0.5	SDHAF2 SDHA SDHD SDHC	Abnormal peripheral nervous system morphology
HP:0003117	0.0172810254732	0.5	SDHAF2 SDHA SDHD SDHC	Abnormal circulating hormone concentration
REAC:R-HSA-1428517	0.0173433758996	0.375	SDHC SDHA SDHD	The citric acid (TCA) cycle and respiratory electron transport
HP:0008314	0.0175771621337	0.25	SDHD SDHA	Decreased activity of mitochondrial complex II
HP:0004390	0.0175771621337	0.25	SDHC SDHD	Hamartomatous polyposis
HP:0100834	0.0179343735586	0.375	SDHC SDHA SDHD	Neoplasm of the large intestine
HP:0006731	0.020501074829	0.25	SDHC SDHD	Follicular thyroid carcinoma
HP:0008675	0.020501074829	0.25	SDHC SDHD	Enlarged polycystic ovaries
HP:0040196	0.020501074829	0.25	SDHD SDHA	Mild microcephaly
HP:0032263	0.0265783442433	0.5	SDHAF2 SDHA SDHD SDHC	Increased blood pressure
HP:0001608	0.0265783442433	0.5	SDHAF2 SDHA SDHD SDHC	Abnormality of the voice
HP:0100879	0.0270195830756	0.25	SDHC SDHD	Enlarged ovaries
KEGG:05014	0.0275508352385	0.375	SDHC SDHA SDHD	Amyotrophic lateral sclerosis
HP:0002034	0.0278991450986	0.375	SDHC SDHA SDHD	Abnormal rectum morphology
HP:0000525	0.0279568393508	0.5	SDHAF2 SDHA SDHD SDHC	Abnormality iris morphology
HP:0012378	0.0288088693347	0.5	SDHAF2 SDHA SDHD SDHC	Fatigue
HP:5200230	0.0305702810662	0.5	SDHAF2 SDHA SDHD SDHC	Maladaptive fear-related cognitions
HP:0000739	0.0305702810662	0.5	SDHAF2 SDHA SDHD SDHC	Anxiety
HP:0011166	0.0306138099712	0.25	SDHD SDHA	Focal myoclonic seizure
HP:0031192	0.0306138099712	0.25	SDHD SDHA	Abnormal morphology of left ventricular trabeculae
HP:0030682	0.0306138099712	0.25	SDHD SDHA	Left ventricular noncompaction
HP:0007083	0.0306138099712	0.25	SDHD SDHA	Hyperactive patellar reflex
KEGG:05010	0.0317191137546	0.375	SDHC SDHA SDHD	Alzheimer disease
HP:0008056	0.0327243470758	0.5	SDHAF2 SDHA SDHD SDHC	Aplasia/Hypoplasia affecting the eye
HP:0030681	0.0344311064357	0.25	SDHD SDHA	Abnormal morphology of myocardial trabeculae
GO:0009060	0.0351826169143	0.5	SDHAF2 SDHA SDHD SDHC	aerobic respiration
HP:5200401	0.0356560220293	0.5	SDHAF2 SDHA SDHD SDHC	Abnormal judgment
HP:0002239	0.0375873282395	0.375	SDHC SDHA SDHD	Gastrointestinal hemorrhage
HP:0011675	0.0377152211096	0.5	SDHAF2 SDHA SDHD SDHC	Arrhythmia
GO:0008177	0.0393180950424	0.25	SDHD SDHA	succinate dehydrogenase (quinone) activity
GO:0000104	0.0393180950424	0.25	SDHD SDHA	succinate dehydrogenase activity
HP:0011343	0.0427341718023	0.25	SDHD SDHA	Moderate global developmental delay
HP:0030972	0.0436351567714	0.5	SDHAF2 SDHA SDHD SDHC	Abnormal systemic blood pressure
HP:0006801	0.0472195728067	0.25	SDHD SDHA	Hyperactive deep tendon reflexes
HP:0001892	0.0476665887161	0.5	SDHAF2 SDHA SDHD SDHC	Abnormal bleeding

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
SDHA	SDHB	0.999	0.924	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM bioplex3_HCT116 fraction boldt_WMM
SDHAF2	SDHA	0.999	0.088	mutually_exclusive (P21912) structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
DHODH	TMEM95	0.999			bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
SDHC	SDHD	0.998	0.922	mutually_exclusive (Q02127)	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
DHODH	SDHD	0.998	0.122	structurally_consistent (dimer)	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
SDHAF4	SDHA	0.997	0.07	mutually_exclusive (P21912)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction
SDHB	SDHAF3	0.997	0.046	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
SDHC	DHODH	0.987	0.086	structurally_consistent (dimer)	bioplex3_WMM bioplex3_HCT116 WMM_only
TMEM95	SDHD	0.977			bioplex3_HEK293 bioplex3_WMM WMM_only
SDHAF4	SDHAF3	0.972	0.104		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
SDHB	SDHD	0.97	0.974	structurally_consistent (dimer)	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
HGF	SDHB	0.961			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
SDHA	SDHD	0.944	0.786	structurally_consistent (P21912)	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
SDHB	SDHC	0.938	0.91	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction
SDHA	HGF	0.928			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
SDHAF2	SDHAF4	0.911	0.058		bioplex_WMM bioplex3_WMM WMM_only
SDHA	SDHC	0.859	0.804		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM fraction
SDHA	SDHAF3	0.832	0.104		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
SDHAF4	SDHB	0.732	0.062	structurally_consistent (dimer)	bioplex_WMM bioplex3_WMM WMM_only
SDHAF2	SDHB	0.728	0.09	mutually_exclusive (P31040) structurally_consistent (dimer)	bioplex_WMM bioplex3_WMM WMM_only
SDHAF2	SDHAF3	0.572	0.072		bioplex_WMM bioplex3_WMM WMM_only
SDHA	DHODH	0.255	0.088		bioplex3_WMM WMM_only
SDHB	DHODH	0.223	0.144		bioplex3_WMM WMM_only
SDHB	TMEM95	0.006			bioplex3_HEK293 bioplex3_HCT116 WMM_only
SDHA	TMEM95	0.002			bioplex3_HEK293 bioplex3_HCT116 WMM_only

Related Complexes

Genename	Complexes
SDHAF3	huMAP3_09045.1 huMAP3_12069.1 huMAP3_14997.1
SDHAF2	huMAP3_01061.1 huMAP3_04600.1 huMAP3_09045.1 huMAP3_12069.1 huMAP3_14997.1
HGF	huMAP3_03107.1 huMAP3_03927.1 huMAP3_12069.1
SDHAF4	huMAP3_01061.1 huMAP3_09045.1 huMAP3_12069.1 huMAP3_14997.1
SDHB	huMAP3_03107.1 huMAP3_12069.1
SDHA	huMAP3_01061.1 huMAP3_04600.1 huMAP3_09045.1 huMAP3_12069.1
SDHC	huMAP3_03912.1 huMAP3_03953.1 huMAP3_07875.1 huMAP3_12069.1
DHODH	huMAP3_03912.1 huMAP3_03953.1 huMAP3_12069.1
TMEM95	huMAP3_03912.1 huMAP3_12069.1
SDHD	huMAP3_03912.1 huMAP3_03953.1 huMAP3_12069.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_12069.1

Complex Portal: CPX-21203