hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12119.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PAXIP1 | PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein) | 5 | UniProt NCBI |
| PAGR1 | PAXIP1-associated glutamate-rich protein 1 (Glutamate-rich coactivator interacting with SRC1) (GAS) (PAXIP1-associated protein 1) (PTIP-associated protein 1) | 5 | UniProt NCBI |
| UTY | Histone demethylase UTY (EC 1.14.11.68) (Ubiquitously-transcribed TPR protein on the Y chromosome) (Ubiquitously-transcribed Y chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase UTY) | 5 | UniProt NCBI |
| KMT2D | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0044666 | 8.68316823302e-09 | 1.0 | KMT2D PAGR1 PAXIP1 UTY | MLL3/4 complex |
| CORUM:6467 | 5.8916765743e-08 | 0.75 | PAGR1 PAXIP1 KMT2D | MLL4 complex |
| REAC:R-HSA-9772755 | 1.38374083551e-05 | 0.75 | PAGR1 PAXIP1 KMT2D | Formation of WDR5-containing histone-modifying complexes |
| GO:0035097 | 1.67184142401e-05 | 1.0 | KMT2D PAGR1 PAXIP1 UTY | histone methyltransferase complex |
| WP:WP4949 | 1.99075136102e-05 | 0.75 | PAGR1 PAXIP1 KMT2D | 16p11 2 proximal deletion syndrome |
| CORUM:6340 | 5.12488211613e-05 | 0.5 | PAXIP1 KMT2D | PITX2-MLL4-ASH2L-RBBP5-PTIP complex |
| GO:0034708 | 7.03249795192e-05 | 1.0 | KMT2D PAGR1 PAXIP1 UTY | methyltransferase complex |
| CORUM:6461 | 0.000184428417548 | 0.5 | PAGR1 PAXIP1 | MLL3 complex |
| CORUM:5195 | 0.000230514481314 | 0.5 | PAGR1 PAXIP1 | PTIP-HMT complex |
| REAC:R-HSA-5619507 | 0.000269276548599 | 0.75 | PAGR1 PAXIP1 KMT2D | Activation of HOX genes during differentiation |
| REAC:R-HSA-5617472 | 0.000269276548599 | 0.75 | PAGR1 PAXIP1 KMT2D | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| CORUM:3075 | 0.000338026191524 | 0.5 | PAXIP1 KMT2D | UTX-MLL2/3 complex |
| WP:WP5351 | 0.00103429913449 | 0.5 | PAGR1 PAXIP1 | Kleefstra syndrome |
| REAC:R-HSA-212165 | 0.00113904971457 | 0.75 | PAGR1 PAXIP1 KMT2D | Epigenetic regulation of gene expression |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PAGR1 | PAXIP1 | 0.999 | 0.176 | bioplex3_HEK293 bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only |
| PAGR1 | KMT2D | 0.998 | 0.106 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| PAGR1 | UTY | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PAXIP1 | KMT2D | 0.975 | 0.172 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| UTY | PAXIP1 | 0.91 | bioplex3_WMM WMM_only | |
| UTY | KMT2D | 0.902 | bioplex3_WMM WMM_only |
Related Complexes