hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12088.1
Complex Portal: CPX-23846
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SOX17 | Transcription factor SOX-17 | 5 | UniProt NCBI |
| FRY | Protein furry homolog | 5 | UniProt NCBI |
| HOMER1 | Homer protein homolog 1 (Homer-1) | 5 | UniProt NCBI |
| CEP192 | Centrosomal protein of 192 kDa (Cep192) (Cep192/SPD-2) | 5 | UniProt NCBI |
| HOMER2 | Homer protein homolog 2 (Homer-2) (Cupidin) | 5 | UniProt NCBI |
| HOMER3 | Homer protein homolog 3 (Homer-3) | 5 | UniProt NCBI |
| TRAF5 | TNF receptor-associated factor 5 (RING finger protein 84) | 5 | UniProt NCBI |
| MYPN | Myopalladin (145 kDa sarcomeric protein) | 5 | UniProt NCBI |
| FRYL | Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5417 | 1.25617164419e-05 | 0.444444444444 | SOX17 HOMER2 HOMER3 HOMER1 | Cell lineage map for neuronal differentiation |
| GO:0007216 | 0.000161332517231 | 0.333333333333 | HOMER1 HOMER3 HOMER2 | G protein-coupled glutamate receptor signaling pathway |
| GO:2001256 | 0.000161332517231 | 0.333333333333 | HOMER1 HOMER3 HOMER2 | regulation of store-operated calcium entry |
| GO:0035256 | 0.000282244947588 | 0.333333333333 | HOMER1 HOMER3 HOMER2 | G protein-coupled glutamate receptor binding |
| REAC:R-HSA-6794361 | 0.000573226646465 | 0.333333333333 | HOMER1 HOMER3 HOMER2 | Neurexins and neuroligins |
| KEGG:04724 | 0.000679986209508 | 0.333333333333 | HOMER1 HOMER3 HOMER2 | Glutamatergic synapse |
| GO:0002115 | 0.000966803032193 | 0.333333333333 | HOMER1 HOMER3 HOMER2 | store-operated calcium entry |
| KEGG:04068 | 0.00184766477855 | 0.333333333333 | HOMER1 HOMER3 HOMER2 | FoxO signaling pathway |
| REAC:R-HSA-6794362 | 0.00205183750398 | 0.333333333333 | HOMER1 HOMER3 HOMER2 | Protein-protein interactions at synapses |
| GO:0035254 | 0.00546674693619 | 0.333333333333 | HOMER1 HOMER3 HOMER2 | glutamate receptor binding |
| GO:0007215 | 0.020844368733 | 0.333333333333 | HOMER1 HOMER3 HOMER2 | glutamate receptor signaling pathway |
| WP:WP5420 | 0.0398484415758 | 0.333333333333 | HOMER1 HOMER3 HOMER2 | ADHD and autism ASD linked metabolic pathways and SNP |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| HOMER3 | HOMER1 | 1.0 | 0.048 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| HOMER2 | HOMER1 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| HOMER3 | HOMER2 | 0.998 |
mutually_exclusive (Q6IQ16)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| FRYL | HOMER3 | 0.997 | 0.052 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| FRY | FRYL | 0.99 | 0.066 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TRAF5 | HOMER1 | 0.973 | 0.122 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| FRYL | HOMER1 | 0.96 | 0.108 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () | |
| HOMER1 | MYPN | 0.923 | 0.0500418848168 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| HOMER2 | MYPN | 0.903 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| CEP192 | HOMER3 | 0.866 | 0.12 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| HOMER3 | SOX17 | 0.837 | hein_WMM hein () | ||
| HOMER3 | MYPN | 0.781 | 0.032 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| TRAF5 | HOMER3 | 0.358 | 0.082 | bioplex_WMM bioplex3_WMM WMM_only | |
| TRAF5 | HOMER2 | 0.215 | bioplex_WMM bioplex3_WMM WMM_only | ||
| FRYL | HOMER2 | 0.193 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CEP192 | HOMER2 | 0.187 | bioplex_WMM bioplex3_WMM WMM_only | ||
| FRY | HOMER3 | 0.178 | 0.058 | bioplex_WMM bioplex3_WMM WMM_only | |
| FRY | HOMER1 | 0.164 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only | |
| CEP192 | HOMER1 | 0.106 | 0.15 | bioplex_WMM bioplex3_WMM WMM_only | |
| TRAF5 | CEP192 | 0.04 | 0.22 | youn_WMM gupta_WMM WMM_only | |
| CEP192 | FRYL | 0.018 | 0.202 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
Related Complexes