hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12091.1
Complex Portal: CPX-18657
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| IMPA2 | Inositol monophosphatase 2 (IMP 2) (IMPase 2) (EC 3.1.3.25) (Inositol-1(or 4)-monophosphatase 2) (Myo-inositol monophosphatase A2) | 5 | UniProt NCBI |
| CTSH | Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H (EC 3.4.22.16); Cathepsin H heavy chain; Cathepsin H light chain] | 5 | UniProt NCBI |
| RNASE7 | Ribonuclease 7 (RNase 7) (EC 3.1.27.-) (Skin-derived antimicrobial protein 2) (SAP-2) | 5 | UniProt NCBI |
| ALOXE3 | Hydroperoxide isomerase ALOXE3 (Epidermis-type lipoxygenase 3) (Epidermal LOX-3) (e-LOX-3) (eLOX-3) (Hydroperoxy dehydratase ALOXE3) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) (Hydroperoxy icosatetraenoate isomerase) (EC 5.4.4.7) | 5 | UniProt NCBI |
| PSAPL1 | Proactivator polypeptide-like 1 [Cleaved into: Saposin A-like; Saposin B-Val-like; Saposin B-like; Saposin C-like; Saposin D-like] | 4 | UniProt NCBI |
| PLK2 | Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 2) (PLK-2) (hPlk2) (Serine/threonine-protein kinase SNK) (hSNK) (Serum-inducible kinase) | 5 | UniProt NCBI |
| APTX | Aprataxin (EC 3.6.1.71) (EC 3.6.1.72) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT) | 5 | UniProt NCBI |
| THAP10 | THAP domain-containing protein 10 | 4 | UniProt NCBI |
| SLCO6A1 | Solute carrier organic anion transporter family member 6A1 (Cancer/testis antigen 48) (CT48) (Gonad-specific transporter) (GST) (Organic anion-transporting polypeptide 6A1) (Organic anion-transporting polypeptide I) (OATP-I) (Solute carrier family 21 member 19) | 5 | UniProt NCBI |
| GDPD3 | Lysophospholipase D GDPD3 (EC 3.1.4.-) (Glycerophosphodiester phosphodiesterase 7) (Glycerophosphodiester phosphodiesterase domain-containing protein 3) | 5 | UniProt NCBI |
| ZIC1 | Zinc finger protein ZIC 1 (Zinc finger protein 201) (Zinc finger protein of the cerebellum 1) | 5 | UniProt NCBI |
| IFNA4 | Interferon alpha-4 (IFN-alpha-4) (Interferon alpha-4B) (Interferon alpha-76) (Interferon alpha-M1) | 5 | UniProt NCBI |
| SDR9C7 | Short-chain dehydrogenase/reductase family 9C member 7 (EC 1.1.1.-) (Orphan short-chain dehydrogenase/reductase) (SDR-O) (RDH-S) | 4 | UniProt NCBI |
| AIRE | Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein) (APECED protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0000491 | 0.0463584137203 | 0.214285714286 | ALOXE3 SDR9C7 AIRE | Keratitis |
| CORUM:1985 | 0.0499958217778 | 0.0714285714286 | AIRE | AIRE homodimer complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ALOXE3 | IFNA4 | 0.985 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CTSH | ZIC1 | 0.984 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PSAPL1 | IFNA4 | 0.984 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| RNASE7 | SLCO6A1 | 0.982 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| RNASE7 | ZIC1 | 0.982 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SDR9C7 | ZIC1 | 0.982 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ALOXE3 | THAP10 | 0.98 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SDR9C7 | IMPA2 | 0.976 | bioplex_WMM bioplex3_WMM WMM_only | ||
| AIRE | CTSH | 0.975 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| CTSH | GDPD3 | 0.973 | 0.176 | bioplex_WMM bioplex3_WMM WMM_only | |
| RNASE7 | THAP10 | 0.966 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RNASE7 | GDPD3 | 0.961 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CTSH | RNASE7 | 0.956 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ZIC1 | IMPA2 | 0.941 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| GDPD3 | ZIC1 | 0.939 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| RNASE7 | SDR9C7 | 0.915 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CTSH | APTX | 0.913 | 0.048 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CTSH | SLCO6A1 | 0.901 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| APTX | IMPA2 | 0.897 | 0.102 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| AIRE | GDPD3 | 0.893 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SDR9C7 | IFNA4 | 0.882 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GDPD3 | SDR9C7 | 0.879 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SDR9C7 | ALOXE3 | 0.864 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CTSH | IFNA4 | 0.851 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| RNASE7 | ALOXE3 | 0.849 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | ||
| PSAPL1 | CTSH | 0.849 | bioplex3_WMM WMM_only | ||
| CTSH | SDR9C7 | 0.842 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PSAPL1 | RNASE7 | 0.836 | bioplex3_WMM WMM_only | ||
| PSAPL1 | SDR9C7 | 0.817 | bioplex3_WMM fraction | ||
| APTX | RNASE7 | 0.807 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| RNASE7 | IFNA4 | 0.802 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RNASE7 | PLK2 | 0.802 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| APTX | SDR9C7 | 0.795 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GDPD3 | IMPA2 | 0.779 | 0.098 | bioplex_WMM bioplex3_WMM WMM_only | |
| CTSH | IMPA2 | 0.685 | 0.12 | bioplex_WMM bioplex3_WMM WMM_only | |
| SDR9C7 | PLK2 | 0.647 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| RNASE7 | IMPA2 | 0.619 | bioplex_WMM bioplex3_WMM WMM_only | ||
| AIRE | SDR9C7 | 0.474 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ALOXE3 | PLK2 | 0.404 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PSAPL1 | GDPD3 | 0.384 | bioplex3_WMM WMM_only | ||
| ALOXE3 | ZIC1 | 0.372 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PSAPL1 | IMPA2 | 0.265 | bioplex3_WMM WMM_only | ||
| CTSH | ALOXE3 | 0.183 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PSAPL1 | ALOXE3 | 0.153 | bioplex3_WMM WMM_only | ||
| ALOXE3 | IMPA2 | 0.134 | bioplex_WMM bioplex3_WMM WMM_only | ||
| GDPD3 | ALOXE3 | 0.134 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes