hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_12098.1

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
GBP5	Guanylate-binding protein 5 (EC 3.6.5.-) (GBP-TA antigen) (GTP-binding protein 5) (GBP-5) (Guanine nucleotide-binding protein 5)	5	UniProt NCBI
GBP2	Guanylate-binding protein 2 (EC 3.6.5.-) (GTP-binding protein 2) (GBP-2) (HuGBP-2) (Guanine nucleotide-binding protein 2) (Interferon-induced guanylate-binding protein 2)	5	UniProt NCBI
GBP3	Guanylate-binding protein 3 (EC 3.6.5.-) (GTP-binding protein 3) (GBP-3) (Guanine nucleotide-binding protein 3)	5	UniProt NCBI
GBP1	Guanylate-binding protein 1 (EC 3.6.1.-) (EC 3.6.5.-) (GTP-binding protein 1) (GBP-1) (HuGBP-1) (hGBP1) (Guanine nucleotide-binding protein 1) (Interferon-induced guanylate-binding protein 1)	5	UniProt NCBI
CASP6	Caspase-6 (CASP-6) (CSP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18 (Caspase-6 subunit p20); Caspase-6 subunit p11 (Caspase-6 subunit p10)]	5	UniProt NCBI
GBP7	Guanylate-binding protein 7 (EC 3.6.1.-) (EC 3.6.5.-) (GTP-binding protein 7) (GBP-7) (Guanine nucleotide-binding protein 7) (Guanylate-binding protein 4-like)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0051715	3.2413958192e-13	0.833333333333	GBP1 GBP5 GBP7 GBP3 GBP2	cytolysis in another organism
GO:0019835	1.13442382344e-12	0.833333333333	GBP1 GBP5 GBP7 GBP3 GBP2	cytolysis
GO:0070269	1.42135021777e-09	0.833333333333	GBP1 GBP5 CASP6 GBP3 GBP2	pyroptosis
GO:0140639	1.97323122031e-09	0.666666666667	GBP1 GBP5 GBP3 GBP2	positive regulation of pyroptosis
REAC:R-HSA-877300	3.65472767355e-09	0.833333333333	GBP1 GBP5 GBP7 GBP3 GBP2	Interferon gamma signaling
KEGG:04621	2.86185774302e-08	0.833333333333	GBP1 GBP5 GBP7 GBP3 GBP2	NOD-like receptor signaling pathway
GO:0031640	4.58614910437e-08	0.833333333333	GBP1 GBP5 GBP7 GBP3 GBP2	killing of cells of another organism
GO:0141061	4.58614910437e-08	0.833333333333	GBP1 GBP5 GBP7 GBP3 GBP2	disruption of cell in another organism
GO:0141060	7.38836409566e-08	0.833333333333	GBP1 GBP5 GBP7 GBP3 GBP2	disruption of anatomical structure in another organism
REAC:R-HSA-913531	2.53969571779e-07	0.833333333333	GBP1 GBP5 GBP7 GBP3 GBP2	Interferon Signaling
GO:0071346	3.78486635327e-07	0.833333333333	GBP1 GBP5 GBP7 GBP3 GBP2	cellular response to type II interferon
GO:0034341	1.2932381028e-06	0.833333333333	GBP1 GBP5 GBP7 GBP3 GBP2	response to type II interferon
GO:0001906	1.258414027e-05	0.833333333333	GBP1 GBP5 GBP7 GBP3 GBP2	cell killing
GO:0005525	6.90797235238e-05	0.833333333333	GBP1 GBP5 GBP7 GBP3 GBP2	GTP binding
GO:0032561	0.000122353943136	0.833333333333	GBP1 GBP5 GBP7 GBP3 GBP2	guanyl ribonucleotide binding
GO:0019001	0.000125533004234	0.833333333333	GBP1 GBP5 GBP7 GBP3 GBP2	guanyl nucleotide binding
REAC:R-HSA-1280215	0.000131694364092	0.833333333333	GBP1 GBP5 GBP7 GBP3 GBP2	Cytokine Signaling in Immune system
GO:0045087	0.000139852436632	1.0	GBP7 GBP1 GBP5 GBP3 CASP6 GBP2	innate immune response
GO:0001562	0.000161332517231	0.5	GBP2 GBP1 GBP7	response to protozoan
GO:0042832	0.000161332517231	0.5	GBP2 GBP1 GBP7	defense response to protozoan
GO:0003924	0.000353616039768	0.833333333333	GBP1 GBP5 GBP7 GBP3 GBP2	GTPase activity
GO:0140546	0.000407427378201	1.0	GBP7 GBP1 GBP5 GBP3 CASP6 GBP2	defense response to symbiont
GO:0098542	0.000644130628702	1.0	GBP7 GBP1 GBP5 GBP3 CASP6 GBP2	defense response to other organism
GO:0043068	0.00155387477464	0.833333333333	GBP1 GBP5 CASP6 GBP3 GBP2	positive regulation of programmed cell death
GO:0051707	0.00181068875531	1.0	GBP7 GBP1 GBP5 GBP3 CASP6 GBP2	response to other organism
GO:0043207	0.00181068875531	1.0	GBP7 GBP1 GBP5 GBP3 CASP6 GBP2	response to external biotic stimulus
GO:0009607	0.00220412781845	1.0	GBP7 GBP1 GBP5 GBP3 CASP6 GBP2	response to biotic stimulus
GO:0017111	0.00277926787058	0.833333333333	GBP1 GBP5 GBP7 GBP3 GBP2	ribonucleoside triphosphate phosphatase activity
GO:0044419	0.00398264360229	1.0	GBP7 GBP1 GBP5 GBP3 CASP6 GBP2	biological process involved in interspecies interaction between organisms
GO:0016462	0.00497235296634	0.833333333333	GBP1 GBP5 GBP7 GBP3 GBP2	pyrophosphatase activity
GO:0016817	0.00497235296634	0.833333333333	GBP1 GBP5 GBP7 GBP3 GBP2	hydrolase activity, acting on acid anhydrides
GO:0016818	0.00497235296634	0.833333333333	GBP1 GBP5 GBP7 GBP3 GBP2	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0035639	0.00541158540574	0.833333333333	GBP1 GBP5 GBP7 GBP3 GBP2	purine ribonucleoside triphosphate binding
GO:0006952	0.00556623702463	1.0	GBP7 GBP1 GBP5 GBP3 CASP6 GBP2	defense response
GO:0006955	0.00607918081447	1.0	GBP7 GBP1 GBP5 GBP3 CASP6 GBP2	immune response
GO:0071345	0.00645723353736	0.833333333333	GBP1 GBP5 GBP7 GBP3 GBP2	cellular response to cytokine stimulus
GO:0140973	0.00702301080125	0.333333333333	GBP5 GBP2	positive regulation of AIM2 inflammasome complex assembly
GO:0071310	0.00868484611575	1.0	GBP7 GBP1 GBP5 GBP3 CASP6 GBP2	cellular response to organic substance
GO:0032555	0.0102647533522	0.833333333333	GBP1 GBP5 GBP7 GBP3 GBP2	purine ribonucleotide binding
GO:0032553	0.0111594134233	0.833333333333	GBP1 GBP5 GBP7 GBP3 GBP2	ribonucleotide binding
GO:0042742	0.0112661365493	0.666666666667	GBP7 GBP2 GBP3 GBP1	defense response to bacterium
GO:0034097	0.0116294794164	0.833333333333	GBP1 GBP5 GBP7 GBP3 GBP2	response to cytokine
GO:0017076	0.018956843244	0.833333333333	GBP1 GBP5 GBP7 GBP3 GBP2	purine nucleotide binding
REAC:R-HSA-168256	0.0203260039291	0.833333333333	GBP1 GBP5 GBP7 GBP3 GBP2	Immune System
GO:0140971	0.0210651876021	0.333333333333	GBP5 GBP2	regulation of AIM2 inflammasome complex assembly
GO:0010033	0.0366453483103	1.0	GBP7 GBP1 GBP5 GBP3 CASP6 GBP2	response to organic substance
GO:0000166	0.0379188364707	0.833333333333	GBP1 GBP5 GBP7 GBP3 GBP2	nucleotide binding
GO:1901265	0.0382263716445	0.833333333333	GBP1 GBP5 GBP7 GBP3 GBP2	nucleoside phosphate binding
GO:0140970	0.042122686785	0.333333333333	GBP5 GBP2	AIM2 inflammasome complex assembly

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
GBP3	GBP2	0.999		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
GBP3	GBP1	0.998		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
GBP7	GBP2	0.993		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
GBP1	GBP2	0.988	0.284	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
GBP5	GBP1	0.987	0.21	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
GBP3	CASP6	0.895		bioplex3_WMM bioplex3_HCT116 WMM_only
GBP5	GBP3	0.868		bioplex_WMM bioplex3_WMM WMM_only
GBP5	GBP2	0.769	0.15	bioplex_WMM bioplex3_WMM WMM_only
CASP6	GBP2	0.671	0.048	bioplex3_WMM WMM_only
GBP7	GBP3	0.502		bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
GBP5	huMAP3_00632.1 huMAP3_00791.1 huMAP3_03356.1 huMAP3_06028.1 huMAP3_08761.1 huMAP3_09442.1 huMAP3_12098.1 huMAP3_15086.1 huMAP3_15160.1
GBP2	huMAP3_06824.1 huMAP3_08372.1 huMAP3_09442.1 huMAP3_12098.1 huMAP3_13465.1
GBP3	huMAP3_00791.1 huMAP3_08372.1 huMAP3_09442.1 huMAP3_12098.1 huMAP3_15160.1
GBP1	huMAP3_00791.1 huMAP3_08761.1 huMAP3_09442.1 huMAP3_12098.1 huMAP3_15160.1
CASP6	huMAP3_01020.1 huMAP3_12098.1 huMAP3_12125.1 huMAP3_13180.1 huMAP3_15160.1
GBP7	huMAP3_00494.1 huMAP3_12098.1 huMAP3_13465.1 huMAP3_14364.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_12098.1