hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12094.1
Complex Portal: CPX-19049
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HS3ST6 | Heparan sulfate glucosamine 3-O-sulfotransferase 6 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 6) (3-OST-6) (Heparan sulfate 3-O-sulfotransferase 6) (h3-OST-6) | 5 | UniProt NCBI |
| NRM | Nurim (Nuclear envelope membrane protein) (Nuclear rim protein) | 5 | UniProt NCBI |
| HS3ST2 | Heparan sulfate glucosamine 3-O-sulfotransferase 2 (EC 2.8.2.29) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2) (3-OST-2) (Heparan sulfate 3-O-sulfotransferase 2) (h3-OST-2) | 5 | UniProt NCBI |
| HS3ST4 | Heparan sulfate glucosamine 3-O-sulfotransferase 4 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4) (3-OST-4) (Heparan sulfate 3-O-sulfotransferase 4) (h3-OST-4) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0008467 | 3.84440695359e-06 | 0.75 | HS3ST2 HS3ST6 HS3ST4 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity |
| REAC:R-HSA-2022928 | 4.59102468944e-06 | 0.75 | HS3ST2 HS3ST6 HS3ST4 | HS-GAG biosynthesis |
| REAC:R-HSA-1638091 | 2.7436612495e-05 | 0.75 | HS3ST2 HS3ST6 HS3ST4 | Heparan sulfate/heparin (HS-GAG) metabolism |
| GO:0034483 | 0.000109904886398 | 0.75 | HS3ST2 HS3ST6 HS3ST4 | heparan sulfate sulfotransferase activity |
| GO:0030201 | 0.000109904886398 | 0.75 | HS3ST2 HS3ST6 HS3ST4 | heparan sulfate proteoglycan metabolic process |
| WP:WP702 | 0.000139209137611 | 0.75 | HS3ST2 HS3ST6 HS3ST4 | Metapathway biotransformation Phase I and II |
| REAC:R-HSA-1630316 | 0.000301178051097 | 0.75 | HS3ST2 HS3ST6 HS3ST4 | Glycosaminoglycan metabolism |
| GO:0008146 | 0.0037914498893 | 0.75 | HS3ST2 HS3ST6 HS3ST4 | sulfotransferase activity |
| REAC:R-HSA-71387 | 0.00382744839761 | 0.75 | HS3ST2 HS3ST6 HS3ST4 | Metabolism of carbohydrates |
| GO:0016782 | 0.0100599149475 | 0.75 | HS3ST2 HS3ST6 HS3ST4 | transferase activity, transferring sulphur-containing groups |
| GO:0006029 | 0.0137962469792 | 0.75 | HS3ST2 HS3ST6 HS3ST4 | proteoglycan metabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| HS3ST2 | HS3ST4 | 0.986 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| NRM | HS3ST2 | 0.975 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| HS3ST2 | HS3ST6 | 0.908 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| HS3ST6 | huMAP3_11760.1 huMAP3_12094.1 |
| NRM | huMAP3_02857.1 huMAP3_10176.1 huMAP3_12094.1 |
| HS3ST2 | huMAP3_02857.1 huMAP3_03539.1 huMAP3_08299.1 huMAP3_11760.1 huMAP3_12094.1 |
| HS3ST4 | huMAP3_03326.1 huMAP3_03539.1 huMAP3_08299.1 huMAP3_10878.1 huMAP3_11760.1 huMAP3_12094.1 |