hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_12169.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EYA4 | Eyes absent homolog 4 (EC 3.1.3.48) | 5 | UniProt NCBI |
| SIX5 | Homeobox protein SIX5 (DM locus-associated homeodomain protein) (Sine oculis homeobox homolog 5) | 5 | UniProt NCBI |
| EYA1 | Eyes absent homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) | 5 | UniProt NCBI |
| SIX1 | Homeobox protein SIX1 (Sine oculis homeobox homolog 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0011388 | 1.83076395158e-08 | 0.75 | SIX5 EYA1 SIX1 | Enlarged cochlear aqueduct |
| HP:0009796 | 9.1528800211e-08 | 0.75 | SIX5 EYA1 SIX1 | Branchial cyst |
| HP:0008586 | 1.60167177672e-07 | 0.75 | SIX5 EYA1 SIX1 | Hypoplasia of the cochlea |
| HP:0011395 | 2.5625432796e-07 | 0.75 | SIX5 EYA1 SIX1 | Aplasia/Hypoplasia of the cochlea |
| HP:0008774 | 3.84361757466e-07 | 0.75 | SIX5 EYA1 SIX1 | Aplasia/Hypoplasia of the inner ear |
| HP:0009794 | 3.73207457287e-06 | 0.75 | SIX5 EYA1 SIX1 | Branchial anomaly |
| HP:0004452 | 3.73207457287e-06 | 0.75 | SIX5 EYA1 SIX1 | Abnormality of the middle ear ossicles |
| HP:0000074 | 4.43161090403e-06 | 0.75 | SIX5 EYA1 SIX1 | Ureteropelvic junction obstruction |
| CORUM:7363 | 5.12628525639e-06 | 0.5 | EYA1 SIX1 | EYA1-SIX1 complex |
| HP:0008609 | 1.18865274487e-05 | 0.75 | SIX5 EYA1 SIX1 | Abnormal middle ear morphology |
| HP:0000375 | 1.33716561973e-05 | 0.75 | SIX5 EYA1 SIX1 | Abnormal cochlea morphology |
| HP:0000071 | 1.33716561973e-05 | 0.75 | SIX5 EYA1 SIX1 | Ureteral stenosis |
| HP:0000402 | 1.85574544538e-05 | 0.75 | SIX5 EYA1 SIX1 | Stenosis of the external auditory canal |
| HP:0006000 | 2.49344480699e-05 | 0.75 | SIX5 EYA1 SIX1 | Ureteral obstruction |
| HP:0011481 | 4.86971965604e-05 | 0.75 | SIX5 EYA1 SIX1 | Abnormal lacrimal duct morphology |
| HP:0000413 | 8.9495616948e-05 | 0.75 | SIX5 EYA1 SIX1 | Atresia of the external auditory canal |
| HP:0000614 | 0.000190105075273 | 0.75 | SIX5 EYA1 SIX1 | Abnormal nasolacrimal system morphology |
| HP:0011390 | 0.000199293446021 | 0.75 | SIX5 EYA1 SIX1 | Abnormal inner ear morphology |
| HP:0000110 | 0.000199293446021 | 0.75 | SIX5 EYA1 SIX1 | Renal dysplasia |
| HP:0004458 | 0.000200620835246 | 0.5 | EYA1 SIX1 | Dilatated internal auditory canal |
| HP:0009798 | 0.000200620835246 | 0.5 | EYA1 SIX1 | Euthyroid goiter |
| HP:0000384 | 0.000218547832795 | 0.75 | SIX5 EYA1 SIX1 | Preauricular skin tag |
| HP:0000359 | 0.000295627549748 | 0.75 | SIX5 EYA1 SIX1 | Abnormality of the inner ear |
| HP:0008572 | 0.000307929500389 | 0.75 | SIX5 EYA1 SIX1 | External ear malformation |
| HP:0000372 | 0.000333546420735 | 0.75 | SIX5 EYA1 SIX1 | Abnormality of the auditory canal |
| HP:0100274 | 0.000334337547576 | 0.5 | EYA1 SIX1 | Gustatory lacrimation |
| HP:0010609 | 0.000360544079166 | 0.75 | SIX5 EYA1 SIX1 | Skin tags |
| HP:0000003 | 0.0004188257634 | 0.75 | SIX5 EYA1 SIX1 | Multicystic kidney dysplasia |
| HP:0000383 | 0.000630553804854 | 0.75 | SIX5 EYA1 SIX1 | Abnormal periauricular region morphology |
| HP:0011387 | 0.000701980712879 | 0.5 | EYA1 SIX1 | Enlarged vestibular aqueduct |
| HP:0000376 | 0.000701980712879 | 0.5 | EYA1 SIX1 | Incomplete partition of the cochlea type II |
| HP:0011373 | 0.000935888865729 | 0.5 | EYA1 SIX1 | Incomplete partition of the cochlea |
| HP:0009797 | 0.000935888865729 | 0.5 | EYA1 SIX1 | Cholesteatoma |
| HP:0004712 | 0.000935888865729 | 0.5 | EYA1 SIX1 | Renal malrotation |
| HP:0100799 | 0.000935888865729 | 0.5 | EYA1 SIX1 | Neoplasm of the middle ear |
| HP:0000370 | 0.000936075998968 | 1.0 | EYA4 SIX1 EYA1 SIX5 | Abnormality of the middle ear |
| HP:0008554 | 0.00120317586686 | 0.5 | EYA1 SIX1 | Cochlear malformation |
| HP:0000324 | 0.0013766086176 | 0.75 | SIX5 EYA1 SIX1 | Facial asymmetry |
| WP:WP4823 | 0.00142851438729 | 0.5 | EYA1 SIX1 | Genes controlling nephrogenesis |
| HP:0007925 | 0.00150383256857 | 0.5 | EYA1 SIX1 | Lacrimal duct aplasia |
| HP:0000799 | 0.00150383256857 | 0.5 | EYA1 SIX1 | Renal steatosis |
| HP:0011094 | 0.00150383256857 | 0.5 | EYA1 SIX1 | Increased overbite |
| HP:0009795 | 0.00150383256857 | 0.5 | EYA1 SIX1 | Branchial fistula |
| HP:0100267 | 0.00183784982408 | 0.5 | EYA1 SIX1 | Lip pit |
| WP:WP5236 | 0.0027493593259 | 0.5 | EYA1 SIX1 | Markers of kidney cell lineage |
| WP:WP5053 | 0.0027493593259 | 0.5 | EYA1 SIX1 | Development of ureteric collection system |
| HP:0010628 | 0.00292857106518 | 0.75 | SIX5 EYA1 SIX1 | Facial palsy |
| HP:0010827 | 0.0029847353034 | 0.75 | SIX5 EYA1 SIX1 | Abnormal seventh cranial physiology |
| HP:0007678 | 0.00303997345979 | 0.5 | EYA1 SIX1 | Lacrimal duct stenosis |
| HP:0008771 | 0.00486237653059 | 0.75 | SIX5 EYA1 SIX1 | Aplasia/Hypoplasia of the ear |
| HP:0012780 | 0.0057098705025 | 0.5 | EYA1 SIX1 | Neoplasm of the ear |
| HP:0011384 | 0.0057098705025 | 0.5 | EYA1 SIX1 | Abnormality of the internal auditory canal |
| HP:0030319 | 0.0058618765749 | 0.75 | SIX5 EYA1 SIX1 | Weakness of facial musculature |
| HP:0000076 | 0.0058618765749 | 0.75 | SIX5 EYA1 SIX1 | Vesicoureteral reflux |
| HP:0025634 | 0.00803184965878 | 0.75 | SIX5 EYA1 SIX1 | Abnormal ureter physiology |
| HP:0004426 | 0.00836362825601 | 0.75 | SIX5 EYA1 SIX1 | Abnormal cheek morphology |
| HP:0000126 | 0.00893659963699 | 0.75 | SIX5 EYA1 SIX1 | Hydronephrosis |
| HP:0006824 | 0.00978169098064 | 0.75 | SIX5 EYA1 SIX1 | Cranial nerve paralysis |
| HP:0031910 | 0.0100325283905 | 0.75 | SIX5 EYA1 SIX1 | Abnormal cranial nerve physiology |
| HP:0011376 | 0.0108451581837 | 0.5 | EYA1 SIX1 | Abnormal morphology of the vestibule of the inner ear |
| HP:0000107 | 0.0109440306967 | 0.75 | SIX5 EYA1 SIX1 | Renal cyst |
| HP:0010946 | 0.0110785663677 | 0.75 | SIX5 EYA1 SIX1 | Dilatation of the renal pelvis |
| HP:0010944 | 0.0123391078674 | 0.75 | SIX5 EYA1 SIX1 | Abnormal renal pelvis morphology |
| HP:0004742 | 0.0135443934278 | 0.5 | EYA1 SIX1 | Abnormal renal collecting system morphology |
| HP:0000579 | 0.0135443934278 | 0.5 | EYA1 SIX1 | Nasolacrimal duct obstruction |
| HP:0000301 | 0.0161575597254 | 0.75 | SIX5 EYA1 SIX1 | Abnormality of facial musculature |
| HP:0000410 | 0.0176079483787 | 0.5 | EYA1 SIX1 | Mixed hearing impairment |
| HP:0000278 | 0.023683386712 | 0.75 | SIX5 EYA1 SIX1 | Retrognathia |
| HP:0008678 | 0.0239076954829 | 0.75 | SIX5 EYA1 SIX1 | Renal hypoplasia/aplasia |
| REAC:R-HSA-5693565 | 0.0253175164514 | 0.5 | EYA4 EYA1 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
| REAC:R-HSA-5693606 | 0.0260384914588 | 0.5 | EYA4 EYA1 | DNA Double Strand Break Response |
| HP:0000069 | 0.0274431881859 | 0.75 | SIX5 EYA1 SIX1 | Abnormality of the ureter |
| KEGG:05202 | 0.0295193078423 | 0.5 | EYA1 SIX1 | Transcriptional misregulation in cancer |
| HP:0004467 | 0.0315158796726 | 0.5 | EYA1 SIX1 | Preauricular pit |
| HP:0000083 | 0.0321230291111 | 0.75 | SIX5 EYA1 SIX1 | Renal insufficiency |
| HP:0000853 | 0.0329787201379 | 0.5 | EYA1 SIX1 | Goiter |
| HP:0100277 | 0.036003514982 | 0.5 | EYA1 SIX1 | Periauricular skin pits |
| HP:0000365 | 0.0366506194199 | 1.0 | EYA4 SIX1 EYA1 SIX5 | Hearing impairment |
| HP:0000113 | 0.0391604009626 | 0.5 | EYA1 SIX1 | Polycystic kidney dysplasia |
| HP:0000364 | 0.0392063646668 | 1.0 | EYA4 SIX1 EYA1 SIX5 | Hearing abnormality |
| HP:0031704 | 0.0464502255589 | 1.0 | EYA4 SIX1 EYA1 SIX5 | Abnormal ear physiology |
| HP:0031703 | 0.0490742875352 | 1.0 | EYA4 SIX1 EYA1 SIX5 | Abnormal ear morphology |
| CORUM:7364 | 0.049938562206 | 0.25 | EYA1 | EYA1-SIX2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| EYA1 | SIX1 | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| EYA4 | SIX1 | 0.976 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| EYA4 | SIX5 | 0.975 | 0.154 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| EYA1 | SIX5 | 0.897 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| EYA1 | EYA4 | 0.528 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes