hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_12180.1

Complex Portal: CPX-21202

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
UBR7	Putative E3 ubiquitin-protein ligase UBR7 (EC 2.3.2.27) (N-recognin-7) (RING-type E3 ubiquitin transferase UBR7)	4	UniProt NCBI
TIMELESS	Protein timeless homolog (hTIM)	5	UniProt NCBI
MCM3	DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102)	5	UniProt NCBI
GINS1	DNA replication complex GINS protein PSF1 (GINS complex subunit 1)	5	UniProt NCBI
MCMBP	Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein)	5	UniProt NCBI
MCM2	DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)	5	UniProt NCBI
MCM5	DNA replication licensing factor MCM5 (EC 3.6.4.12) (CDC46 homolog) (P1-CDC46)	5	UniProt NCBI
SPIN2B	Spindlin-2B (Spindlin-like protein 2B) (SPIN-2) (SPIN-2B)	5	UniProt NCBI
MCM6	DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM)	5	UniProt NCBI
CLSPN	Claspin (hClaspin)	5	UniProt NCBI
SPIN4	Spindlin-4	3	UniProt NCBI
GINS4	DNA replication complex GINS protein SLD5 (GINS complex subunit 4) [Cleaved into: DNA replication complex GINS protein SLD5, N-terminally processed]	5	UniProt NCBI
MCM7	DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3)	5	UniProt NCBI
GINS3	DNA replication complex GINS protein PSF3 (GINS complex subunit 3)	5	UniProt NCBI
TIPIN	TIMELESS-interacting protein	5	UniProt NCBI
MCM4	DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21)	5	UniProt NCBI
GINS2	DNA replication complex GINS protein PSF2 (GINS complex subunit 2)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-176974	3.19611927251e-14	0.461538461538	GINS4 GINS1 GINS3 GINS2 MCM2 MCM6	Unwinding of DNA
GO:0071162	2.92565102444e-12	0.461538461538	GINS4 GINS1 GINS3 GINS2 MCM2 MCM6	CMG complex
GO:0031261	5.84889826869e-12	0.461538461538	GINS4 GINS1 GINS3 GINS2 MCM2 MCM6	DNA replication preinitiation complex
GO:0006261	1.93535411059e-11	0.692307692308	GINS4 GINS3 TIMELESS MCMBP GINS1 GINS2 MCM6 MCM2 TIPIN	DNA-templated DNA replication
CORUM:678	2.11387990692e-11	0.307692307692	GINS3 GINS1 GINS2 GINS4	GINS complex
REAC:R-HSA-69190	3.10885389095e-11	0.461538461538	GINS4 GINS1 GINS3 GINS2 MCM2 MCM6	DNA strand elongation
GO:0006268	3.4222161851e-10	0.461538461538	GINS4 GINS1 GINS3 GINS2 MCM2 MCM6	DNA unwinding involved in DNA replication
GO:0006260	9.27291899749e-10	0.692307692308	GINS4 GINS3 TIMELESS MCMBP GINS1 GINS2 MCM6 MCM2 TIPIN	DNA replication
GO:0000811	1.88135311715e-08	0.307692307692	GINS3 GINS1 GINS2 GINS4	GINS complex
GO:0000228	2.00502393521e-08	0.615384615385	GINS4 GINS1 TIMELESS GINS3 GINS2 MCM6 MCM2 TIPIN	nuclear chromosome
GO:0032508	5.08630500987e-08	0.461538461538	GINS4 GINS1 GINS3 GINS2 MCM2 MCM6	DNA duplex unwinding
REAC:R-HSA-69239	1.14854182805e-07	0.461538461538	GINS4 GINS1 GINS3 GINS2 MCM2 MCM6	Synthesis of DNA
GO:0032392	1.42890046098e-07	0.461538461538	GINS4 GINS1 GINS3 GINS2 MCM2 MCM6	DNA geometric change
GO:0071103	3.10706296152e-07	0.461538461538	GINS4 GINS1 GINS3 GINS2 MCM2 MCM6	DNA conformation change
REAC:R-HSA-69242	6.64075162689e-07	0.461538461538	GINS4 GINS1 GINS3 GINS2 MCM2 MCM6	S Phase
REAC:R-HSA-69306	1.14299338104e-06	0.461538461538	GINS4 GINS1 GINS3 GINS2 MCM2 MCM6	DNA Replication
GO:0033260	2.71545740586e-06	0.384615384615	GINS3 GINS1 TIPIN MCM6 MCM2	nuclear DNA replication
GO:0044786	4.97816536011e-06	0.384615384615	GINS3 GINS1 TIPIN MCM6 MCM2	cell cycle DNA replication
GO:0000727	6.18707875607e-06	0.307692307692	MCM2 GINS2 MCM6 GINS4	double-strand break repair via break-induced replication
GO:1902969	1.33921251982e-05	0.307692307692	GINS3 GINS1 MCM6 MCM2	mitotic DNA replication
CORUM:2792	4.10333215354e-05	0.153846153846	MCM2 MCM6	MCM2-MCM4-MCM6-MCM7 complex
CORUM:1452	4.10333215354e-05	0.153846153846	MCM2 MCM6	MCM2-MCM6-MCM7 complex
CORUM:387	4.10333215354e-05	0.153846153846	MCM2 MCM6	MCM complex
GO:0006259	8.23671929626e-05	0.692307692308	GINS4 GINS3 TIMELESS MCMBP GINS1 GINS2 MCM6 MCM2 TIPIN	DNA metabolic process
REAC:R-HSA-1640170	0.000119825041129	0.538461538462	GINS4 GINS1 GINS3 MCM6 MCM2 CLSPN GINS2	Cell Cycle
REAC:R-HSA-69278	0.0007982758581	0.461538461538	GINS4 GINS1 GINS3 GINS2 MCM2 MCM6	Cell Cycle, Mitotic
REAC:R-HSA-176187	0.00105454877198	0.230769230769	MCM2 MCM6 CLSPN	Activation of ATR in response to replication stress
GO:0090329	0.00152094886488	0.307692307692	TIPIN MCM2 TIMELESS MCM6	regulation of DNA-templated DNA replication
CORUM:5611	0.00224666054346	0.153846153846	MCM2 MCM6	Emerin complex 24
GO:0051276	0.0038802091366	0.538461538462	GINS4 GINS1 MCMBP GINS3 MCM6 MCM2 GINS2	chromosome organization
GO:0042555	0.00451731143698	0.230769230769	MCM2 MCMBP MCM6	MCM complex
GO:0000724	0.00831673252973	0.384615384615	MCM2 GINS4 GINS2 TIMELESS MCM6	double-strand break repair via homologous recombination
GO:0000725	0.00942183697941	0.384615384615	MCM2 GINS4 GINS2 TIMELESS MCM6	recombinational repair
REAC:R-HSA-5693607	0.0168763084157	0.230769230769	TIPIN TIMELESS CLSPN	Processing of DNA double-strand break ends
GO:0022402	0.0188869246022	0.615384615385	TIPIN GINS3 TIMELESS MCMBP GINS1 MCM6 MCM2 CLSPN	cell cycle process
GO:0000076	0.0222599970629	0.230769230769	TIPIN TIMELESS CLSPN	DNA replication checkpoint signaling
KEGG:03030	0.0258788657518	0.153846153846	MCM2 MCM6	DNA replication
GO:0005654	0.0261351282479	0.923076923077	GINS3 SPIN4 GINS4 CLSPN TIMELESS MCMBP GINS1 GINS2 MCM6 MCM2 SPIN2B TIPIN	nucleoplasm
GO:0032993	0.0279182511994	0.615384615385	GINS4 GINS1 TIMELESS GINS3 GINS2 MCM6 MCM2 TIPIN	protein-DNA complex
REAC:R-HSA-5693567	0.0427404690526	0.230769230769	TIPIN TIMELESS CLSPN	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
GO:0006974	0.0444050741876	0.538461538462	TIPIN GINS4 TIMELESS MCM6 MCM2 CLSPN GINS2	DNA damage response
GO:0140513	0.0478748528772	0.615384615385	GINS4 GINS1 TIMELESS GINS3 GINS2 MCM6 MCM2 TIPIN	nuclear protein-containing complex
REAC:R-HSA-5693538	0.0492097613872	0.230769230769	TIPIN TIMELESS CLSPN	Homology Directed Repair
CORUM:2791	0.0499717467432	0.0769230769231	MCM6	MCM4-MCM6-MCM7 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
GINS2	GINS4	1.0	0.93
MCMBP	MCM5	1.0	0.314	mixed_interface
GINS3	GINS1	1.0	0.93	structurally_consistent (dimer)
TIPIN	TIMELESS	1.0	0.216
GINS2	GINS1	1.0	0.838	structurally_consistent (O75419) structurally_consistent (dimer)
MCM6	MCM4	1.0	0.986	structurally_consistent (dimer)
GINS2	GINS3	1.0	0.908
MCM2	MCM6	1.0	0.992	mutually_exclusive (Q9BTE3)
GINS4	GINS1	1.0	0.836
GINS4	GINS3	1.0	0.922
MCM2	MCM4	1.0	0.992
MCM4	MCM7	1.0	0.988	structurally_consistent (dimer)
MCM3	MCMBP	0.999	0.254486486486	mutually_exclusive (Q14566) structurally_consistent (dimer)
MCM3	MCM5	0.999	0.962
MCM4	MCM5	0.999	0.97
MCM6	MCM7	0.999	0.974	mutually_exclusive (Q9BTE3)
MCM2	MCM7	0.999	0.98
MCM3	MCM4	0.999	0.988
MCM3	MCM6	0.999	0.974	mutually_exclusive (Q9BTE3) structurally_consistent (dimer)
MCM4	TIPIN	0.999	0.384
MCM5	MCM7	0.998	0.98
MCMBP	MCM6	0.998	0.304	mixed_interface
MCM2	TIPIN	0.998	0.378
GINS4	TIMELESS	0.998	0.204
MCM3	MCM7	0.998	0.986
MCM2	GINS4	0.997	0.572
MCM2	MCM5	0.997	0.978
MCM6	MCM5	0.997	0.98	structurally_consistent (dimer)
GINS4	TIPIN	0.997	0.09
MCM3	MCM2	0.996	0.986	mutually_exclusive (Q9BTE3)
MCMBP	MCM7	0.996	0.396	mutually_exclusive (P33991) structurally_consistent (dimer)
CLSPN	GINS4	0.996	0.12
TIPIN	GINS3	0.996	0.084
CLSPN	TIMELESS	0.995	0.124
MCM2	TIMELESS	0.995	0.512
GINS3	TIMELESS	0.995	0.158
MCM6	TIMELESS	0.995	0.476
TIPIN	MCM7	0.994	0.402
MCM3	GINS4	0.994	0.256
MCM3	GINS3	0.993	0.646
MCM3	TIPIN	0.992	0.236
MCM6	TIPIN	0.991	0.374
MCM4	TIMELESS	0.991	0.382
MCM6	GINS3	0.991	0.764
SPIN2B	SPIN4	0.99		mutually_exclusive (Q9Y657) structurally_consistent (dimer)
MCM6	GINS4	0.989	0.54
MCM4	GINS3	0.989	0.642
GINS4	MCM7	0.989	0.59
CLSPN	TIPIN	0.988	0.22
MCM7	TIMELESS	0.988	0.464
MCMBP	MCM2	0.987	0.207047619048	structurally_consistent (dimer)
MCMBP	MCM4	0.98	0.436	mutually_exclusive (Q14566) structurally_consistent (dimer)
MCM3	TIMELESS	0.979	0.342
CLSPN	GINS3	0.978	0.154
TIPIN	MCM5	0.974	0.26
MCM4	GINS4	0.969	0.554
MCM5	TIMELESS	0.967	0.502
MCM3	CLSPN	0.965	0.384
GINS2	MCM5	0.963	0.472
GINS3	MCM5	0.957	0.578
GINS4	MCM5	0.953	0.328
GINS2	TIMELESS	0.952	0.092
GINS2	MCM7	0.939	0.47
MCM2	CLSPN	0.936	0.434
MCM6	SPIN2B	0.93
MCM6	CLSPN	0.927	0.504
CLSPN	MCM7	0.925	0.516
MCM2	GINS3	0.92	0.686
SPIN2B	UBR7	0.917		structurally_consistent (dimer)
GINS3	MCM7	0.915	0.516
GINS1	TIMELESS	0.908	0.128
TIPIN	GINS1	0.896	0.104
MCM3	GINS2	0.879	0.302
GINS1	MCM5	0.877	0.594
MCM6	UBR7	0.86	0.104
MCM2	SPIN4	0.858
MCM4	SPIN2B	0.844
MCM3	GINS1	0.841	0.404
GINS1	MCM7	0.835	0.592
MCM6	SPIN4	0.83
MCM2	GINS2	0.828	0.556
MCM4	GINS2	0.825	0.614
MCM2	SPIN2B	0.822
MCM4	UBR7	0.789	0.128
MCM6	GINS2	0.759	0.666
MCM6	GINS1	0.704	0.412
GINS2	TIPIN	0.699	0.098
MCM2	UBR7	0.672	0.092
MCM4	GINS1	0.632	0.736
CLSPN	GINS1	0.568	0.074
UBR7	MCM7	0.532	0.108
GINS2	CLSPN	0.401	0.078
MCM4	CLSPN	0.372	0.576
UBR7	TIMELESS	0.371	0.176
UBR7	GINS3	0.215	0.032
MCM2	GINS1	0.202	0.622
MCM4	SPIN4	0.197
SPIN4	UBR7	0.148		structurally_consistent (Q9BPZ2)
MCMBP	GINS2	0.105	0.078
MCMBP	TIPIN	0.093	0.09
UBR7	TIPIN	0.081	0.158
CLSPN	MCM5	0.064	0.34
UBR7	GINS4	0.051	0.056
MCMBP	GINS1	0.038	0.124
MCMBP	GINS4	0.038	0.166
SPIN2B	MCM7	0.037
MCMBP	TIMELESS	0.024	0.074
UBR7	GINS1	0.023	0.064
MCMBP	CLSPN	0.022	0.118
MCMBP	GINS3	0.022	0.084
SPIN4	MCM7	0.019
MCM3	UBR7	0.01	0.134
MCM3	SPIN2B	0.009
MCMBP	UBR7	0.006	0.092
UBR7	MCM5	0.006	0.2

Related Complexes

Genename	Complexes
UBR7	huMAP3_03836.1 huMAP3_07577.1 huMAP3_09048.1 huMAP3_09859.1 huMAP3_10747.1 huMAP3_12180.1 huMAP3_13086.1
TIMELESS	huMAP3_06136.1 huMAP3_06417.1 huMAP3_07113.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
MCM3	huMAP3_00154.1 huMAP3_06136.1 huMAP3_06417.1 huMAP3_06922.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
GINS1	huMAP3_05447.1 huMAP3_06136.1 huMAP3_06278.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
MCMBP	huMAP3_00154.1 huMAP3_02113.1 huMAP3_05529.1 huMAP3_06061.1 huMAP3_07113.1 huMAP3_08554.1 huMAP3_09860.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
MCM2	huMAP3_00154.1 huMAP3_02113.1 huMAP3_02289.1 huMAP3_05529.1 huMAP3_06061.1 huMAP3_07113.1 huMAP3_07824.1 huMAP3_08554.1 huMAP3_09466.1 huMAP3_09860.1 huMAP3_10747.1 huMAP3_10862.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14306.1 huMAP3_14758.1
MCM5	huMAP3_05529.1 huMAP3_06417.1 huMAP3_06922.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
SPIN2B	huMAP3_00305.1 huMAP3_02306.1 huMAP3_05238.1 huMAP3_06000.1 huMAP3_06370.1 huMAP3_06943.1 huMAP3_07230.1 huMAP3_08714.1 huMAP3_08760.1 huMAP3_09393.1 huMAP3_09544.1 huMAP3_09765.1 huMAP3_10869.1 huMAP3_11058.1 huMAP3_12180.1 huMAP3_13086.1 huMAP3_14120.1 huMAP3_14242.1
MCM6	huMAP3_00154.1 huMAP3_02602.1 huMAP3_05529.1 huMAP3_06061.1 huMAP3_07113.1 huMAP3_08554.1 huMAP3_08848.1 huMAP3_09466.1 huMAP3_09860.1 huMAP3_10862.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14306.1 huMAP3_14758.1
CLSPN	huMAP3_04079.1 huMAP3_04983.1 huMAP3_06136.1 huMAP3_06417.1 huMAP3_06922.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
SPIN4	huMAP3_00305.1 huMAP3_03119.1 huMAP3_03136.1 huMAP3_03308.1 huMAP3_03851.1 huMAP3_06000.1 huMAP3_06370.1 huMAP3_07230.1 huMAP3_08714.1 huMAP3_08760.1 huMAP3_09393.1 huMAP3_09544.1 huMAP3_09765.1 huMAP3_10869.1 huMAP3_11058.1 huMAP3_12180.1 huMAP3_13086.1 huMAP3_14120.1 huMAP3_14242.1
GINS4	huMAP3_04079.1 huMAP3_04983.1 huMAP3_06136.1 huMAP3_06417.1 huMAP3_06922.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
MCM7	huMAP3_05529.1 huMAP3_06061.1 huMAP3_07113.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
GINS3	huMAP3_05447.1 huMAP3_06136.1 huMAP3_06278.1 huMAP3_06417.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
TIPIN	huMAP3_04079.1 huMAP3_06136.1 huMAP3_06417.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
MCM4	huMAP3_00154.1 huMAP3_02602.1 huMAP3_05529.1 huMAP3_06061.1 huMAP3_07113.1 huMAP3_08554.1 huMAP3_08848.1 huMAP3_09466.1 huMAP3_09860.1 huMAP3_10862.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14306.1 huMAP3_14758.1
GINS2	huMAP3_03896.1 huMAP3_05447.1 huMAP3_06136.1 huMAP3_06278.1 huMAP3_06417.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_13708.1 huMAP3_14758.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_12180.1

Complex Portal: CPX-21202