hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12157.1
Complex Portal: CPX-20160
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| AP3B1 | AP-3 complex subunit beta-1 (Adaptor protein complex AP-3 subunit beta-1) (Adaptor-related protein complex 3 subunit beta-1) (Beta-3A-adaptin) (Clathrin assembly protein complex 3 beta-1 large chain) | 5 | UniProt NCBI |
| EPB41L3 | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | 5 | UniProt NCBI |
| AP3M2 | AP-3 complex subunit mu-2 (Adaptor-related protein complex 3 subunit mu-2) (Clathrin assembly protein assembly protein complex 3 mu-2 medium chain) (Clathrin coat assembly protein AP47 homolog 2) (Clathrin coat-associated protein AP47 homolog 2) (Golgi adaptor AP-1 47 kDa protein homolog 2) (HA1 47 kDa subunit homolog 2) (Mu3B-adaptin) (P47B) | 5 | UniProt NCBI |
| TMEM63A | CSC1-like protein 1 (Transmembrane protein 63A) | 5 | UniProt NCBI |
| RNF167 | E3 ubiquitin-protein ligase RNF167 (EC 2.3.2.27) (RING finger protein 167) | 5 | UniProt NCBI |
| AP3M1 | AP-3 complex subunit mu-1 (AP-3 adaptor complex mu3A subunit) (Adaptor-related protein complex 3 subunit mu-1) (Mu-adaptin 3A) (Mu3A-adaptin) | 5 | UniProt NCBI |
| AP3S1 | AP-3 complex subunit sigma-1 (AP-3 complex subunit sigma-3A) (Adaptor-related protein complex 3 subunit sigma-1) (Clathrin-associated/assembly/adaptor protein, small 3) (Sigma-3A-adaptin) (Sigma3A-adaptin) (Sigma-adaptin 3a) | 5 | UniProt NCBI |
| AP3D1 | AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin) | 5 | UniProt NCBI |
| AP3S2 | AP-3 complex subunit sigma-2 (AP-3 complex subunit sigma-3B) (Adaptor-related protein complex 3 subunit sigma-2) (Sigma-3B-adaptin) (Sigma3B-adaptin) (Sigma-adaptin 3b) | 5 | UniProt NCBI |
| AP3B2 | AP-3 complex subunit beta-2 (Adaptor protein complex AP-3 subunit beta-2) (Adaptor-related protein complex 3 subunit beta-2) (Beta-3B-adaptin) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:59 | 3.1040134829e-22 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | AP3 adaptor complex |
| GO:0035654 | 2.12624923579e-19 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | clathrin-coated vesicle cargo loading, AP-3-mediated |
| GO:0035652 | 2.12624923579e-19 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | clathrin-coated vesicle cargo loading |
| CORUM:652 | 1.99456245305e-18 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | AP3-BLOC1 complex |
| GO:0030123 | 7.65174645029e-18 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | AP-3 adaptor complex |
| GO:0099517 | 6.75320850932e-15 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | synaptic vesicle transport along microtubule |
| GO:0048490 | 6.75320850932e-15 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | anterograde synaptic vesicle transport |
| GO:0099514 | 6.75320850932e-15 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | synaptic vesicle cytoskeletal transport |
| GO:0035459 | 5.5670526639e-13 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | vesicle cargo loading |
| GO:0048489 | 7.124545142e-13 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | synaptic vesicle transport |
| GO:0030119 | 1.42261833832e-12 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | AP-type membrane coat adaptor complex |
| GO:0097479 | 2.17729372247e-12 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | synaptic vesicle localization |
| GO:0016183 | 2.2691065e-12 | 0.5 | AP3D1 AP3B2 AP3S2 AP3M2 AP3S1 | synaptic vesicle coating |
| GO:0047496 | 4.75107383352e-12 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | vesicle transport along microtubule |
| GO:0008089 | 5.70026207713e-12 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | anterograde axonal transport |
| KEGG:04142 | 1.48935037712e-11 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | Lysosome |
| GO:0098930 | 3.73388506956e-11 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | axonal transport |
| GO:0016185 | 4.76240601112e-11 | 0.5 | AP3D1 AP3B2 AP3S2 AP3M2 AP3S1 | synaptic vesicle budding from presynaptic endocytic zone membrane |
| GO:0070142 | 4.76240601112e-11 | 0.5 | AP3D1 AP3B2 AP3S2 AP3M2 AP3S1 | synaptic vesicle budding |
| GO:0008088 | 8.13376136245e-11 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | axo-dendritic transport |
| GO:0099518 | 1.16459291706e-10 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | vesicle cytoskeletal trafficking |
| GO:0072384 | 2.79528375219e-10 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | organelle transport along microtubule |
| GO:0048475 | 1.22466787143e-09 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | coated membrane |
| GO:0030117 | 1.22466787143e-09 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | membrane coat |
| GO:1903232 | 1.93697256824e-08 | 0.5 | AP3B1 AP3S2 AP3D1 AP3M1 AP3S1 | melanosome assembly |
| GO:0010970 | 3.0317653251e-08 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | transport along microtubule |
| GO:0060155 | 4.59637226279e-08 | 0.5 | AP3B1 AP3S2 AP3D1 AP3M1 AP3S1 | platelet dense granule organization |
| GO:0099111 | 7.01631355434e-08 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | microtubule-based transport |
| GO:0051650 | 1.36371462669e-07 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | establishment of vesicle localization |
| GO:0030705 | 1.67918026877e-07 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | cytoskeleton-dependent intracellular transport |
| GO:0051648 | 1.74924762549e-07 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | vesicle localization |
| WP:WP5408 | 3.87562426749e-07 | 0.4 | AP3D1 AP3B2 AP3M2 AP3S1 | 15q25 copy number variation |
| GO:0006901 | 7.30343591783e-07 | 0.5 | AP3D1 AP3B2 AP3S2 AP3M2 AP3S1 | vesicle coating |
| GO:0032438 | 8.47898694602e-07 | 0.5 | AP3B1 AP3S2 AP3D1 AP3M1 AP3S1 | melanosome organization |
| GO:0048753 | 8.47898694602e-07 | 0.5 | AP3B1 AP3S2 AP3D1 AP3M1 AP3S1 | pigment granule organization |
| GO:0033363 | 1.12828086728e-06 | 0.5 | AP3B1 AP3S2 AP3D1 AP3M1 AP3S1 | secretory granule organization |
| GO:0051640 | 2.25542291982e-06 | 0.8 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 RNF167 | organelle localization |
| GO:0140238 | 2.74082007825e-06 | 0.5 | AP3D1 AP3B2 AP3S2 AP3M2 AP3S1 | presynaptic endocytosis |
| GO:0048488 | 2.74082007825e-06 | 0.5 | AP3D1 AP3B2 AP3S2 AP3M2 AP3S1 | synaptic vesicle endocytosis |
| GO:0005769 | 3.89038908753e-06 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | early endosome |
| GO:0007018 | 3.99281461086e-06 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | microtubule-based movement |
| GO:0016050 | 5.15065333723e-06 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | vesicle organization |
| GO:0036465 | 7.07635361346e-06 | 0.5 | AP3D1 AP3B2 AP3S2 AP3M2 AP3S1 | synaptic vesicle recycling |
| GO:0033059 | 7.78176353146e-06 | 0.5 | AP3B1 AP3S2 AP3D1 AP3M1 AP3S1 | cellular pigmentation |
| CORUM:2308 | 3.07577115383e-05 | 0.2 | AP3D1 AP3S1 | AP3D1-AP3S1 complex |
| CORUM:2307 | 3.07577115383e-05 | 0.2 | AP3D1 AP3S2 | AP3D1-AP3S2 complex |
| GO:0006900 | 3.11463395308e-05 | 0.5 | AP3D1 AP3B2 AP3S2 AP3M2 AP3S1 | vesicle budding from membrane |
| GO:0043473 | 3.34269433414e-05 | 0.5 | AP3B1 AP3S2 AP3D1 AP3M1 AP3S1 | pigmentation |
| GO:0051656 | 3.34544308976e-05 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | establishment of organelle localization |
| GO:0005768 | 6.09151651628e-05 | 0.8 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 RNF167 | endosome |
| GO:0099504 | 0.000212929800814 | 0.5 | AP3D1 AP3B2 AP3S2 AP3M2 AP3S1 | synaptic vesicle cycle |
| GO:0099003 | 0.000245593883206 | 0.5 | AP3D1 AP3B2 AP3S2 AP3M2 AP3S1 | vesicle-mediated transport in synapse |
| GO:0031410 | 0.00137129474097 | 0.9 | AP3D1 AP3S1 TMEM63A AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 RNF167 | cytoplasmic vesicle |
| GO:0097708 | 0.00139355619292 | 0.9 | AP3D1 AP3S1 TMEM63A AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 RNF167 | intracellular vesicle |
| GO:0007017 | 0.00279771527789 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | microtubule-based process |
| HP:0011125 | 0.00412666115323 | 0.2 | AP3B1 AP3D1 | Abnormality of dermal melanosomes |
| GO:0010256 | 0.00655087143675 | 0.6 | EPB41L3 AP3D1 AP3S1 AP3M1 AP3S2 AP3B1 | endomembrane system organization |
| GO:0006897 | 0.00843026202571 | 0.6 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3M2 | endocytosis |
| GO:0098796 | 0.0198717043793 | 0.7 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3B1 AP3M2 | membrane protein complex |
| GO:0061024 | 0.0299014247578 | 0.6 | EPB41L3 AP3D1 AP3S1 AP3B2 AP3S2 AP3M2 | membrane organization |
| GO:0098657 | 0.0413524311538 | 0.6 | AP3D1 AP3S1 AP3B2 AP3M1 AP3S2 AP3M2 | import into cell |
| HP:0001022 | 0.0493214801054 | 0.2 | AP3B1 AP3D1 | Albinism |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| AP3M1 | AP3S1 | 1.0 | 0.522 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction | |
| AP3S1 | AP3B2 | 1.0 | 0.054 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| AP3M1 | AP3B2 | 1.0 | 0.044 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| AP3B1 | AP3S1 | 1.0 | 0.262 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction | |
| AP3B1 | AP3M1 | 1.0 | 0.782 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| AP3M1 | AP3D1 | 1.0 | 0.794 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| AP3M2 | AP3S1 | 1.0 | 0.166 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction | |
| AP3S1 | AP3D1 | 0.999 | 0.482 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| AP3S1 | RNF167 | 0.999 | 0.044 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| AP3B1 | AP3M2 | 0.999 | 0.28 |
mutually_exclusive (Q9Y2T2)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction |
| EPB41L3 | AP3M2 | 0.998 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | ||
| AP3M2 | AP3M1 | 0.998 | 0.636 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| EPB41L3 | AP3B1 | 0.996 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | ||
| EPB41L3 | AP3M1 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | ||
| AP3M2 | AP3D1 | 0.995 | 0.604 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction | |
| AP3B1 | AP3D1 | 0.993 | 0.806 |
mutually_exclusive (Q9Y2T2)
structurally_consistent (dimer) |
bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| AP3D1 | TMEM63A | 0.992 | 0.256 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| AP3M1 | AP3S2 | 0.991 | 0.068 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| AP3B1 | AP3B2 | 0.991 | 0.04 |
mutually_exclusive (Q9Y2T2)
|
bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| AP3S2 | TMEM63A | 0.99 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| AP3M2 | AP3B2 | 0.98 | 0.036 |
mutually_exclusive (Q9Y2T2)
|
bioplex_WMM bioplex3_WMM WMM_only |
| AP3M2 | AP3S2 | 0.978 | 0.074 |
mutually_exclusive (Q9Y2T2)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| AP3S1 | TMEM63A | 0.973 | 0.102 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| EPB41L3 | AP3D1 | 0.971 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | ||
| AP3S1 | AP3S2 | 0.94 | 0.064 |
mutually_exclusive (O14617)
|
bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| AP3D1 | AP3S2 | 0.938 | 0.136 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| AP3D1 | AP3B2 | 0.921 | 0.038 |
mutually_exclusive (Q9Y2T2)
|
bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| EPB41L3 | AP3B2 | 0.913 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| EPB41L3 | AP3S1 | 0.859 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | ||
| AP3B1 | RNF167 | 0.849 | 0.106 | bioplex_WMM bioplex3_WMM WMM_only | |
| AP3B1 | AP3S2 | 0.834 | 0.066 |
structurally_consistent (O14617)
|
bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| AP3B2 | RNF167 | 0.749 | 0.022 | bioplex_WMM bioplex3_WMM WMM_only | |
| AP3M2 | RNF167 | 0.747 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only | |
| AP3S2 | AP3B2 | 0.747 | 0.06 | bioplex_WMM bioplex3_WMM WMM_only | |
| EPB41L3 | AP3S2 | 0.741 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| AP3D1 | RNF167 | 0.667 | 0.102 | bioplex_WMM bioplex3_WMM WMM_only | |
| AP3M1 | RNF167 | 0.622 | 0.094 | bioplex_WMM bioplex3_WMM WMM_only | |
| AP3S2 | RNF167 | 0.121 | 0.066 | bioplex_WMM bioplex3_WMM WMM_only | |
| AP3B1 | TMEM63A | 0.096 | 0.116 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RNF167 | TMEM63A | 0.057 | 0.084 | bioplex_WMM bioplex3_WMM WMM_only | |
| AP3M1 | TMEM63A | 0.039 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| EPB41L3 | RNF167 | 0.008 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes