hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12173.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CD300LB | CMRF35-like molecule 7 (CLM-7) (CD300 antigen-like family member B) (CMRF35-A2) (Immune receptor expressed on myeloid cells 3) (IREM-3) (Leukocyte mono-Ig-like receptor 5) (Triggering receptor expressed on myeloid cells 5) (TREM-5) (CD antigen CD300b) | 5 | UniProt NCBI |
| RAD51D | DNA repair protein RAD51 homolog 4 (R51H3) (RAD51 homolog D) (RAD51-like protein 3) (TRAD) | 5 | UniProt NCBI |
| RAD51B | DNA repair protein RAD51 homolog 2 (R51H2) (RAD51 homolog B) (Rad51B) (RAD51-like protein 1) | 5 | UniProt NCBI |
| XRCC2 | DNA repair protein XRCC2 (X-ray repair cross-complementing protein 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:251 | 2.80628050973e-09 | 0.75 | XRCC2 RAD51D RAD51B | BCDX2 complex |
| CORUM:68 | 2.80628050973e-09 | 0.75 | XRCC2 RAD51D RAD51B | BCDX2 complex |
| CORUM:258 | 2.80628050973e-09 | 0.75 | XRCC2 RAD51D RAD51B | BCDX2 complex |
| CORUM:261 | 7.01534115619e-09 | 0.75 | XRCC2 RAD51D RAD51B | RAD51B-RAD51C-RAD51D-XRCC2-XRCC3 complex |
| GO:0033063 | 1.53784171933e-06 | 0.75 | XRCC2 RAD51D RAD51B | Rad51B-Rad51C-Rad51D-XRCC2 complex |
| REAC:R-HSA-9709603 | 2.8370403595e-06 | 0.75 | XRCC2 RAD51D RAD51B | Impaired BRCA2 binding to PALB2 |
| REAC:R-HSA-9701192 | 3.2237438451e-06 | 0.75 | XRCC2 RAD51D RAD51B | Defective homologous recombination repair (HRR) due to BRCA1 loss of function |
| REAC:R-HSA-9704646 | 3.2237438451e-06 | 0.75 | XRCC2 RAD51D RAD51B | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function |
| REAC:R-HSA-9704331 | 3.2237438451e-06 | 0.75 | XRCC2 RAD51D RAD51B | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function |
| REAC:R-HSA-9701193 | 3.2237438451e-06 | 0.75 | XRCC2 RAD51D RAD51B | Defective homologous recombination repair (HRR) due to PALB2 loss of function |
| KEGG:03440 | 3.38522311544e-06 | 0.75 | XRCC2 RAD51D RAD51B | Homologous recombination |
| REAC:R-HSA-5693554 | 4.0993398561e-06 | 0.75 | XRCC2 RAD51D RAD51B | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
| CORUM:262 | 5.12628525639e-06 | 0.5 | XRCC2 RAD51D | RAD51L3-XRCC2 complex |
| REAC:R-HSA-5693568 | 7.64413736449e-06 | 0.75 | XRCC2 RAD51D RAD51B | Resolution of D-loop Structures through Holliday Junction Intermediates |
| GO:0033061 | 7.68841921772e-06 | 0.75 | XRCC2 RAD51D RAD51B | DNA recombinase mediator complex |
| REAC:R-HSA-5693537 | 8.38346160394e-06 | 0.75 | XRCC2 RAD51D RAD51B | Resolution of D-Loop Structures |
| REAC:R-HSA-5693616 | 1.28002609524e-05 | 0.75 | XRCC2 RAD51D RAD51B | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-9701190 | 1.38374083551e-05 | 0.75 | XRCC2 RAD51D RAD51B | Defective homologous recombination repair (HRR) due to BRCA2 loss of function |
| REAC:R-HSA-9675136 | 1.38374083551e-05 | 0.75 | XRCC2 RAD51D RAD51B | Diseases of DNA Double-Strand Break Repair |
| CORUM:2228 | 1.53774525569e-05 | 0.5 | XRCC2 RAD51D | BLM-RAD51L3-XRCC2 complex |
| REAC:R-HSA-5693579 | 1.60766305396e-05 | 0.75 | XRCC2 RAD51D RAD51B | Homologous DNA Pairing and Strand Exchange |
| REAC:R-HSA-9675135 | 2.57917427086e-05 | 0.75 | XRCC2 RAD51D RAD51B | Diseases of DNA repair |
| REAC:R-HSA-5685942 | 6.40033583955e-05 | 0.75 | XRCC2 RAD51D RAD51B | HDR through Homologous Recombination (HRR) |
| GO:0000400 | 0.000261258639543 | 0.75 | XRCC2 RAD51D RAD51B | four-way junction DNA binding |
| REAC:R-HSA-5693567 | 0.000422025999557 | 0.75 | XRCC2 RAD51D RAD51B | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 0.000487256563506 | 0.75 | XRCC2 RAD51D RAD51B | Homology Directed Repair |
| REAC:R-HSA-5693532 | 0.000897810107574 | 0.75 | XRCC2 RAD51D RAD51B | DNA Double-Strand Break Repair |
| GO:0000217 | 0.00209449363787 | 0.75 | XRCC2 RAD51D RAD51B | DNA secondary structure binding |
| REAC:R-HSA-73894 | 0.00653220236003 | 0.75 | XRCC2 RAD51D RAD51B | DNA Repair |
| GO:0005657 | 0.0167406494658 | 0.75 | XRCC2 RAD51D RAD51B | replication fork |
| GO:0042148 | 0.042122686785 | 0.5 | XRCC2 RAD51D | DNA strand invasion |
| CORUM:260 | 0.049938562206 | 0.25 | RAD51B | RAD51B-RAD51C complex |
| CORUM:256 | 0.049938562206 | 0.25 | RAD51B | RAD51B-RAD51C complex |
| CORUM:5683 | 0.049938562206 | 0.25 | XRCC2 | hRAD51C-hXRCC3 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RAD51D | XRCC2 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RAD51B | XRCC2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RAD51D | RAD51B | 0.997 | 0.186 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RAD51B | CD300LB | 0.927 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| CD300LB | huMAP3_12173.1 huMAP3_12847.1 |
| RAD51D | huMAP3_03417.1 huMAP3_07905.1 huMAP3_12173.1 huMAP3_12847.1 |
| RAD51B | huMAP3_03417.1 huMAP3_07905.1 huMAP3_12173.1 huMAP3_12847.1 |
| XRCC2 | huMAP3_03417.1 huMAP3_07905.1 huMAP3_12173.1 huMAP3_12847.1 huMAP3_14586.1 |