hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_12077.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MICAL2 | [F-actin]-monooxygenase MICAL2 (EC 1.14.13.225) (MICAL C-terminal-like protein) (Mical-cL) (Molecule interacting with CasL protein 2) (MICAL-2) | 5 | UniProt NCBI |
| PCDHB13 | Protocadherin beta-13 (PCDH-beta-13) | 4 | UniProt NCBI |
| SH2D1B | SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2) | 5 | UniProt NCBI |
| ROR1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 (Neurotrophic tyrosine kinase, receptor-related 1) | 5 | UniProt NCBI |
| SEMA7A | Semaphorin-7A (CDw108) (JMH blood group antigen) (John-Milton-Hargen human blood group Ag) (Semaphorin-K1) (Sema K1) (Semaphorin-L) (Sema L) (CD antigen CD108) | 5 | UniProt NCBI |
| SIRPA | Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a) | 5 | UniProt NCBI |
| SIRPB1 | Signal-regulatory protein beta-1 isoform 3 (SIRP-beta-1 isoform 3) | 4 | UniProt NCBI |
| SIRPG | Signal-regulatory protein gamma (SIRP-gamma) (CD172 antigen-like family member B) (Signal-regulatory protein beta-2) (SIRP-b2) (SIRP-beta-2) (CD antigen CD172g) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-391160 | 3.77160472982e-06 | 0.375 | SIRPB1 SIRPA SIRPG | Signal regulatory protein family interactions |
| KEGG:04380 | 0.00127849680123 | 0.375 | SIRPB1 SIRPA SIRPG | Osteoclast differentiation |
| KEGG:04148 | 0.00160212912447 | 0.375 | SIRPB1 SIRPA SIRPG | Efferocytosis |
| REAC:R-HSA-1500931 | 0.00394796923331 | 0.375 | SIRPB1 SIRPA SIRPG | Cell-Cell communication |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SIRPG | SIRPA | 0.991 | 0.166 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| SIRPA | SIRPB1 | 0.99 | 0.382 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| SIRPA | SH2D1B | 0.981 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ROR1 | SIRPA | 0.905 | 0.096 | bioplex3_WMM WMM_only |
| ROR1 | PCDHB13 | 0.904 | bioplex3_WMM WMM_only | |
| PCDHB13 | SIRPA | 0.904 | bioplex3_WMM WMM_only | |
| PCDHB13 | SEMA7A | 0.883 | bioplex3_WMM WMM_only | |
| SEMA7A | SIRPA | 0.881 | 0.054 | bioplex3_WMM WMM_only |
| ROR1 | SEMA7A | 0.881 | 0.054 | bioplex3_WMM WMM_only |
| MICAL2 | SEMA7A | 0.869 | bioplex3_WMM WMM_only |
Related Complexes