hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12096.1
Complex Portal: CPX-15359
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| JAK2 | Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2) | 5 | UniProt NCBI |
| ADIRF | Adipogenesis regulatory factor (Adipogenesis factor rich in obesity) (Adipose most abundant gene transcript 2 protein) (Adipose-specific protein 2) (apM-2) | 4 | UniProt NCBI |
| ARHGAP18 | Rho GTPase-activating protein 18 (MacGAP) (Rho-type GTPase-activating protein 18) | 5 | UniProt NCBI |
| NRAS | GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras) | 5 | UniProt NCBI |
| SERINC2 | Serine incorporator 2 (Tumor differentially expressed protein 2-like) | 3 | UniProt NCBI |
| ANXA11 | Annexin A11 (56 kDa autoantigen) (Annexin XI) (Annexin-11) (Calcyclin-associated annexin 50) (CAP-50) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9027284 | 0.00116019984728 | 0.333333333333 | NRAS JAK2 | Erythropoietin activates RAS |
| REAC:R-HSA-9669938 | 0.0035019037522 | 0.333333333333 | NRAS JAK2 | Signaling by KIT in disease |
| REAC:R-HSA-9670439 | 0.0035019037522 | 0.333333333333 | NRAS JAK2 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants |
| WP:WP5358 | 0.00407076266464 | 0.333333333333 | NRAS JAK2 | JAK STAT signaling in the regulation of Beta cells |
| REAC:R-HSA-9006335 | 0.00440152140132 | 0.333333333333 | NRAS JAK2 | Signaling by Erythropoietin |
| REAC:R-HSA-5673000 | 0.0111743831709 | 0.333333333333 | NRAS JAK2 | RAF activation |
| KEGG:04917 | 0.0135980974704 | 0.333333333333 | NRAS JAK2 | Prolactin signaling pathway |
| REAC:R-HSA-9656223 | 0.0152705482636 | 0.333333333333 | NRAS JAK2 | Signaling by RAF1 mutants |
| REAC:R-HSA-1433557 | 0.0161658624528 | 0.333333333333 | NRAS JAK2 | Signaling by SCF-KIT |
| REAC:R-HSA-6802949 | 0.0180324600743 | 0.333333333333 | NRAS JAK2 | Signaling by RAS mutants |
| REAC:R-HSA-9649948 | 0.0180324600743 | 0.333333333333 | NRAS JAK2 | Signaling downstream of RAS mutants |
| REAC:R-HSA-6802955 | 0.0180324600743 | 0.333333333333 | NRAS JAK2 | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| REAC:R-HSA-6802946 | 0.0180324600743 | 0.333333333333 | NRAS JAK2 | Signaling by moderate kinase activity BRAF mutants |
| KEGG:01521 | 0.0193802025824 | 0.333333333333 | NRAS JAK2 | EGFR tyrosine kinase inhibitor resistance |
| KEGG:05235 | 0.0226487502466 | 0.333333333333 | NRAS JAK2 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| KEGG:04933 | 0.0267786555833 | 0.333333333333 | NRAS JAK2 | AGE-RAGE signaling pathway in diabetic complications |
| KEGG:04725 | 0.0280210779884 | 0.333333333333 | NRAS JAK2 | Cholinergic synapse |
| WP:WP4806 | 0.0306106562527 | 0.333333333333 | NRAS JAK2 | EGFR tyrosine kinase inhibitor resistance |
| KEGG:04935 | 0.0353486809432 | 0.333333333333 | NRAS JAK2 | Growth hormone synthesis, secretion and action |
| REAC:R-HSA-6802952 | 0.0393724000146 | 0.333333333333 | NRAS JAK2 | Signaling by BRAF and RAF1 fusions |
| HPA:0100202 | 0.0419105921912 | 0.833333333333 | ADIRF SERINC2 ANXA11 JAK2 ARHGAP18 | cerebral cortex; endothelial cells[>=Medium] |
| CORUM:2028 | 0.0499436884912 | 0.166666666667 | JAK2 | JAK2-IL12RB2 complex |
| CORUM:5178 | 0.0499436884912 | 0.166666666667 | JAK2 | JAK2-PAFR-TYK2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SERINC2 | NRAS | 0.987 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ARHGAP18 | JAK2 | 0.946 | 0.390647058824 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| SERINC2 | ADIRF | 0.865 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NRAS | ANXA11 | 0.822 | 0.222 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| SERINC2 | ARHGAP18 | 0.819 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NRAS | ADIRF | 0.1 | 0.420048799027 | bioplex3_WMM WMM_only | |
| ARHGAP18 | ADIRF | 0.073 | 0.096 | bioplex3_WMM WMM_only | |
| NRAS | ARHGAP18 | 0.048 | 0.274 | bioplex3_WMM WMM_only | |
| ARHGAP18 | ANXA11 | 0.013 | 0.042 | bioplex3_WMM WMM_only | |
| ADIRF | ANXA11 | 0.011 | 0.036 | bioplex3_WMM WMM_only | |
| SERINC2 | ANXA11 | 0.006 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 |
Related Complexes