hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_12185.1
Complex Portal: CPX-15810
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta) (Serine/threonine protein kinase PIK3CB) (EC 2.7.11.1) | 5 | UniProt NCBI |
| UBQLNL | Ubiquilin-like protein | 4 | UniProt NCBI |
| PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide 3-kinase alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1) | 5 | UniProt NCBI |
| IRS2 | Insulin receptor substrate 2 (IRS-2) | 5 | UniProt NCBI |
| NYAP2 | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 | 4 | UniProt NCBI |
| PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta) | 5 | UniProt NCBI |
| PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta) | 5 | UniProt NCBI |
| PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK) | 5 | UniProt NCBI |
| PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4582 | 5.23199486267e-16 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Cancer immunotherapy by CTLA4 blockade |
| REAC:R-HSA-8853659 | 6.13748724887e-16 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | RET signaling |
| KEGG:04930 | 1.44411626581e-15 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | Type II diabetes mellitus |
| KEGG:04923 | 2.06940306306e-15 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | Regulation of lipolysis in adipocytes |
| GO:0005943 | 2.17398353113e-15 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | phosphatidylinositol 3-kinase complex, class IA |
| GO:0097651 | 2.17398353113e-15 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | phosphatidylinositol 3-kinase complex, class I |
| KEGG:04213 | 1.13582210128e-14 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | Longevity regulating pathway - multiple species |
| REAC:R-HSA-2219530 | 3.00407347978e-14 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | Constitutive Signaling by Aberrant PI3K in Cancer |
| WP:WP3879 | 3.06774110934e-14 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression |
| REAC:R-HSA-912631 | 3.9851055575e-14 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Regulation of signaling by CBL |
| REAC:R-HSA-912526 | 7.96740344986e-14 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Interleukin receptor SHC signaling |
| REAC:R-HSA-198203 | 1.12866101306e-13 | 0.555555555556 | PIK3R2 PIK3CA PIK3CB PIK3R1 IRS2 | PI3K/AKT activation |
| KEGG:04960 | 1.85705297597e-13 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Aldosterone-regulated sodium reabsorption |
| KEGG:04211 | 2.22286105039e-13 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | Longevity regulating pathway |
| REAC:R-HSA-9027276 | 3.00907593977e-13 | 0.555555555556 | PIK3CD PIK3CA PIK3CB PIK3R1 IRS2 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) |
| KEGG:04973 | 5.0720194186e-13 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Carbohydrate digestion and absorption |
| REAC:R-HSA-6811558 | 5.39673461853e-13 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| REAC:R-HSA-2219528 | 6.55455841067e-13 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | PI3K/AKT Signaling in Cancer |
| WP:WP3937 | 7.58583102697e-13 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Microglia pathogen phagocytosis pathway |
| KEGG:04931 | 8.82576783975e-13 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | Insulin resistance |
| KEGG:04935 | 1.02096838183e-12 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | Growth hormone synthesis, secretion and action |
| REAC:R-HSA-199418 | 1.04190027433e-12 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | Negative regulation of the PI3K/AKT network |
| REAC:R-HSA-451927 | 1.62276991723e-12 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Interleukin-2 family signaling |
| KEGG:04068 | 2.45936161936e-12 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | FoxO signaling pathway |
| KEGG:04152 | 2.45936161936e-12 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | AMPK signaling pathway |
| KEGG:04929 | 2.54066802995e-12 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | GnRH secretion |
| WP:WP4539 | 3.97459024806e-12 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Synaptic signaling pathways associated with autism spectrum disorder |
| WP:WP3915 | 4.72831977792e-12 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | Angiopoietin like protein 8 regulatory pathway |
| REAC:R-HSA-512988 | 4.77522655503e-12 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| KEGG:04910 | 5.36820559928e-12 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | Insulin signaling pathway |
| KEGG:04370 | 5.61170140132e-12 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | VEGF signaling pathway |
| KEGG:05213 | 6.3425430309e-12 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Endometrial cancer |
| KEGG:04664 | 7.1509671991e-12 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Fc epsilon RI signaling pathway |
| KEGG:04932 | 1.08307240887e-11 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | Non-alcoholic fatty liver disease |
| KEGG:05221 | 1.40199812555e-11 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Acute myeloid leukemia |
| REAC:R-HSA-1660499 | 1.56935198351e-11 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Synthesis of PIPs at the plasma membrane |
| KEGG:05206 | 1.69444956336e-11 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | MicroRNAs in cancer |
| WP:WP4396 | 1.76250124831e-11 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | Nonalcoholic fatty liver disease |
| KEGG:04917 | 1.91181420281e-11 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Prolactin signaling pathway |
| KEGG:05218 | 1.91181420281e-11 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Melanoma |
| WP:WP4155 | 2.03852347862e-11 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Endometrial cancer |
| WP:WP4205 | 2.03852347862e-11 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | MET in type 1 papillary renal cell carcinoma |
| WP:WP481 | 2.39334808845e-11 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | Insulin signaling |
| KEGG:04140 | 2.46548456096e-11 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | Autophagy - animal |
| WP:WP5293 | 2.53024844191e-11 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Acute myeloid leukemia |
| KEGG:05211 | 2.56740637956e-11 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Renal cell carcinoma |
| WP:WP4685 | 2.81089082764e-11 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Melanoma |
| KEGG:05230 | 3.10083641807e-11 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Central carbon metabolism in cancer |
| WP:WP1403 | 3.11698305441e-11 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | AMP activated protein kinase signaling |
| KEGG:05214 | 3.40031668352e-11 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Glioma |
| KEGG:04662 | 3.40031668352e-11 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | B cell receptor signaling pathway |
| KEGG:05223 | 3.40031668352e-11 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Non-small cell lung cancer |
| KEGG:04750 | 3.72349856108e-11 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Inflammatory mediator regulation of TRP channels |
| KEGG:01524 | 4.07185716174e-11 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Platinum drug resistance |
| KEGG:05212 | 4.85034501158e-11 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Pancreatic cancer |
| GO:0005942 | 5.48276887252e-11 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | phosphatidylinositol 3-kinase complex |
| WP:WP4255 | 5.59621755013e-11 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Non small cell lung cancer |
| KEGG:01521 | 5.74896973917e-11 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | EGFR tyrosine kinase inhibitor resistance |
| KEGG:05220 | 5.74896973917e-11 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Chronic myeloid leukemia |
| REAC:R-HSA-9006335 | 6.23246168802e-11 | 0.555555555556 | PIK3CD PIK3CA PIK3CB PIK3R1 IRS2 | Signaling by Erythropoietin |
| WP:WP1544 | 6.719963644e-11 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | MicroRNAs in cardiomyocyte hypertrophy |
| KEGG:05100 | 6.78210105863e-11 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Bacterial invasion of epithelial cells |
| KEGG:04012 | 6.78210105863e-11 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | ErbB signaling pathway |
| KEGG:05210 | 7.96535674679e-11 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Colorectal cancer |
| KEGG:05235 | 9.31567233508e-11 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| KEGG:01522 | 1.08513726338e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Endocrine resistance |
| KEGG:04914 | 1.08513726338e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Progesterone-mediated oocyte maturation |
| KEGG:05231 | 1.16948664478e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Choline metabolism in cancer |
| KEGG:04070 | 1.35462228424e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Phosphatidylinositol signaling system |
| KEGG:04625 | 1.35462228424e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | C-type lectin receptor signaling pathway |
| KEGG:05146 | 1.45596149329e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Amoebiasis |
| KEGG:05222 | 1.45596149329e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Small cell lung cancer |
| KEGG:04670 | 1.45596149329e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Leukocyte transendothelial migration |
| WP:WP4806 | 1.55542270855e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | EGFR tyrosine kinase inhibitor resistance |
| KEGG:04933 | 1.56353399253e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | AGE-RAGE signaling pathway in diabetic complications |
| KEGG:04620 | 1.56353399253e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Toll-like receptor signaling pathway |
| KEGG:05142 | 1.67764222254e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Chagas disease |
| KEGG:04725 | 1.79859945803e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Cholinergic synapse |
| WP:WP673 | 1.81541919834e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | ErbB signaling pathway |
| WP:WP4263 | 1.81541919834e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Pancreatic adenocarcinoma pathway |
| KEGG:04666 | 1.92673006117e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Fc gamma R-mediated phagocytosis |
| KEGG:05215 | 1.92673006117e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Prostate cancer |
| WP:WP75 | 2.11062461987e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Toll like receptor signaling pathway |
| KEGG:04915 | 2.20586579611e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Estrogen signaling pathway |
| REAC:R-HSA-1483255 | 2.27345555282e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | PI Metabolism |
| WP:WP4829 | 2.44521169334e-10 | 0.555555555556 | PIK3CA PIK3R3 PIK3CB PIK3R1 PIK3R2 | mBDNF and proBDNF regulation of GABA neurotransmission |
| KEGG:04668 | 2.68714490146e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | TNF signaling pathway |
| WP:WP3844 | 2.93358373077e-10 | 0.555555555556 | PIK3CA PIK3R3 PIK3CB PIK3R1 PIK3R2 | PI3K AKT mTOR signaling pathway and therapeutic opportunities in prostate cancer |
| WP:WP4658 | 3.24601252553e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Small cell lung cancer |
| KEGG:04611 | 3.25280391541e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Platelet activation |
| KEGG:04066 | 3.46204957771e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | HIF-1 signaling pathway |
| KEGG:04722 | 3.6823797837e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Neurotrophin signaling pathway |
| REAC:R-HSA-114604 | 4.31912768671e-10 | 0.555555555556 | PIK3CA PIK3R3 PIK3CB PIK3R1 PIK3R2 | GPVI-mediated activation cascade |
| REAC:R-HSA-109704 | 4.31912768671e-10 | 0.555555555556 | PIK3R2 PIK3CA PIK3CB PIK3R1 IRS2 | PI3K Cascade |
| KEGG:04660 | 4.41458816203e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | T cell receptor signaling pathway |
| KEGG:04071 | 4.41458816203e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Sphingolipid signaling pathway |
| KEGG:04919 | 4.96704186094e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Thyroid hormone signaling pathway |
| KEGG:04926 | 5.90281302576e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Relaxin signaling pathway |
| KEGG:04650 | 6.2455603536e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Natural killer cell mediated cytotoxicity |
| WP:WP710 | 7.06423638489e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | DNA damage response only ATM dependent |
| WP:WP2059 | 7.19812182813e-10 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | Alzheimer 39 s disease and miRNA effects |
| WP:WP5124 | 7.19812182813e-10 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | Alzheimer 39 s disease |
| WP:WP4787 | 7.50442292831e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Osteoblast differentiation and related diseases |
| REAC:R-HSA-112399 | 7.61897575574e-10 | 0.555555555556 | PIK3R2 PIK3CA PIK3CB PIK3R1 IRS2 | IRS-mediated signalling |
| KEGG:04380 | 8.66886542399e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Osteoclast differentiation |
| KEGG:05135 | 8.66886542399e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Yersinia infection |
| KEGG:04072 | 9.14009361523e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Phospholipase D signaling pathway |
| KEGG:05418 | 9.63244640737e-10 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Fluid shear stress and atherosclerosis |
| KEGG:04550 | 1.12438410122e-09 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Signaling pathways regulating pluripotency of stem cells |
| KEGG:04210 | 1.12438410122e-09 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Apoptosis |
| REAC:R-HSA-2428924 | 1.26802952045e-09 | 0.555555555556 | PIK3R2 PIK3CA PIK3CB PIK3R1 IRS2 | IGF1R signaling cascade |
| REAC:R-HSA-2404192 | 1.26802952045e-09 | 0.555555555556 | PIK3R2 PIK3CA PIK3CB PIK3R1 IRS2 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| REAC:R-HSA-2428928 | 1.26802952045e-09 | 0.555555555556 | PIK3R2 PIK3CA PIK3CB PIK3R1 IRS2 | IRS-related events triggered by IGF1R |
| KEGG:05162 | 1.37358391764e-09 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Measles |
| KEGG:05017 | 1.44258458994e-09 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Spinocerebellar ataxia |
| WP:WP4566 | 1.53881385715e-09 | 0.555555555556 | PIK3CA PIK3R3 PIK3CB PIK3R1 PIK3R2 | Translation inhibitors in chronically activated PDGFRA cells |
| KEGG:05224 | 1.58926018983e-09 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Breast cancer |
| WP:WP4217 | 1.64955339151e-09 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Ebola virus infection in host |
| REAC:R-HSA-1257604 | 1.81303445631e-09 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | PIP3 activates AKT signaling |
| KEGG:05160 | 1.9200156679e-09 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Hepatitis C |
| KEGG:04630 | 1.9200156679e-09 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | JAK-STAT signaling pathway |
| KEGG:05226 | 1.9200156679e-09 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Gastric cancer |
| REAC:R-HSA-74751 | 2.01279774624e-09 | 0.555555555556 | PIK3R2 PIK3CA PIK3CB PIK3R1 IRS2 | Insulin receptor signalling cascade |
| WP:WP3929 | 2.1347204781e-09 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Chemokine signaling pathway |
| WP:WP4630 | 2.35943603795e-09 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Measles virus infection |
| KEGG:04062 | 2.75481259175e-09 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Chemokine signaling pathway |
| KEGG:04218 | 2.87765198904e-09 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Cellular senescence |
| WP:WP51 | 3.00873475938e-09 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Regulation of actin cytoskeleton |
| WP:WP395 | 3.14547231942e-09 | 0.555555555556 | PIK3R2 PIK3CA IRS2 PIK3R1 PIK3CD | IL 4 signaling pathway |
| REAC:R-HSA-2730905 | 3.29426179613e-09 | 0.444444444444 | PIK3CA PIK3CB PIK3R1 PIK3R2 | Role of LAT2/NTAL/LAB on calcium mobilization |
| REAC:R-HSA-9673770 | 3.29426179613e-09 | 0.444444444444 | PIK3CA PIK3CB PIK3R1 PIK3R2 | Signaling by PDGFRA extracellular domain mutants |
| REAC:R-HSA-9673767 | 3.29426179613e-09 | 0.444444444444 | PIK3CA PIK3CB PIK3R1 PIK3R2 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants |
| GO:0046854 | 3.31133268521e-09 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | phosphatidylinositol phosphate biosynthetic process |
| KEGG:05164 | 3.41557464501e-09 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Influenza A |
| WP:WP4239 | 3.62950083875e-09 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Epithelial to mesenchymal transition in colorectal cancer |
| KEGG:04150 | 4.03464362548e-09 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | mTOR signaling pathway |
| KEGG:05161 | 4.03464362548e-09 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Hepatitis B |
| KEGG:04613 | 4.20318345704e-09 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Neutrophil extracellular trap formation |
| WP:WP4666 | 4.55190842399e-09 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Hepatitis B infection |
| REAC:R-HSA-9006925 | 4.92624860503e-09 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | Intracellular signaling by second messengers |
| KEGG:04360 | 5.13634872351e-09 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Axon guidance |
| KEGG:04024 | 6.00151760256e-09 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | cAMP signaling pathway |
| KEGG:05010 | 6.06689477461e-09 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | Alzheimer disease |
| KEGG:05225 | 6.23576398148e-09 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Hepatocellular carcinoma |
| WP:WP4223 | 6.98754475873e-09 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Ras signaling |
| KEGG:05207 | 7.2502502829e-09 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Chemical carcinogenesis - receptor activation |
| KEGG:04015 | 8.09810271239e-09 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Rap1 signaling pathway |
| KEGG:05167 | 8.70790839343e-09 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Kaposi sarcoma-associated herpesvirus infection |
| KEGG:04510 | 1.04014617635e-08 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Focal adhesion |
| KEGG:05169 | 1.32253757208e-08 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Epstein-Barr virus infection |
| KEGG:05417 | 1.32253757208e-08 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Lipid and atherosclerosis |
| KEGG:05415 | 1.41401120552e-08 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Diabetic cardiomyopathy |
| KEGG:05205 | 1.41401120552e-08 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Proteoglycans in cancer |
| KEGG:04014 | 1.51068550994e-08 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Ras signaling pathway |
| KEGG:05203 | 1.61279345025e-08 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Viral carcinogenesis |
| WP:WP306 | 1.87719811753e-08 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Focal adhesion |
| KEGG:05163 | 1.95416489488e-08 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Human cytomegalovirus infection |
| WP:WP2037 | 1.97134150672e-08 | 0.555555555556 | PIK3R2 PIK3CA PIK3CB PIK3R1 IRS2 | Prolactin signaling pathway |
| KEGG:05170 | 2.0165066209e-08 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Human immunodeficiency virus 1 infection |
| REAC:R-HSA-210993 | 2.13833966452e-08 | 0.444444444444 | PIK3CA PIK3CB PIK3R1 PIK3R2 | Tie2 Signaling |
| KEGG:04810 | 2.14615859599e-08 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Regulation of actin cytoskeleton |
| KEGG:05166 | 2.3535816974e-08 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Human T-cell leukemia virus 1 infection |
| KEGG:05171 | 2.65583380213e-08 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Coronavirus disease - COVID-19 |
| KEGG:05208 | 2.65583380213e-08 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Chemical carcinogenesis - reactive oxygen species |
| REAC:R-HSA-74752 | 3.43444959498e-08 | 0.555555555556 | PIK3R2 PIK3CA PIK3CB PIK3R1 IRS2 | Signaling by Insulin receptor |
| REAC:R-HSA-9669938 | 3.72634490188e-08 | 0.444444444444 | PIK3CA PIK3R3 PIK3R1 PIK3R2 | Signaling by KIT in disease |
| REAC:R-HSA-9670439 | 3.72634490188e-08 | 0.444444444444 | PIK3CA PIK3R3 PIK3R1 PIK3R2 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants |
| REAC:R-HSA-9671555 | 3.72634490188e-08 | 0.444444444444 | PIK3CA PIK3CB PIK3R1 PIK3R2 | Signaling by PDGFR in disease |
| GO:0052742 | 3.80200340498e-08 | 0.555555555556 | PIK3CA PIK3R3 PIK3CB PIK3R1 PIK3CD | phosphatidylinositol kinase activity |
| WP:WP2261 | 4.02378703463e-08 | 0.555555555556 | PIK3R2 PIK3CA PIK3CB PIK3R1 PIK3CD | Glioblastoma signaling pathways |
| REAC:R-HSA-5663202 | 5.24526758993e-08 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | Diseases of signal transduction by growth factor receptors and second messengers |
| KEGG:05131 | 5.36942521978e-08 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Shigellosis |
| REAC:R-HSA-1483257 | 5.41042940288e-08 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Phospholipid metabolism |
| REAC:R-HSA-389357 | 7.57954108849e-08 | 0.444444444444 | PIK3CA PIK3R3 PIK3R1 PIK3R2 | CD28 dependent PI3K/Akt signaling |
| GO:0043491 | 8.19051020603e-08 | 0.777777777778 | PIK3CD PIK3CA PIK3R2 PIK3R1 NYAP2 PIK3CB PIK3R3 | phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| REAC:R-HSA-449147 | 8.28430472922e-08 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | Signaling by Interleukins |
| KEGG:05020 | 8.50191751365e-08 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Prion disease |
| REAC:R-HSA-2029485 | 9.3603973851e-08 | 0.444444444444 | PIK3CA PIK3CB PIK3R1 PIK3R2 | Role of phospholipids in phagocytosis |
| REAC:R-HSA-373753 | 9.3603973851e-08 | 0.444444444444 | PIK3CA PIK3CB PIK3R1 PIK3R2 | Nephrin family interactions |
| REAC:R-HSA-201556 | 1.14373512426e-07 | 0.444444444444 | PIK3CA PIK3CB PIK3R1 PIK3R2 | Signaling by ALK |
| REAC:R-HSA-2424491 | 1.14373512426e-07 | 0.444444444444 | PIK3CA PIK3CB PIK3R1 PIK3R2 | DAP12 signaling |
| WP:WP3932 | 1.65097397123e-07 | 0.666666666667 | PIK3CD PIK3CA PIK3R2 PIK3R1 PIK3CB IRS2 | Focal adhesion PI3K Akt mTOR signaling pathway |
| KEGG:04151 | 2.15477246223e-07 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | PI3K-Akt signaling pathway |
| WP:WP5420 | 2.24487840352e-07 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | ADHD and autism ASD linked metabolic pathways and SNP |
| GO:0016303 | 2.31823352537e-07 | 0.444444444444 | PIK3CA PIK3R3 PIK3CB PIK3CD | 1-phosphatidylinositol-3-kinase activity |
| REAC:R-HSA-186763 | 2.33494282896e-07 | 0.444444444444 | PIK3CA PIK3CB PIK3R1 PIK3R2 | Downstream signal transduction |
| WP:WP524 | 2.45606157072e-07 | 0.444444444444 | PIK3R2 PIK3CA PIK3CB PIK3CD | G13 signaling pathway |
| KEGG:05165 | 2.54270193537e-07 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Human papillomavirus infection |
| WP:WP4564 | 2.78277339914e-07 | 0.444444444444 | PIK3CA PIK3R3 PIK3CB PIK3CD | Neural crest cell migration during development |
| WP:WP4172 | 2.81399696502e-07 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | PI3K Akt signaling pathway |
| REAC:R-HSA-422475 | 3.27550528028e-07 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | Axon guidance |
| REAC:R-HSA-187037 | 3.39312532068e-07 | 0.555555555556 | PIK3R2 PIK3CA PIK3CB PIK3R1 IRS2 | Signaling by NTRK1 (TRKA) |
| WP:WP4565 | 3.53263332843e-07 | 0.444444444444 | PIK3CA PIK3R3 PIK3CB PIK3CD | Neural crest cell migration in cancer |
| REAC:R-HSA-389356 | 3.70646453728e-07 | 0.444444444444 | PIK3CA PIK3R3 PIK3R1 PIK3R2 | CD28 co-stimulation |
| REAC:R-HSA-2172127 | 3.70646453728e-07 | 0.444444444444 | PIK3CA PIK3CB PIK3R1 PIK3R2 | DAP12 interactions |
| REAC:R-HSA-9675108 | 4.23118782221e-07 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | Nervous system development |
| GO:0001727 | 4.24700324456e-07 | 0.555555555556 | PIK3CA PIK3R3 PIK3CB PIK3R1 PIK3CD | lipid kinase activity |
| GO:0006661 | 5.514531492e-07 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | phosphatidylinositol biosynthetic process |
| REAC:R-HSA-1266695 | 5.60712805559e-07 | 0.444444444444 | PIK3R2 IRS2 PIK3R1 PIK3R3 | Interleukin-7 signaling |
| WP:WP4262 | 6.46199131008e-07 | 0.555555555556 | PIK3CA PIK3R3 PIK3CD PIK3R1 PIK3R2 | Breast cancer pathway |
| REAC:R-HSA-166520 | 7.69920750107e-07 | 0.555555555556 | PIK3R2 PIK3CA PIK3CB PIK3R1 IRS2 | Signaling by NTRKs |
| REAC:R-HSA-1433557 | 9.17480125108e-07 | 0.444444444444 | PIK3CA PIK3R3 PIK3R1 PIK3R2 | Signaling by SCF-KIT |
| KEGG:05168 | 9.59358896541e-07 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Herpes simplex virus 1 infection |
| WP:WP5191 | 1.2353479002e-06 | 0.333333333333 | PIK3CA PIK3CB PIK3CD | Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution |
| GO:0046488 | 1.42671615945e-06 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | phosphatidylinositol metabolic process |
| WP:WP585 | 1.49253941088e-06 | 0.444444444444 | PIK3R2 IRS2 PIK3R1 PIK3CD | Interferon type I signaling pathways |
| REAC:R-HSA-1280215 | 1.67272214645e-06 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | Cytokine Signaling in Immune system |
| GO:0019898 | 2.97195943126e-06 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | extrinsic component of membrane |
| REAC:R-HSA-186797 | 3.0207398275e-06 | 0.444444444444 | PIK3CA PIK3CB PIK3R1 PIK3R2 | Signaling by PDGF |
| KEGG:05200 | 3.06894136919e-06 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Pathways in cancer |
| WP:WP4674 | 5.44771093324e-06 | 0.444444444444 | PIK3CA PIK3CB PIK3R1 PIK3R2 | Head and neck squamous cell carcinoma |
| REAC:R-HSA-388841 | 6.11717158058e-06 | 0.444444444444 | PIK3CA PIK3R3 PIK3R1 PIK3R2 | Costimulation by the CD28 family |
| GO:0046474 | 8.30602098472e-06 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | glycerophospholipid biosynthetic process |
| REAC:R-HSA-9009391 | 8.62700529853e-06 | 0.444444444444 | PIK3CA PIK3R3 PIK3R1 PIK3R2 | Extra-nuclear estrogen signaling |
| REAC:R-HSA-9006934 | 1.18963943652e-05 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB IRS2 | Signaling by Receptor Tyrosine Kinases |
| WP:WP4483 | 1.67087068217e-05 | 0.333333333333 | PIK3CA PIK3CB PIK3CD | Relationship between inflammation COX 2 and EGFR |
| REAC:R-HSA-1266738 | 1.74708859428e-05 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | Developmental Biology |
| REAC:R-HSA-5673001 | 1.78648945088e-05 | 0.555555555556 | PIK3R2 PIK3CA PIK3CB PIK3R1 IRS2 | RAF/MAP kinase cascade |
| GO:0008654 | 1.81410356673e-05 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | phospholipid biosynthetic process |
| REAC:R-HSA-5684996 | 1.96056621819e-05 | 0.555555555556 | PIK3R2 PIK3CA PIK3CB PIK3R1 IRS2 | MAPK1/MAPK3 signaling |
| REAC:R-HSA-76002 | 1.96056621819e-05 | 0.555555555556 | PIK3CA PIK3R3 PIK3CB PIK3R1 PIK3R2 | Platelet activation, signaling and aggregation |
| REAC:R-HSA-2029480 | 2.19627733949e-05 | 0.444444444444 | PIK3CA PIK3CB PIK3R1 PIK3R2 | Fcgamma receptor (FCGR) dependent phagocytosis |
| GO:0045017 | 2.25755784774e-05 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | glycerolipid biosynthetic process |
| GO:0007169 | 2.55246115587e-05 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | transmembrane receptor protein tyrosine kinase signaling pathway |
| GO:0008286 | 2.68109964568e-05 | 0.555555555556 | PIK3CA PIK3R3 IRS2 PIK3R1 PIK3R2 | insulin receptor signaling pathway |
| CORUM:3133 | 2.73623797451e-05 | 0.222222222222 | PIK3CA PIK3R1 | Phosphatidylinositol 3-kinase (PIK3CA, PIK3R1) |
| WP:WP4659 | 2.81297285008e-05 | 0.444444444444 | PIK3CA PIK3R3 PIK3R1 PIK3R2 | Gastrin signaling pathway |
| REAC:R-HSA-9013404 | 2.82551309181e-05 | 0.444444444444 | PIK3CA PIK3R3 PIK3R1 PIK3R2 | RAC2 GTPase cycle |
| REAC:R-HSA-4420097 | 3.41876218612e-05 | 0.444444444444 | PIK3CA PIK3CB PIK3R1 PIK3R2 | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-202424 | 3.74804354083e-05 | 0.444444444444 | PIK3CA PIK3CB PIK3R1 PIK3R2 | Downstream TCR signaling |
| REAC:R-HSA-5683057 | 3.89471992676e-05 | 0.555555555556 | PIK3R2 PIK3CA PIK3CB PIK3R1 IRS2 | MAPK family signaling cascades |
| WP:WP2533 | 4.27786265801e-05 | 0.333333333333 | PIK3CA PIK3CB PIK3CD | Glycerophospholipid biosynthetic pathway |
| WP:WP4481 | 4.78972943695e-05 | 0.333333333333 | PIK3CA PIK3CB PIK3CD | Resistin as a regulator of inflammation |
| REAC:R-HSA-194138 | 4.87888020581e-05 | 0.444444444444 | PIK3CA PIK3CB PIK3R1 PIK3R2 | Signaling by VEGF |
| REAC:R-HSA-202733 | 6.50007996784e-05 | 0.444444444444 | PIK3CA PIK3CB PIK3R1 PIK3R2 | Cell surface interactions at the vascular wall |
| GO:0006650 | 6.54258612435e-05 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | glycerophospholipid metabolic process |
| REAC:R-HSA-1500931 | 6.76084975777e-05 | 0.444444444444 | PIK3CA PIK3CB PIK3R1 PIK3R2 | Cell-Cell communication |
| WP:WP4871 | 7.24291195209e-05 | 0.333333333333 | PIK3CA PIK3CB PIK3CD | Kisspeptin kisspeptin receptor system in the ovary |
| WP:WP244 | 7.24291195209e-05 | 0.333333333333 | PIK3R2 IRS2 PIK3R1 | Alpha 6 beta 4 signaling pathway |
| REAC:R-HSA-202403 | 7.59014156519e-05 | 0.444444444444 | PIK3CA PIK3CB PIK3R1 PIK3R2 | TCR signaling |
| GO:0035005 | 8.06911104389e-05 | 0.333333333333 | PIK3CA PIK3CB PIK3CD | 1-phosphatidylinositol-4-phosphate 3-kinase activity |
| REAC:R-HSA-2454202 | 9.13803206472e-05 | 0.444444444444 | PIK3CA PIK3CB PIK3R1 PIK3R2 | Fc epsilon receptor (FCERI) signaling |
| REAC:R-HSA-556833 | 9.40411082062e-05 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Metabolism of lipids |
| REAC:R-HSA-9680350 | 0.000124396764524 | 0.333333333333 | PIK3CA PIK3CB PIK3R1 | Signaling by CSF1 (M-CSF) in myeloid cells |
| REAC:R-HSA-1280218 | 0.000152242058159 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Adaptive Immune System |
| WP:WP5411 | 0.000167122221162 | 0.333333333333 | PIK3CA PIK3CB PIK3CD | Phosphatidyl inositol phosphate pathway |
| WP:WP286 | 0.000167122221162 | 0.333333333333 | PIK3R2 PIK3CD PIK3R1 | IL 3 signaling pathway |
| WP:WP4971 | 0.000167122221162 | 0.333333333333 | PIK3CA PIK3CB PIK3CD | Phosphoinositides metabolism |
| GO:0061695 | 0.000172106100962 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | transferase complex, transferring phosphorus-containing groups |
| REAC:R-HSA-416476 | 0.000177791163859 | 0.444444444444 | PIK3CA PIK3R3 PIK3R1 PIK3R2 | G alpha (q) signalling events |
| GO:0006644 | 0.000217618400227 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | phospholipid metabolic process |
| GO:0046486 | 0.000236465319712 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | glycerolipid metabolic process |
| HP:0030381 | 0.000306458653145 | 0.222222222222 | PIK3CD PIK3R1 | Increased proportion of transitional B cells |
| HP:0030379 | 0.000306458653145 | 0.222222222222 | PIK3CD PIK3R1 | Abnormal proportion of transitional B cells |
| GO:0032869 | 0.00034088274185 | 0.555555555556 | PIK3CA PIK3R3 IRS2 PIK3R1 PIK3R2 | cellular response to insulin stimulus |
| KEGG:00562 | 0.000349846288075 | 0.333333333333 | PIK3CA PIK3CB PIK3CD | Inositol phosphate metabolism |
| REAC:R-HSA-9013149 | 0.000376424321897 | 0.444444444444 | PIK3CA PIK3R3 PIK3R1 PIK3R2 | RAC1 GTPase cycle |
| WP:WP2032 | 0.000380392295535 | 0.333333333333 | PIK3CA PIK3R1 PIK3R2 | Thyroid stimulating hormone TSH signaling pathway |
| GO:0001775 | 0.000461835613104 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | cell activation |
| GO:0032868 | 0.000492661158189 | 0.555555555556 | PIK3CA PIK3R3 IRS2 PIK3R1 PIK3R2 | response to insulin |
| GO:0007167 | 0.000493150506978 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | enzyme-linked receptor protein signaling pathway |
| GO:0042113 | 0.000510393887561 | 0.555555555556 | PIK3R2 PIK3R3 IRS2 PIK3R1 PIK3CD | B cell activation |
| REAC:R-HSA-8939211 | 0.000706222378001 | 0.444444444444 | PIK3CA PIK3R3 PIK3R1 PIK3R2 | ESR-mediated signaling |
| REAC:R-HSA-1643685 | 0.00078253559574 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | Disease |
| REAC:R-HSA-8851907 | 0.000798060792831 | 0.222222222222 | PIK3CA PIK3R1 | MET activates PI3K/AKT signaling |
| REAC:R-HSA-9028335 | 0.000798060792831 | 0.222222222222 | PIK3CA PIK3R1 | Activated NTRK2 signals through PI3K |
| HP:0011956 | 0.000919082356402 | 0.222222222222 | PIK3CD PIK3R1 | Intestinal lymphoid nodular hyperplasia |
| GO:0036092 | 0.000966803032193 | 0.333333333333 | PIK3CA PIK3CB PIK3CD | phosphatidylinositol-3-phosphate biosynthetic process |
| GO:0044255 | 0.00107652961474 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | cellular lipid metabolic process |
| REAC:R-HSA-9603381 | 0.0011967088847 | 0.222222222222 | PIK3CA PIK3R1 | Activated NTRK3 signals through PI3K |
| GO:0071375 | 0.00149156373472 | 0.555555555556 | PIK3CA PIK3R3 IRS2 PIK3R1 PIK3R2 | cellular response to peptide hormone stimulus |
| REAC:R-HSA-109582 | 0.0015546138994 | 0.555555555556 | PIK3CA PIK3R3 PIK3CB PIK3R1 PIK3R2 | Hemostasis |
| REAC:R-HSA-1250342 | 0.00167485737707 | 0.222222222222 | PIK3CA PIK3R1 | PI3K events in ERBB4 signaling |
| REAC:R-HSA-168256 | 0.00186369688073 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | Immune System |
| REAC:R-HSA-9006931 | 0.0022241973184 | 0.444444444444 | PIK3CA PIK3R3 PIK3R1 PIK3R2 | Signaling by Nuclear Receptors |
| REAC:R-HSA-5655291 | 0.00223242997382 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by FGFR4 in disease |
| GO:0090407 | 0.00247572258938 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | organophosphate biosynthetic process |
| WP:WP22 | 0.00278824374686 | 0.222222222222 | PIK3R2 PIK3R1 | IL 9 signaling pathway |
| GO:0046649 | 0.00287666681264 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 IRS2 PIK3CD PIK3R1 | lymphocyte activation |
| GO:0046935 | 0.00292902387419 | 0.333333333333 | PIK3R2 PIK3R3 PIK3R1 | 1-phosphatidylinositol-3-kinase regulator activity |
| GO:0043434 | 0.00334738121191 | 0.555555555556 | PIK3CA PIK3R3 IRS2 PIK3R1 PIK3R2 | response to peptide hormone |
| REAC:R-HSA-1963642 | 0.00358554253109 | 0.222222222222 | PIK3CA PIK3R1 | PI3K events in ERBB2 signaling |
| REAC:R-HSA-5654710 | 0.00358554253109 | 0.222222222222 | PIK3CA PIK3R1 | PI-3K cascade:FGFR3 |
| GO:1901653 | 0.00359584925391 | 0.555555555556 | PIK3CA PIK3R3 IRS2 PIK3R1 PIK3R2 | cellular response to peptide |
| GO:0071495 | 0.00362705189953 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | cellular response to endogenous stimulus |
| WP:WP3935 | 0.00367445660497 | 0.222222222222 | IRS2 PIK3R3 | Leptin insulin signaling overlap |
| WP:WP205 | 0.00416305404355 | 0.222222222222 | PIK3R2 PIK3R1 | IL 7 signaling pathway |
| WP:WP2380 | 0.00429661916894 | 0.333333333333 | PIK3R2 IRS2 PIK3R1 | Brain derived neurotrophic factor BDNF signaling pathway |
| REAC:R-HSA-5654689 | 0.00438093013445 | 0.222222222222 | PIK3CA PIK3R1 | PI-3K cascade:FGFR1 |
| HP:0031693 | 0.00459101044859 | 0.222222222222 | PIK3CD PIK3R1 | Severe Epstein Barr virus infection |
| GO:0006629 | 0.00490436610904 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | lipid metabolic process |
| REAC:R-HSA-5637812 | 0.00525543712779 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by EGFRvIII in Cancer |
| REAC:R-HSA-5637810 | 0.00525543712779 | 0.222222222222 | PIK3CA PIK3R1 | Constitutive Signaling by EGFRvIII |
| REAC:R-HSA-5654720 | 0.00525543712779 | 0.222222222222 | PIK3CA PIK3R1 | PI-3K cascade:FGFR4 |
| REAC:R-HSA-5654695 | 0.00525543712779 | 0.222222222222 | PIK3CA PIK3R1 | PI-3K cascade:FGFR2 |
| GO:0030183 | 0.00567607484951 | 0.444444444444 | PIK3R2 PIK3CD PIK3R1 PIK3R3 | B cell differentiation |
| REAC:R-HSA-9034015 | 0.00620898744994 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by NTRK3 (TRKC) |
| REAC:R-HSA-9665348 | 0.00620898744994 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by ERBB2 ECD mutants |
| REAC:R-HSA-9703648 | 0.00620898744994 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by FLT3 ITD and TKD mutants |
| REAC:R-HSA-162582 | 0.0063866282108 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | Signal Transduction |
| WP:WP5181 | 0.00642003616322 | 0.222222222222 | IRS2 PIK3R1 | Roles of ceramides in development of insulin resistance |
| GO:0009719 | 0.00654669750354 | 0.777777777778 | PIK3CD PIK3R1 PIK3CA PIK3R2 IRS2 PIK3CB PIK3R3 | response to endogenous stimulus |
| GO:0008610 | 0.00673624890584 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | lipid biosynthetic process |
| REAC:R-HSA-5654708 | 0.00724150508664 | 0.222222222222 | PIK3CA PIK3R1 | Downstream signaling of activated FGFR3 |
| REAC:R-HSA-180292 | 0.00724150508664 | 0.222222222222 | PIK3CA PIK3R1 | GAB1 signalosome |
| REAC:R-HSA-5655332 | 0.00724150508664 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by FGFR3 in disease |
| GO:1901652 | 0.0088969701328 | 0.555555555556 | PIK3CA PIK3R3 IRS2 PIK3R1 PIK3R2 | response to peptide |
| GO:0045321 | 0.00945609870697 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 IRS2 PIK3CD PIK3R1 | leukocyte activation |
| REAC:R-HSA-5654687 | 0.00954313848115 | 0.222222222222 | PIK3CA PIK3R1 | Downstream signaling of activated FGFR1 |
| REAC:R-HSA-5654696 | 0.00954313848115 | 0.222222222222 | PIK3CA PIK3R1 | Downstream signaling of activated FGFR2 |
| REAC:R-HSA-5654716 | 0.00954313848115 | 0.222222222222 | PIK3CA PIK3R1 | Downstream signaling of activated FGFR4 |
| REAC:R-HSA-1839117 | 0.00954313848115 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by cytosolic FGFR1 fusion mutants |
| REAC:R-HSA-5637815 | 0.00954313848115 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by Ligand-Responsive EGFR Variants in Cancer |
| REAC:R-HSA-9703465 | 0.00954313848115 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by FLT3 fusion proteins |
| REAC:R-HSA-1236382 | 0.00954313848115 | 0.222222222222 | PIK3CA PIK3R1 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants |
| WP:WP3972 | 0.00991991165725 | 0.222222222222 | PIK3CA PIK3R1 | PDGFR beta pathway |
| REAC:R-HSA-388396 | 0.0105696022498 | 0.444444444444 | PIK3CA PIK3R3 PIK3R1 PIK3R2 | GPCR downstream signalling |
| REAC:R-HSA-9006115 | 0.0121597301349 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by NTRK2 (TRKB) |
| REAC:R-HSA-9664565 | 0.0121597301349 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by ERBB2 KD Mutants |
| REAC:R-HSA-1227990 | 0.0135859457713 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by ERBB2 in Cancer |
| HP:0011110 | 0.0137554449829 | 0.222222222222 | PIK3CD PIK3R1 | Recurrent tonsillitis |
| HP:0025352 | 0.0137554449829 | 0.222222222222 | PIK3CA PIK3R2 | Typically de novo |
| HP:0031692 | 0.0137554449829 | 0.222222222222 | PIK3CD PIK3R1 | Severe cytomegalovirus infection |
| HP:0200117 | 0.0137554449829 | 0.222222222222 | PIK3CD PIK3R1 | Recurrent upper and lower respiratory tract infections |
| REAC:R-HSA-9012999 | 0.0139509103367 | 0.444444444444 | PIK3CA PIK3R3 PIK3R1 PIK3R2 | RHO GTPase cycle |
| KEGG:05132 | 0.0140921621497 | 0.333333333333 | PIK3CA PIK3CB PIK3CD | Salmonella infection |
| WP:WP127 | 0.0141704493256 | 0.222222222222 | PIK3R2 PIK3R1 | IL 5 signaling pathway |
| REAC:R-HSA-1643713 | 0.0166738379974 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by EGFR in Cancer |
| REAC:R-HSA-372790 | 0.0175710593503 | 0.444444444444 | PIK3CA PIK3R3 PIK3R1 PIK3R2 | Signaling by GPCR |
| WP:WP4558 | 0.0181089215014 | 0.222222222222 | PIK3CA PIK3R1 | Overview of interferons mediated signaling pathway |
| WP:WP2828 | 0.0181089215014 | 0.222222222222 | PIK3R2 PIK3R1 | Bladder cancer |
| REAC:R-HSA-983695 | 0.0183353632609 | 0.222222222222 | PIK3CD PIK3R1 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
| WP:WP2332 | 0.0213754193269 | 0.222222222222 | PIK3R2 PIK3R1 | Interleukin 11 signaling pathway |
| REAC:R-HSA-9682385 | 0.0218931941247 | 0.222222222222 | PIK3CA PIK3R1 | FLT3 signaling in disease |
| REAC:R-HSA-1839124 | 0.0218931941247 | 0.222222222222 | PIK3CA PIK3R1 | FGFR1 mutant receptor activation |
| WP:WP364 | 0.0225236492456 | 0.222222222222 | PIK3R2 PIK3R1 | IL6 signaling pathway |
| HP:0032170 | 0.0238199336716 | 0.222222222222 | PIK3CD PIK3R1 | Severe varicella zoster infection |
| GO:0042110 | 0.0256244466091 | 0.555555555556 | PIK3CA PIK3R3 PIK3CD PIK3R1 PIK3R2 | T cell activation |
| WP:WP61 | 0.0287089830042 | 0.222222222222 | PIK3R2 PIK3R1 | Notch signaling pathway |
| REAC:R-HSA-5654741 | 0.0299458635385 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by FGFR3 |
| WP:WP2018 | 0.0313898659069 | 0.222222222222 | PIK3R2 PIK3R1 | RANKL RANK signaling pathway |
| REAC:R-HSA-5655302 | 0.032153801025 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by FGFR1 in disease |
| REAC:R-HSA-5654743 | 0.032153801025 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by FGFR4 |
| WP:WP195 | 0.0341885469367 | 0.222222222222 | PIK3R2 PIK3R1 | IL 1 signaling pathway |
| GO:0071417 | 0.0353532754544 | 0.555555555556 | PIK3CA PIK3R3 IRS2 PIK3R1 PIK3R2 | cellular response to organonitrogen compound |
| HP:0002007 | 0.0363911312067 | 0.444444444444 | PIK3CA PIK3CD PIK3R1 PIK3R2 | Frontal bossing |
| REAC:R-HSA-5655253 | 0.0368028731299 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by FGFR2 in disease |
| HP:0011218 | 0.037603767825 | 0.444444444444 | PIK3CA PIK3CD PIK3R1 PIK3R2 | Abnormal shape of the frontal region |
| HP:0430000 | 0.0380145177371 | 0.444444444444 | PIK3CA PIK3CD PIK3R1 PIK3R2 | Abnormal frontal bone morphology |
| GO:0141124 | 0.0384238217679 | 0.777777777778 | PIK3CD PIK3CA PIK3R2 PIK3R1 NYAP2 PIK3CB PIK3R3 | intracellular signaling cassette |
| WP:WP304 | 0.0386069386725 | 0.222222222222 | PIK3R2 PIK3R1 | Kit receptor signaling pathway |
| REAC:R-HSA-5654736 | 0.0392438573551 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by FGFR1 |
| REAC:R-HSA-9607240 | 0.0392438573551 | 0.222222222222 | PIK3CA PIK3R1 | FLT3 Signaling |
| GO:0001784 | 0.0396911574974 | 0.333333333333 | PIK3R2 PIK3R3 PIK3R1 | phosphotyrosine residue binding |
| WP:WP5072 | 0.0416991128923 | 0.222222222222 | PIK3R2 PIK3R1 | Modulators of TCR signaling and T cell activation |
| GO:0032870 | 0.0445680276436 | 0.555555555556 | PIK3CA PIK3R3 IRS2 PIK3R1 PIK3R2 | cellular response to hormone stimulus |
| REAC:R-HSA-1430728 | 0.0452440709483 | 0.666666666667 | PIK3R3 PIK3CA PIK3R2 PIK3R1 PIK3CB PIK3CD | Metabolism |
| CORUM:7361 | 0.0499842271994 | 0.111111111111 | PIK3R1 | ARAF-PIK3R1 complex |
| CORUM:2574 | 0.0499842271994 | 0.111111111111 | PIK3R1 | CD19-VAV1-PIK3R1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PIK3CA | PIK3R3 | 1.0 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | ||
| PIK3CB | PIK3R1 | 0.999 | 0.23 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () fraction | |
| PIK3CB | PIK3R3 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| PIK3CA | PIK3R1 | 0.998 | 0.164 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| PIK3CA | PIK3R2 | 0.998 | 0.295459408904 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| PIK3CD | PIK3R3 | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PIK3CD | PIK3R1 | 0.997 | 0.118 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| PIK3CB | PIK3CA | 0.996 | 0.21 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PIK3R2 | PIK3R1 | 0.995 | 0.31 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM | |
| PIK3R2 | PIK3R3 | 0.994 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | |
| IRS2 | PIK3R1 | 0.993 | 0.202 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| PIK3CB | PIK3R2 | 0.992 | 0.350883495146 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| IRS2 | PIK3CD | 0.979 | 0.128 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PIK3R3 | PIK3R1 | 0.979 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | ||
| IRS2 | PIK3CB | 0.954 | 0.238 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PIK3CB | UBQLNL | 0.916 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| PIK3CA | PIK3CD | 0.869 | 0.196 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| IRS2 | PIK3R3 | 0.868 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| IRS2 | PIK3CA | 0.842 | 0.212 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PIK3CB | PIK3CD | 0.838 | 0.166 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| NYAP2 | PIK3R1 | 0.8 | hein_WMM hein () | ||
| NYAP2 | PIK3CD | 0.248 | hein_WMM WMM_only | ||
| NYAP2 | PIK3CB | 0.248 | hein_WMM WMM_only | ||
| NYAP2 | IRS2 | 0.232 | hein_WMM WMM_only | ||
| NYAP2 | PIK3CA | 0.192 | hein_WMM WMM_only | ||
| PIK3CD | PIK3R2 | 0.141 | 0.13 |
mutually_exclusive (Q92569)
|
bioplex_WMM bioplex3_WMM WMM_only |
| PIK3R1 | UBQLNL | 0.065 | bioplex3_WMM WMM_only | ||
| PIK3R2 | UBQLNL | 0.065 | bioplex3_WMM WMM_only | ||
| PIK3R3 | UBQLNL | 0.064 | bioplex3_WMM WMM_only | ||
| IRS2 | PIK3R2 | 0.041 | 0.342519858782 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes