hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12079.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PPP6R2 | Serine/threonine-protein phosphatase 6 regulatory subunit 2 (SAPS domain family member 2) | 5 | UniProt NCBI |
| BORA | Protein aurora borealis (HsBora) | 5 | UniProt NCBI |
| ANKRD28 | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK) | 5 | UniProt NCBI |
| PLK1 | Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13) | 5 | UniProt NCBI |
| SPART | Spartin (Spastic paraplegia 20 protein) (Trans-activated by hepatitis C virus core protein 1) | 5 | UniProt NCBI |
| RNASEL | 2-5A-dependent ribonuclease (2-5A-dependent RNase) (EC 3.1.26.-) (Ribonuclease 4) (Ribonuclease L) (RNase L) | 5 | UniProt NCBI |
| PPP6R3 | Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL) | 5 | UniProt NCBI |
| ANKRD52 | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) (Ankyrin repeat domain-containing protein 52) | 3 | UniProt NCBI |
| PPP6C | Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC 3.1.3.16) [Cleaved into: Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed] | 5 | UniProt NCBI |
| ANKRD44 | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) | 4 | UniProt NCBI |
| PPP6R1 | Serine/threonine-protein phosphatase 6 regulatory subunit 1 (SAPS domain family member 1) | 5 | UniProt NCBI |
| MRNIP | MRN complex-interacting protein (MRN-interacting protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5196 | 7.81592632804e-09 | 0.333333333333 | PPP6R1 PPP6C PPP6R2 ANKRD28 | TNF-alpha/NF-kappa B signaling complex (CHUK, BTRC, NFKB2, PPP6C, REL, CUL1, IKBKE, SAPS2, SAPS1, ANKRD28, RELA, SKP1) |
| REAC:R-HSA-204005 | 3.60283278994e-05 | 0.333333333333 | PPP6R1 PPP6C ANKRD28 PPP6R3 | COPII-mediated vesicle transport |
| REAC:R-HSA-171319 | 0.000201661544655 | 0.25 | PPP6C ANKRD28 PPP6R3 | Telomere Extension By Telomerase |
| REAC:R-HSA-199977 | 0.00111222618202 | 0.333333333333 | PPP6R1 PPP6C ANKRD28 PPP6R3 | ER to Golgi Anterograde Transport |
| REAC:R-HSA-948021 | 0.00231489399677 | 0.333333333333 | PPP6R1 PPP6C ANKRD28 PPP6R3 | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-180786 | 0.002340810935 | 0.25 | PPP6C ANKRD28 PPP6R3 | Extension of Telomeres |
| REAC:R-HSA-446203 | 0.016378269356 | 0.333333333333 | PPP6R1 PPP6C ANKRD28 PPP6R3 | Asparagine N-linked glycosylation |
| REAC:R-HSA-157579 | 0.0177681329322 | 0.25 | PPP6C ANKRD28 PPP6R3 | Telomere Maintenance |
| REAC:R-HSA-1640170 | 0.0277921617981 | 0.416666666667 | PLK1 PPP6C PPP6R3 BORA ANKRD28 | Cell Cycle |
| REAC:R-HSA-73886 | 0.0361770100275 | 0.25 | PPP6C ANKRD28 PPP6R3 | Chromosome Maintenance |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| ANKRD28 | PPP6C | 1.0 | 0.156 |
| ANKRD52 | PPP6C | 1.0 | 0.054 |
| PPP6C | PPP6R1 | 1.0 | 0.26 |
| PPP6C | ANKRD44 | 1.0 | 0.094 |
| ANKRD28 | ANKRD44 | 1.0 | 0.256 |
| PPP6R2 | PPP6C | 1.0 | 0.082 |
| PPP6R3 | PPP6C | 1.0 | 0.444 |
| PPP6R2 | ANKRD44 | 1.0 | 0.126 |
| ANKRD44 | PPP6R1 | 1.0 | 0.018 |
| PPP6R2 | ANKRD28 | 1.0 | 0.092 |
| ANKRD52 | PPP6R2 | 0.999 | 0.088 |
| ANKRD52 | ANKRD28 | 0.999 | 0.046 |
| PPP6R2 | PPP6R3 | 0.999 | 0.084 |
| PPP6R2 | PLK1 | 0.999 | 0.036 |
| PPP6R3 | ANKRD44 | 0.999 | 0.02 |
| ANKRD52 | PPP6R1 | 0.999 | 0.046 |
| ANKRD28 | PPP6R3 | 0.999 | 0.176 |
| PPP6R2 | PPP6R1 | 0.998 | 0.042 |
| ANKRD52 | ANKRD44 | 0.998 | 0.066 |
| PPP6R3 | PPP6R1 | 0.997 | 0.09 |
| ANKRD28 | PPP6R1 | 0.997 | 0.112 |
| ANKRD52 | PPP6R3 | 0.996 | 0.118 |
| BORA | PLK1 | 0.993 | |
| ANKRD44 | SPART | 0.987 | 0.026 |
| ANKRD44 | MRNIP | 0.983 | 0.0812 |
| ANKRD28 | PLK1 | 0.971 | 0.104 |
| PPP6R1 | SPART | 0.945 | 0.028 |
| PPP6R2 | BORA | 0.901 | |
| PPP6C | PLK1 | 0.897 | 0.166 |
| RNASEL | ANKRD52 | 0.874 | 0.054 |
| PPP6C | SPART | 0.755 | 0.058 |
| ANKRD44 | PLK1 | 0.357 | 0.086 |
| ANKRD52 | PLK1 | 0.2 | 0.264322033898 |
| ANKRD28 | SPART | 0.199 | 0.036 |
| PPP6R3 | BORA | 0.191 | |
| ANKRD52 | SPART | 0.18 | 0.052 |
| PPP6R2 | MRNIP | 0.175 | 0.074 |
| ANKRD28 | MRNIP | 0.102 | 0.208 |
| PPP6R1 | MRNIP | 0.102 | 0.158 |
| PPP6R1 | BORA | 0.084 | |
| ANKRD28 | BORA | 0.083 | |
| PPP6R3 | MRNIP | 0.068 | 0.14 |
| PPP6C | BORA | 0.067 | |
| RNASEL | SPART | 0.063 | 0.094 |
| PPP6R3 | SPART | 0.054 | 0.048 |
| RNASEL | PPP6R1 | 0.051 | 0.054 |
| PPP6R1 | PLK1 | 0.036 | 0.144145299145 |
| RNASEL | BORA | 0.032 | |
| ANKRD52 | MRNIP | 0.027 | 0.08 |
| ANKRD52 | BORA | 0.023 | |
| RNASEL | PPP6C | 0.019 | 0.192 |
| PPP6C | MRNIP | 0.018 | 0.108 |
| ANKRD44 | BORA | 0.017 | |
| RNASEL | ANKRD28 | 0.017 | 0.068 |
| SPART | BORA | 0.015 | |
| RNASEL | PPP6R2 | 0.015 | 0.082 |
| RNASEL | PPP6R3 | 0.011 | 0.086 |
| MRNIP | SPART | 0.008 | 0.106 |
| SPART | PLK1 | 0.006 | 0.078 |
| MRNIP | PLK1 | 0.006 | 0.132448275862 |
| PPP6R3 | PLK1 | 0.003 | 0.308 |
| PPP6R2 | SPART | 0.002 | 0.042 |
Related Complexes