hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_12144.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| BEST1 | Bestrophin-1 (TU15B) (Vitelliform macular dystrophy protein 2) | 5 | UniProt NCBI |
| ENO1 | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | 5 | UniProt NCBI |
| ENO3 | Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase) | 5 | UniProt NCBI |
| ENO2 | Gamma-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 2) (Neural enolase) (Neuron-specific enolase) (NSE) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP534 | 0.000973512535349 | 0.666666666667 | ENO1 ENO2 | Glycolysis and gluconeogenesis |
| KEGG:00010 | 0.00143958269844 | 0.666666666667 | ENO1 ENO2 | Glycolysis / Gluconeogenesis |
| KEGG:01230 | 0.00168280767129 | 0.666666666667 | ENO1 ENO2 | Biosynthesis of amino acids |
| KEGG:03018 | 0.0019996401701 | 0.666666666667 | ENO1 ENO2 | RNA degradation |
| REAC:R-HSA-70263 | 0.00239054881557 | 0.666666666667 | ENO1 ENO2 | Gluconeogenesis |
| WP:WP4018 | 0.0031328951477 | 0.666666666667 | ENO1 ENO2 | Clear cell renal cell carcinoma pathways |
| KEGG:04066 | 0.00368672413844 | 0.666666666667 | ENO1 ENO2 | HIF-1 signaling pathway |
| KEGG:01200 | 0.00406958776216 | 0.666666666667 | ENO1 ENO2 | Carbon metabolism |
| WP:WP5355 | 0.00412431213363 | 0.666666666667 | ENO1 ENO2 | Metabolic Epileptic Disorders |
| GO:0004634 | 0.00421361424067 | 0.666666666667 | ENO1 ENO2 | phosphopyruvate hydratase activity |
| GO:0000015 | 0.00421361424067 | 0.666666666667 | ENO1 ENO2 | phosphopyruvate hydratase complex |
| REAC:R-HSA-70171 | 0.0141416283812 | 0.666666666667 | ENO1 ENO2 | Glycolysis |
| REAC:R-HSA-70326 | 0.0209338694285 | 0.666666666667 | ENO1 ENO2 | Glucose metabolism |
| HPA:0411283 | 0.0424050554332 | 0.333333333333 | BEST1 | retina; pigment epithelial cells[High] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ENO3 | ENO2 | 1.0 | 0.59 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| ENO1 | ENO2 | 0.999 | 0.584 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM |
| ENO1 | ENO3 | 0.999 | 0.822 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM treiber_WMM |
| BEST1 | ENO3 | 0.898 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| BEST1 | ENO1 | 0.004 | bioplex3_HEK293 bioplex () |
Related Complexes
| Genename | Complexes |
|---|---|
| BEST1 | huMAP3_04973.1 huMAP3_10575.1 huMAP3_10742.1 huMAP3_12144.1 |
| ENO1 | huMAP3_05072.1 huMAP3_12144.1 |
| ENO3 | huMAP3_05072.1 huMAP3_12144.1 |
| ENO2 | huMAP3_05072.1 huMAP3_12144.1 |