hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_12128.1
Complex Portal: CPX-10981
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KEAP1 | Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) (Kelch-like protein 19) | 5 | UniProt NCBI |
| GH2 | Growth hormone variant (GH-V) (Growth hormone 2) (Placenta-specific growth hormone) | 5 | UniProt NCBI |
| PGAM5 | Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC 3.1.3.16) (Bcl-XL-binding protein v68) (Phosphoglycerate mutase family member 5) | 5 | UniProt NCBI |
| METAP1 | Methionine aminopeptidase 1 (MAP 1) (MetAP 1) (EC 3.4.11.18) (Peptidase M 1) | 5 | UniProt NCBI |
| ZNG1B | Zinc-regulated GTPase metalloprotein activator 1B (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 2) (COBW domain-containing protein 2) | 3 | UniProt NCBI |
| TCERG1 | Transcription elongation regulator 1 (TATA box-binding protein-associated factor 2S) (Transcription factor CA150) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5805 | 5.12534978153e-05 | 0.333333333333 | KEAP1 PGAM5 | PGAM5-KEAP1-NRF2 complex |
| WP:WP4357 | 0.0023190863075 | 0.333333333333 | KEAP1 PGAM5 | NRF2 ARE regulation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| METAP1 | GH2 | 0.997 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TCERG1 | ZNG1B | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| KEAP1 | ZNG1B | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| METAP1 | TCERG1 | 0.981 | 0.14 | bioplex_WMM bioplex3_WMM WMM_only | |
| METAP1 | ZNG1B | 0.958 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PGAM5 | ZNG1B | 0.955 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| PGAM5 | KEAP1 | 0.947 | 0.341777777778 | hein_WMM bioplex_WMM bioplex3_WMM boldt gupta_WMM WMM_only boldt_WMM | |
| METAP1 | KEAP1 | 0.131 | 0.172 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| METAP1 | PGAM5 | 0.1 | 0.102 | bioplex_WMM bioplex3_WMM WMM_only | |
| GH2 | PGAM5 | 0.007 | bioplex3_HEK293 bioplex () | ||
| TCERG1 | KEAP1 | 0.003 | 0.268 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| TCERG1 | PGAM5 | 0.003 | 0.108 | bioplex_WMM bioplex3_WMM boldt gupta_WMM fraction boldt_WMM |
Related Complexes