hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_12073.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ACO2 | Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) | 5 | UniProt NCBI |
| FH | Fumarate hydratase, mitochondrial (Fumarase) (HsFH) (EC 4.2.1.2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP78 | 6.51224637934e-05 | 1.0 | FH ACO2 | TCA cycle aka Krebs or citric acid cycle |
| KEGG:00020 | 7.07178170959e-05 | 1.0 | FH ACO2 | Citrate cycle (TCA cycle) |
| WP:WP4290 | 0.000315397030529 | 1.0 | FH ACO2 | Metabolic reprogramming in colon cancer |
| REAC:R-HSA-71403 | 0.000358839967947 | 1.0 | FH ACO2 | Citric acid cycle (TCA cycle) |
| KEGG:01200 | 0.000870723283599 | 1.0 | FH ACO2 | Carbon metabolism |
| WP:WP3925 | 0.00144844277313 | 1.0 | FH ACO2 | Amino acid metabolism |
| REAC:R-HSA-71406 | 0.00226581808332 | 1.0 | FH ACO2 | Pyruvate metabolism and Citric Acid (TCA) cycle |
| HPA:0091063 | 0.00347720277717 | 1.0 | FH ACO2 | cerebellum; synaptic glomeruli - core[High] |
| HPA:0091003 | 0.00736964783823 | 1.0 | FH ACO2 | cerebellum; molecular layer cells - cytoplasm/membrane[High] |
| HPA:0090922 | 0.00765490123324 | 1.0 | FH ACO2 | cerebellum; GLUC cells - cytoplasm/membrane[>=Medium] |
| HPA:0090921 | 0.00916241126384 | 1.0 | FH ACO2 | cerebellum; GLUC cells - cytoplasm/membrane[>=Low] |
| HPA:0091072 | 0.010465910955 | 1.0 | FH ACO2 | cerebellum; white matter cells - cytoplasm/membrane[>=Medium] |
| HPA:0271112 | 0.010805326387 | 1.0 | FH ACO2 | kidney; bowman's capsule[>=Medium] |
| HPA:0091062 | 0.010805326387 | 1.0 | FH ACO2 | cerebellum; synaptic glomeruli - core[>=Medium] |
| HPA:0090991 | 0.0132065100286 | 1.0 | FH ACO2 | cerebellum; molecular layer - neuropil[>=Low] |
| HPA:0091071 | 0.0176947374969 | 1.0 | FH ACO2 | cerebellum; white matter cells - cytoplasm/membrane[>=Low] |
| HPA:0091061 | 0.0184319430009 | 1.0 | FH ACO2 | cerebellum; synaptic glomeruli - core[>=Low] |
| HPA:0271111 | 0.0185811895029 | 1.0 | FH ACO2 | kidney; bowman's capsule[>=Low] |
| HPA:0271123 | 0.0193364490193 | 1.0 | FH ACO2 | kidney; collecting ducts[High] |
| HPA:0271143 | 0.019796826334 | 1.0 | FH ACO2 | kidney; proximal tubules (cell body)[High] |
| HPA:0091002 | 0.0205761578668 | 1.0 | FH ACO2 | cerebellum; molecular layer cells - cytoplasm/membrane[>=Medium] |
| REAC:R-HSA-1428517 | 0.0242575818332 | 1.0 | FH ACO2 | The citric acid (TCA) cycle and respiratory electron transport |
| HPA:0271133 | 0.0245263757673 | 1.0 | FH ACO2 | kidney; distal tubules[High] |
| HPA:0091001 | 0.0253929683598 | 1.0 | FH ACO2 | cerebellum; molecular layer cells - cytoplasm/membrane[>=Low] |
| HPA:0090942 | 0.0295730740175 | 1.0 | FH ACO2 | cerebellum; Purkinje cells - cytoplasm/membrane[>=Medium] |
| WP:WP4966 | 0.0373151717536 | 0.5 | ACO2 | Fluoroacetic acid toxicity |
| HPA:0090941 | 0.0433356476262 | 1.0 | FH ACO2 | cerebellum; Purkinje cells - cytoplasm/membrane[>=Low] |
| HP:0003536 | 0.0499436884913 | 0.5 | FH | Decreased fumarate hydratase activity |
| HP:0006732 | 0.0499436884913 | 0.5 | FH | Papillary renal cell carcinoma type 2 |
| HP:0007437 | 0.0499436884913 | 0.5 | FH | Multiple cutaneous leiomyomas |
| HP:0034648 | 0.0499436884913 | 0.5 | FH | Elevated urine fumaric acid level |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ACO2 | FH | 0.933 | 0.434 | bioplex_WMM Guru bioplex3_WMM fraction |
Related Complexes
| Genename | Complexes |
|---|---|
| ACO2 | huMAP3_12073.1 huMAP3_12238.1 |
| FH | huMAP3_12073.1 |