hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12113.1
Complex Portal: CPX-18717
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NDST3 | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 (Glucosaminyl N-deacetylase/N-sulfotransferase 3) (NDST-3) (hNDST-3) (N-heparan sulfate sulfotransferase 3) (N-HSST 3) [Includes: Heparan sulfate N-deacetylase NDST3 (EC 3.-.-.-); [heparan sulfate]-glucosamine N-sulfotransferase NDST3 (EC 2.8.2.8)] | 5 | UniProt NCBI |
| KCTD13 | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (hBACURD1) (BTB/POZ domain-containing protein KCTD13) (Polymerase delta-interacting protein 1) (TNFAIP1-like protein) | 5 | UniProt NCBI |
| NDST4 | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 (EC 2.8.2.8) (Glucosaminyl N-deacetylase/N-sulfotransferase 4) (NDST-4) (N-heparan sulfate sulfotransferase 4) (N-HSST 4) [Includes: Heparan sulfate N-deacetylase 4 (EC 3.-.-.-); Heparan sulfate N-sulfotransferase 4 (EC 2.8.2.-)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00534 | 0.0001601688991 | 0.666666666667 | NDST3 NDST4 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin |
| WP:WP5395 | 0.00079501095268 | 0.666666666667 | NDST3 NDST4 | Glycosaminoglycan synthesis in fibroblasts |
| REAC:R-HSA-2022928 | 0.00257431960226 | 0.666666666667 | NDST3 NDST4 | HS-GAG biosynthesis |
| REAC:R-HSA-1638091 | 0.00833431912959 | 0.666666666667 | NDST3 NDST4 | Heparan sulfate/heparin (HS-GAG) metabolism |
| GO:0015016 | 0.00842684400117 | 0.666666666667 | NDST3 NDST4 | [heparan sulfate]-glucosamine N-sulfotransferase activity |
| WP:WP702 | 0.0101834993772 | 0.666666666667 | NDST3 NDST4 | Metapathway biotransformation Phase I and II |
| GO:0015014 | 0.0393180950424 | 0.666666666667 | NDST3 NDST4 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process |
| REAC:R-HSA-1630316 | 0.0406752460979 | 0.666666666667 | NDST3 NDST4 | Glycosaminoglycan metabolism |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NDST3 | NDST4 | 0.985 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| NDST3 | KCTD13 | 0.972 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NDST4 | KCTD13 | 0.055 | bioplex3_WMM WMM_only |
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