hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12105.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ARHGEF11 | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | 5 | UniProt NCBI |
| PAK5 | Serine/threonine-protein kinase PAK 5 (EC 2.7.11.1) (p21-activated kinase 5) (PAK-5) (p21-activated kinase 7) (PAK-7) | 5 | UniProt NCBI |
| FAM124B | Protein FAM124B | 5 | UniProt NCBI |
| PAK4 | Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9013148 | 0.000453862022785 | 0.75 | PAK5 ARHGEF11 PAK4 | CDC42 GTPase cycle |
| REAC:R-HSA-428540 | 0.000798898068561 | 0.5 | PAK5 PAK4 | Activation of RAC1 |
| REAC:R-HSA-9013149 | 0.000897810107574 | 0.75 | PAK5 ARHGEF11 PAK4 | RAC1 GTPase cycle |
| WP:WP4564 | 0.00142851438729 | 0.5 | PAK5 PAK4 | Neural crest cell migration during development |
| WP:WP4565 | 0.00160392090455 | 0.5 | PAK5 PAK4 | Neural crest cell migration in cancer |
| WP:WP4534 | 0.00198508114189 | 0.5 | PAK5 PAK4 | Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms |
| WP:WP4205 | 0.00405547408869 | 0.5 | PAK5 PAK4 | MET in type 1 papillary renal cell carcinoma |
| KEGG:05211 | 0.00518715200321 | 0.5 | PAK5 PAK4 | Renal cell carcinoma |
| REAC:R-HSA-9013407 | 0.00573491177379 | 0.5 | PAK5 PAK4 | RHOH GTPase cycle |
| KEGG:04012 | 0.00710024614077 | 0.5 | PAK5 PAK4 | ErbB signaling pathway |
| WP:WP4263 | 0.00821485966847 | 0.5 | PAK5 PAK4 | Pancreatic adenocarcinoma pathway |
| WP:WP673 | 0.00821485966847 | 0.5 | PAK5 PAK4 | ErbB signaling pathway |
| WP:WP4541 | 0.011545786253 | 0.5 | PAK5 PAK4 | Hippo Merlin signaling dysregulation |
| KEGG:04660 | 0.0130545606238 | 0.5 | PAK5 PAK4 | T cell receptor signaling pathway |
| REAC:R-HSA-9012999 | 0.0139104893494 | 0.75 | PAK5 ARHGEF11 PAK4 | RHO GTPase cycle |
| WP:WP51 | 0.0205195911139 | 0.5 | PAK5 PAK4 | Regulation of actin cytoskeleton |
| REAC:R-HSA-422475 | 0.0253860120448 | 0.75 | PAK5 ARHGEF11 PAK4 | Axon guidance |
| WP:WP4223 | 0.0270438297073 | 0.5 | PAK5 PAK4 | Ras signaling |
| REAC:R-HSA-9675108 | 0.0283171453534 | 0.75 | PAK5 ARHGEF11 PAK4 | Nervous system development |
| KEGG:04360 | 0.0291410886797 | 0.5 | PAK5 PAK4 | Axon guidance |
| KEGG:04510 | 0.03673756538 | 0.5 | PAK5 PAK4 | Focal adhesion |
| KEGG:04014 | 0.0415303647194 | 0.5 | PAK5 PAK4 | Ras signaling pathway |
| KEGG:05170 | 0.0456663239038 | 0.5 | PAK5 PAK4 | Human immunodeficiency virus 1 infection |
| KEGG:04810 | 0.0466115978004 | 0.5 | PAK5 PAK4 | Regulation of actin cytoskeleton |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PAK4 | PAK5 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ARHGEF11 | PAK5 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ARHGEF11 | FAM124B | 0.934 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ARHGEF11 | PAK4 | 0.848 | bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
Related Complexes