hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_12089.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| B3GAT3 | Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (EC 2.4.1.135) (Beta-1,3-glucuronyltransferase 3) (Glucuronosyltransferase I) (GlcAT-I) (UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase) (GlcUAT-I) | 5 | UniProt NCBI |
| NDST4 | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 (EC 2.8.2.8) (Glucosaminyl N-deacetylase/N-sulfotransferase 4) (NDST-4) (N-heparan sulfate sulfotransferase 4) (N-HSST 4) [Includes: Heparan sulfate N-deacetylase 4 (EC 3.-.-.-); Heparan sulfate N-sulfotransferase 4 (EC 2.8.2.-)] | 5 | UniProt NCBI |
| NDST3 | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 (Glucosaminyl N-deacetylase/N-sulfotransferase 3) (NDST-3) (hNDST-3) (N-heparan sulfate sulfotransferase 3) (N-HSST 3) [Includes: Heparan sulfate N-deacetylase NDST3 (EC 3.-.-.-); [heparan sulfate]-glucosamine N-sulfotransferase NDST3 (EC 2.8.2.8)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00534 | 6.94780731694e-08 | 1.0 | B3GAT3 NDST4 NDST3 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin |
| WP:WP5395 | 6.53926343968e-07 | 1.0 | B3GAT3 NDST4 NDST3 | Glycosaminoglycan synthesis in fibroblasts |
| REAC:R-HSA-1638091 | 9.1454019665e-06 | 1.0 | B3GAT3 NDST4 NDST3 | Heparan sulfate/heparin (HS-GAG) metabolism |
| REAC:R-HSA-1630316 | 0.000100702074103 | 1.0 | B3GAT3 NDST4 NDST3 | Glycosaminoglycan metabolism |
| GO:0015012 | 0.000221076094476 | 1.0 | B3GAT3 NDST4 NDST3 | heparan sulfate proteoglycan biosynthetic process |
| REAC:R-HSA-71387 | 0.0012894643491 | 1.0 | B3GAT3 NDST4 NDST3 | Metabolism of carbohydrates |
| GO:0030166 | 0.00200169985542 | 1.0 | B3GAT3 NDST4 NDST3 | proteoglycan biosynthetic process |
| REAC:R-HSA-2022928 | 0.00257431960226 | 0.666666666667 | NDST4 NDST3 | HS-GAG biosynthesis |
| GO:0006029 | 0.00345936027834 | 1.0 | B3GAT3 NDST4 NDST3 | proteoglycan metabolic process |
| GO:0015016 | 0.00842684400117 | 0.666666666667 | NDST4 NDST3 | [heparan sulfate]-glucosamine N-sulfotransferase activity |
| WP:WP702 | 0.0101834993772 | 0.666666666667 | NDST4 NDST3 | Metapathway biotransformation Phase I and II |
| KEGG:01100 | 0.0189521995452 | 1.0 | B3GAT3 NDST4 NDST3 | Metabolic pathways |
| GO:0044272 | 0.0351938724399 | 1.0 | B3GAT3 NDST4 NDST3 | sulfur compound biosynthetic process |
| GO:0015014 | 0.0393180950424 | 0.666666666667 | NDST4 NDST3 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NDST3 | NDST4 | 0.985 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| B3GAT3 | NDST3 | 0.813 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| B3GAT3 | NDST4 | 0.295 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| B3GAT3 | huMAP3_01775.1 huMAP3_10314.1 huMAP3_12089.1 |
| NDST4 | huMAP3_04095.1 huMAP3_05511.1 huMAP3_12089.1 huMAP3_12113.1 huMAP3_14123.1 |
| NDST3 | huMAP3_04095.1 huMAP3_05511.1 huMAP3_07022.1 huMAP3_12089.1 huMAP3_12113.1 huMAP3_14123.1 |